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Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE).
Neurobiol Learn Mem. 2018 04; 150:1-12.NL

Abstract

The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which acquisition of the contextual representation and association of the retrieved contextual memory with an immediate foot-shock are separated by 24 h. During the CPFE, learning- related expression patterns of the early growth response-1 gene (Egr-1) vary based on training phase and brain sub-region in adult and adolescent rats (Asok, Schreiber, Jablonski, Rosen, & Stanton, 2013; Schreiber, Asok, Jablonski, Rosen, & Stanton, 2014; Chakraborty, Asok, Stanton, & Rosen, 2016). The current experiments extended our previous findings by examining Egr-1 expression in infant (PD17) and juvenile (PD24) rats during the CPFE using preexposure protocols involving single-exposure (SE) or multiple-exposure (ME) to context. Following a 5 min preexposure to the training context (i.e. the SE protocol), Egr-1 expression in the medial prefrontal cortex (mPFC), dorsal hippocampus (dHPC) and lateral nucleus of the amygdala (LA) was differentially increased in PD24 rats relative to PD17 rats. In contrast, increased Egr-1 expression following an immediate foot-shock (2s, 1.5 mA) did not differ between PD17 and PD24 rats, and was not learning-related. Interestingly, increasing the number of exposures to the training chamber on the preexposure day (i.e. ME protocol) altered training-day expression such that a learning-related increase in expression was observed in the mPFC in PD24 but not PD17 rats. Together, these results illustrate a clear maturation of Egr-1 expression that is both age- and experience-dependent. In addition, the data suggest that regional activity and plasticity within the mPFC on the preexposure but not the training day may contribute to the ontogenetic profile of the effect. Further studies are necessary to elucidate the causal role of sub-region-specific neuroplasticity in the ontogeny of the CPFE.

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Authors+Show Affiliations

Robinson-Drummer PA
Department of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, United States. Electronic address: patrese@udel.edu.
Chakraborty T
Department of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, United States.
Heroux NA
Department of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, United States.
Rosen JB
Department of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, United States.
Stanton ME
Department of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, United States.

MeSH

Age FactorsAmygdalaAnimalsAssociation LearningConditioning, ClassicalEarly Growth Response Protein 1ElectroshockFearFemaleHippocampusMalePrefrontal CortexRatsRats, Long-Evans

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29452227

Citation

Robinson-Drummer, P A., et al. "Age and Experience Dependent Changes in Egr-1 Expression During the Ontogeny of the Context Preexposure Facilitation Effect (CPFE)." Neurobiology of Learning and Memory, vol. 150, 2018, pp. 1-12.
Robinson-Drummer PA, Chakraborty T, Heroux NA, et al. Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE). Neurobiol Learn Mem. 2018;150:1-12.
Robinson-Drummer, P. A., Chakraborty, T., Heroux, N. A., Rosen, J. B., & Stanton, M. E. (2018). Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE). Neurobiology of Learning and Memory, 150, 1-12. https://doi.org/10.1016/j.nlm.2018.02.008
Robinson-Drummer PA, et al. Age and Experience Dependent Changes in Egr-1 Expression During the Ontogeny of the Context Preexposure Facilitation Effect (CPFE). Neurobiol Learn Mem. 2018;150:1-12. PubMed PMID: 29452227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE). AU - Robinson-Drummer,P A, AU - Chakraborty,T, AU - Heroux,N A, AU - Rosen,J B, AU - Stanton,M E, Y1 - 2018/02/13/ PY - 2017/08/08/received PY - 2018/01/29/revised PY - 2018/02/08/accepted PY - 2018/2/17/pubmed PY - 2019/9/17/medline PY - 2018/2/17/entrez KW - CPFE KW - Contextual fear conditioning KW - Egr-1 KW - Learning KW - Ontogeny SP - 1 EP - 12 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 150 N2 - The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which acquisition of the contextual representation and association of the retrieved contextual memory with an immediate foot-shock are separated by 24 h. During the CPFE, learning- related expression patterns of the early growth response-1 gene (Egr-1) vary based on training phase and brain sub-region in adult and adolescent rats (Asok, Schreiber, Jablonski, Rosen, & Stanton, 2013; Schreiber, Asok, Jablonski, Rosen, & Stanton, 2014; Chakraborty, Asok, Stanton, & Rosen, 2016). The current experiments extended our previous findings by examining Egr-1 expression in infant (PD17) and juvenile (PD24) rats during the CPFE using preexposure protocols involving single-exposure (SE) or multiple-exposure (ME) to context. Following a 5 min preexposure to the training context (i.e. the SE protocol), Egr-1 expression in the medial prefrontal cortex (mPFC), dorsal hippocampus (dHPC) and lateral nucleus of the amygdala (LA) was differentially increased in PD24 rats relative to PD17 rats. In contrast, increased Egr-1 expression following an immediate foot-shock (2s, 1.5 mA) did not differ between PD17 and PD24 rats, and was not learning-related. Interestingly, increasing the number of exposures to the training chamber on the preexposure day (i.e. ME protocol) altered training-day expression such that a learning-related increase in expression was observed in the mPFC in PD24 but not PD17 rats. Together, these results illustrate a clear maturation of Egr-1 expression that is both age- and experience-dependent. In addition, the data suggest that regional activity and plasticity within the mPFC on the preexposure but not the training day may contribute to the ontogenetic profile of the effect. Further studies are necessary to elucidate the causal role of sub-region-specific neuroplasticity in the ontogeny of the CPFE. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/29452227/Age_and_experience_dependent_changes_in_Egr_1_expression_during_the_ontogeny_of_the_context_preexposure_facilitation_effect__CPFE__ DB - PRIME DP - Unbound Medicine ER -