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Oxidative stress is increased in sarcopenia and associated with cardiovascular disease risk in sarcopenic obesity.
Maturitas. 2018 Mar; 109:6-12.M

Abstract

OBJECTIVES

To define whether circulating markers of oxidative stress correlate with sarcopenia in terms of glutathione balance and oxidative protein damage, and whether these biomarkers are associated with risk of cardiovascular disease (CVD).

STUDY DESIGN

Population-based cross-sectional study. 115 out of 347 elderly subjects were classified as non-sarcopenic non-obese (NS-NO), sarcopenic non-obese (S-NO), non-sarcopenic obese (NS-O), and sarcopenic obese (S-O).

MAIN OUTCOME MEASUREMENTS

Sarcopenia was defined as a relative skeletal muscle mass index (RASM) <7.25kg/m2 for men or <5.67kg/m2 for women, while obesity was diagnosed in those presenting with% fat >27 for men or >38 for women. The CVD risk was estimated by the carotid intima-media thickness (IMT) and the Framingham score. Blood reduced glutathione (GSH), oxidized glutathione (GSSG), plasma malondialdehyde-(MDA) and 4-hydroxy-2,3-nonenal-(HNE) protein adducts were analyzed.

RESULTS

Significantly greater blood GSSG/GSH ratio and plasma MDA/HNE protein adducts were observed in sarcopenic than in non-sarcopenic patients. A logistic regression model showed a close relationship between serum HNE and MDA adducts and sarcopenia (OR=1.133, 95% CI 1.057-1.215, and OR=1.592, 95% CI 1.015-1.991, respectively). Linear and logistic regression analysis evidenced strong associations between the IMT or the Framingham CVD risk category and blood GSSG/GSH or serum HNE protein adducts in the S-O group.

CONCLUSION

Circulating markers of oxidative stress are increased in sarcopenia and related to CVD risk in sarcopenic obesity, suggesting that redox balance analysis would be a useful part of a multidimensional evaluation in aging. Further research is encouraged to support interventional strategies to correct redox imbalance, which might contribute to the prevention or at least limitation of sarcopenia and its co-morbidities.

Authors+Show Affiliations

Department of Medical and Surgical Sciences, University of Foggia, Italy. Electronic address: francesco.bellanti@unifg.it.Department of Medical and Surgical Sciences, University of Foggia, Italy.Department of Medical and Surgical Sciences, University of Foggia, Italy.Department of Medical and Surgical Sciences, University of Foggia, Italy; IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy; Department of Clinical and Experimental Medicine, University of Foggia, Italy.IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.Department of Medical and Surgical Sciences, University of Foggia, Italy.Department of Medical and Surgical Sciences, University of Foggia, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29452783

Citation

Bellanti, Francesco, et al. "Oxidative Stress Is Increased in Sarcopenia and Associated With Cardiovascular Disease Risk in Sarcopenic Obesity." Maturitas, vol. 109, 2018, pp. 6-12.
Bellanti F, Romano AD, Lo Buglio A, et al. Oxidative stress is increased in sarcopenia and associated with cardiovascular disease risk in sarcopenic obesity. Maturitas. 2018;109:6-12.
Bellanti, F., Romano, A. D., Lo Buglio, A., Castriotta, V., Guglielmi, G., Greco, A., Serviddio, G., & Vendemiale, G. (2018). Oxidative stress is increased in sarcopenia and associated with cardiovascular disease risk in sarcopenic obesity. Maturitas, 109, 6-12. https://doi.org/10.1016/j.maturitas.2017.12.002
Bellanti F, et al. Oxidative Stress Is Increased in Sarcopenia and Associated With Cardiovascular Disease Risk in Sarcopenic Obesity. Maturitas. 2018;109:6-12. PubMed PMID: 29452783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress is increased in sarcopenia and associated with cardiovascular disease risk in sarcopenic obesity. AU - Bellanti,Francesco, AU - Romano,Antonino D, AU - Lo Buglio,Aurelio, AU - Castriotta,Valeria, AU - Guglielmi,Giuseppe, AU - Greco,Antonio, AU - Serviddio,Gaetano, AU - Vendemiale,Gianluigi, Y1 - 2017/12/05/ PY - 2017/05/31/received PY - 2017/11/26/revised PY - 2017/12/03/accepted PY - 2018/2/18/entrez PY - 2018/2/18/pubmed PY - 2018/6/14/medline KW - Cardiovascular risk KW - Glutathione KW - Oxidative stress KW - Sarcopenia SP - 6 EP - 12 JF - Maturitas JO - Maturitas VL - 109 N2 - OBJECTIVES: To define whether circulating markers of oxidative stress correlate with sarcopenia in terms of glutathione balance and oxidative protein damage, and whether these biomarkers are associated with risk of cardiovascular disease (CVD). STUDY DESIGN: Population-based cross-sectional study. 115 out of 347 elderly subjects were classified as non-sarcopenic non-obese (NS-NO), sarcopenic non-obese (S-NO), non-sarcopenic obese (NS-O), and sarcopenic obese (S-O). MAIN OUTCOME MEASUREMENTS: Sarcopenia was defined as a relative skeletal muscle mass index (RASM) <7.25kg/m2 for men or <5.67kg/m2 for women, while obesity was diagnosed in those presenting with% fat >27 for men or >38 for women. The CVD risk was estimated by the carotid intima-media thickness (IMT) and the Framingham score. Blood reduced glutathione (GSH), oxidized glutathione (GSSG), plasma malondialdehyde-(MDA) and 4-hydroxy-2,3-nonenal-(HNE) protein adducts were analyzed. RESULTS: Significantly greater blood GSSG/GSH ratio and plasma MDA/HNE protein adducts were observed in sarcopenic than in non-sarcopenic patients. A logistic regression model showed a close relationship between serum HNE and MDA adducts and sarcopenia (OR=1.133, 95% CI 1.057-1.215, and OR=1.592, 95% CI 1.015-1.991, respectively). Linear and logistic regression analysis evidenced strong associations between the IMT or the Framingham CVD risk category and blood GSSG/GSH or serum HNE protein adducts in the S-O group. CONCLUSION: Circulating markers of oxidative stress are increased in sarcopenia and related to CVD risk in sarcopenic obesity, suggesting that redox balance analysis would be a useful part of a multidimensional evaluation in aging. Further research is encouraged to support interventional strategies to correct redox imbalance, which might contribute to the prevention or at least limitation of sarcopenia and its co-morbidities. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/29452783/Oxidative_stress_is_increased_in_sarcopenia_and_associated_with_cardiovascular_disease_risk_in_sarcopenic_obesity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(17)30645-X DB - PRIME DP - Unbound Medicine ER -