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Towards elimination of schistosomiasis after 5000 years of endemicity in Egypt.
Acta Trop. 2018 May; 181:112-121.AT

Abstract

Schistosomiasis is a snail-transmitted infectious disease caused by a long lasting infection with a blood fluke of the genus Schistosoma. S. haematobium and S. mansoni are the species endemic in Egypt. The country has been plagued and seriously suffered from schistosomiasis over the past 5000 years. Great strides had been done in controlling the disease since 1922. The history, epidemiology and the different control approaches were reviewed. Currently, Egypt is preparing towards schistosomiasis elimination by 2020. The new strategy depends on four main axes; large scale treatment in all areas of residual transmission by targeting entire populations with PZQ, intensified snail control, heath education and behavioral changes and expansion of the complementary public health interventions. While on the road towards elimination, we addressed here the important challenges, lessons and the key issues from the different control strategies to help the achievement of our goal. Notably, frangibility of the drug based control, emergence of resistance against PZQ, persistence of some hot spots areas, the need of further control efforts to the high risk individuals and community involvement in the control programs, reconsideration of diagnostic tests used in surveillance, and continous monitoring of the field to detect changes in the snail intermediate host. Importantly, the adaptation between the parasite and its intermediate snail host throughout water bodies in Egypt merits attention as Schistosoma infection can be introduced to the new reclaimed areas. This review may help supplying information for the policy makers to tailor control measures suitable to the local context that could help in the transfer from control to elimination.

Authors+Show Affiliations

Medical Parasitology Department, Faculty of Medicine, Alexandria University, Egypt. Electronic address: eman.abuelnaga@alexmed.edu.eg.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29453950

Citation

Abou-El-Naga, Iman F.. "Towards Elimination of Schistosomiasis After 5000 Years of Endemicity in Egypt." Acta Tropica, vol. 181, 2018, pp. 112-121.
Abou-El-Naga IF. Towards elimination of schistosomiasis after 5000 years of endemicity in Egypt. Acta Trop. 2018;181:112-121.
Abou-El-Naga, I. F. (2018). Towards elimination of schistosomiasis after 5000 years of endemicity in Egypt. Acta Tropica, 181, 112-121. https://doi.org/10.1016/j.actatropica.2018.02.005
Abou-El-Naga IF. Towards Elimination of Schistosomiasis After 5000 Years of Endemicity in Egypt. Acta Trop. 2018;181:112-121. PubMed PMID: 29453950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Towards elimination of schistosomiasis after 5000 years of endemicity in Egypt. A1 - Abou-El-Naga,Iman F, Y1 - 2018/02/14/ PY - 2017/10/06/received PY - 2018/01/29/revised PY - 2018/02/11/accepted PY - 2018/2/18/pubmed PY - 2018/8/17/medline PY - 2018/2/18/entrez KW - Control strategies KW - Egypt KW - Elimination of schistosomiasis KW - Schistosoma hematobium KW - Schistosoma mansoni SP - 112 EP - 121 JF - Acta tropica JO - Acta Trop. VL - 181 N2 - Schistosomiasis is a snail-transmitted infectious disease caused by a long lasting infection with a blood fluke of the genus Schistosoma. S. haematobium and S. mansoni are the species endemic in Egypt. The country has been plagued and seriously suffered from schistosomiasis over the past 5000 years. Great strides had been done in controlling the disease since 1922. The history, epidemiology and the different control approaches were reviewed. Currently, Egypt is preparing towards schistosomiasis elimination by 2020. The new strategy depends on four main axes; large scale treatment in all areas of residual transmission by targeting entire populations with PZQ, intensified snail control, heath education and behavioral changes and expansion of the complementary public health interventions. While on the road towards elimination, we addressed here the important challenges, lessons and the key issues from the different control strategies to help the achievement of our goal. Notably, frangibility of the drug based control, emergence of resistance against PZQ, persistence of some hot spots areas, the need of further control efforts to the high risk individuals and community involvement in the control programs, reconsideration of diagnostic tests used in surveillance, and continous monitoring of the field to detect changes in the snail intermediate host. Importantly, the adaptation between the parasite and its intermediate snail host throughout water bodies in Egypt merits attention as Schistosoma infection can be introduced to the new reclaimed areas. This review may help supplying information for the policy makers to tailor control measures suitable to the local context that could help in the transfer from control to elimination. SN - 1873-6254 UR - https://www.unboundmedicine.com/medline/citation/29453950/Towards_elimination_of_schistosomiasis_after_5000_years_of_endemicity_in_Egypt_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(17)31203-2 DB - PRIME DP - Unbound Medicine ER -
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