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Enhancement of pain inhibition by working memory with anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex.
J Physiol Sci 2018; 68(6):825-836JP

Abstract

The aim of this study was to examine whether transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) enhances pain inhibition by improving working memory (WM). Forty healthy volunteers participated in two tDCS sessions. Pain was evoked by electrical stimulation at the ankle. Participants performed an n-back task (0-back and 2-back). The experimental protocol comprised five counterbalanced conditions (0-back, 2-back, pain, 0-back with pain and 2-back with pain) that were performed twice (pre-tDCS baseline and during tDCS). Compared with the pre-tDCS baseline values, anodal tDCS decreased response times for the 2-back condition (p < 0.01) but not for the 0-back condition (p > 0.5). Anodal tDCS also decreased pain ratings marginally in the 2-back with pain condition, but not the 0-back with pain condition (p = 0.052 and p > 0.2, respectively). No effect was produced by sham tDCS for any condition (p > 0.2). These results indicate that tDCS of the left DLPFC may enhance pain inhibition by improving WM.

Authors+Show Affiliations

Department of Chiropractic, Université du Québec à Trois-Rivières, 3351 Boul. Des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada. CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.Department of Chiropractic, Université du Québec à Trois-Rivières, 3351 Boul. Des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada. CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.Department of Chiropractic, Université du Québec à Trois-Rivières, 3351 Boul. Des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada. CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada. Department of Psychology, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.Department of Chiropractic, Université du Québec à Trois-Rivières, 3351 Boul. Des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada. mathieu.piche@uqtr.ca. CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada. mathieu.piche@uqtr.ca.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29450801

Citation

Deldar, Zoha, et al. "Enhancement of Pain Inhibition By Working Memory With Anodal Transcranial Direct Current Stimulation of the Left Dorsolateral Prefrontal Cortex." The Journal of Physiological Sciences : JPS, vol. 68, no. 6, 2018, pp. 825-836.
Deldar Z, Rustamov N, Bois S, et al. Enhancement of pain inhibition by working memory with anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex. J Physiol Sci. 2018;68(6):825-836.
Deldar, Z., Rustamov, N., Bois, S., Blanchette, I., & Piché, M. (2018). Enhancement of pain inhibition by working memory with anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex. The Journal of Physiological Sciences : JPS, 68(6), pp. 825-836. doi:10.1007/s12576-018-0598-4.
Deldar Z, et al. Enhancement of Pain Inhibition By Working Memory With Anodal Transcranial Direct Current Stimulation of the Left Dorsolateral Prefrontal Cortex. J Physiol Sci. 2018;68(6):825-836. PubMed PMID: 29450801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancement of pain inhibition by working memory with anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex. AU - Deldar,Zoha, AU - Rustamov,Nabi, AU - Bois,Suzie, AU - Blanchette,Isabelle, AU - Piché,Mathieu, Y1 - 2018/02/15/ PY - 2017/12/07/received PY - 2018/02/06/accepted PY - 2018/2/17/pubmed PY - 2019/1/24/medline PY - 2018/2/17/entrez KW - Anxiety KW - Cognition KW - Descending modulation KW - Neuromodulation KW - Nociceptive SP - 825 EP - 836 JF - The journal of physiological sciences : JPS JO - J Physiol Sci VL - 68 IS - 6 N2 - The aim of this study was to examine whether transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) enhances pain inhibition by improving working memory (WM). Forty healthy volunteers participated in two tDCS sessions. Pain was evoked by electrical stimulation at the ankle. Participants performed an n-back task (0-back and 2-back). The experimental protocol comprised five counterbalanced conditions (0-back, 2-back, pain, 0-back with pain and 2-back with pain) that were performed twice (pre-tDCS baseline and during tDCS). Compared with the pre-tDCS baseline values, anodal tDCS decreased response times for the 2-back condition (p < 0.01) but not for the 0-back condition (p > 0.5). Anodal tDCS also decreased pain ratings marginally in the 2-back with pain condition, but not the 0-back with pain condition (p = 0.052 and p > 0.2, respectively). No effect was produced by sham tDCS for any condition (p > 0.2). These results indicate that tDCS of the left DLPFC may enhance pain inhibition by improving WM. SN - 1880-6562 UR - https://www.unboundmedicine.com/medline/citation/29450801/Enhancement_of_pain_inhibition_by_working_memory_with_anodal_transcranial_direct_current_stimulation_of_the_left_dorsolateral_prefrontal_cortex_ L2 - https://dx.doi.org/10.1007/s12576-018-0598-4 DB - PRIME DP - Unbound Medicine ER -