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Three new quinazolines from Evodia rutaecarpa and their biological activity.
Fitoterapia. 2018 Jun; 127:186-192.F

Abstract

In this research, we investigated the profile and bioactivities of quinazoline alkaloids, a class of natural products boasting multiple bioactivities, from the unripe fruit of Evodia rutaecarpa (Juss.) Benth. Three new quinazoline alkaloids, evodiamide A (1), evodiamide B (2), and evodiamide C (3), as well as eight known quinazolines, were isolated from the MeOH extract of E. rutaecarpa. The new compounds are rare quinazolinedione derivatives with linked heterocyclic nuclei. Among these quinazolines, rhetsinine (8) showed potential as a pesticide and exhibited excellent inhibition against Xanthomonas oryzae pv. oryzae, Xanthomonas oryzae pv. oryzicola, and Xanthomonas campestris pv. campestris, with respective EC50 values of 3.13, 14.32, and 32.72 nmol.

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Authors+Show Affiliations

Su XL
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, People's Republic of China.
Xu S
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, People's Republic of China.
Shan Y
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, People's Republic of China.
Yin M
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, People's Republic of China.
Chen Y
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, People's Republic of China.
Feng X
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, People's Republic of China. Electronic address: fengxucnbg@cnbg.net.
Wang QZ
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, People's Republic of China. Electronic address: wangqizhi@cnbg.net.

MeSH

AlkaloidsAnti-Bacterial AgentsEvodiaFruitMolecular StructurePlant ExtractsQuinazolinesXanthomonas

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29454021

Citation

Su, Xiu-Li, et al. "Three New Quinazolines From Evodia Rutaecarpa and Their Biological Activity." Fitoterapia, vol. 127, 2018, pp. 186-192.
Su XL, Xu S, Shan Y, et al. Three new quinazolines from Evodia rutaecarpa and their biological activity. Fitoterapia. 2018;127:186-192.
Su, X. L., Xu, S., Shan, Y., Yin, M., Chen, Y., Feng, X., & Wang, Q. Z. (2018). Three new quinazolines from Evodia rutaecarpa and their biological activity. Fitoterapia, 127, 186-192. https://doi.org/10.1016/j.fitote.2018.02.003
Su XL, et al. Three New Quinazolines From Evodia Rutaecarpa and Their Biological Activity. Fitoterapia. 2018;127:186-192. PubMed PMID: 29454021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three new quinazolines from Evodia rutaecarpa and their biological activity. AU - Su,Xiu-Li, AU - Xu,Shu, AU - Shan,Yu, AU - Yin,Min, AU - Chen,Yu, AU - Feng,Xu, AU - Wang,Qi-Zhi, Y1 - 2018/02/14/ PY - 2017/12/14/received PY - 2018/01/23/revised PY - 2018/02/03/accepted PY - 2018/2/18/pubmed PY - 2018/7/22/medline PY - 2018/2/18/entrez KW - Antibacterial KW - Evodia rutaecarpa KW - Evodiamide A KW - Evodiamide B KW - Evodiamide C KW - Rutaceae SP - 186 EP - 192 JF - Fitoterapia JO - Fitoterapia VL - 127 N2 - In this research, we investigated the profile and bioactivities of quinazoline alkaloids, a class of natural products boasting multiple bioactivities, from the unripe fruit of Evodia rutaecarpa (Juss.) Benth. Three new quinazoline alkaloids, evodiamide A (1), evodiamide B (2), and evodiamide C (3), as well as eight known quinazolines, were isolated from the MeOH extract of E. rutaecarpa. The new compounds are rare quinazolinedione derivatives with linked heterocyclic nuclei. Among these quinazolines, rhetsinine (8) showed potential as a pesticide and exhibited excellent inhibition against Xanthomonas oryzae pv. oryzae, Xanthomonas oryzae pv. oryzicola, and Xanthomonas campestris pv. campestris, with respective EC50 values of 3.13, 14.32, and 32.72 nmol. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/29454021/Three_new_quinazolines_from_Evodia_rutaecarpa_and_their_biological_activity_ DB - PRIME DP - Unbound Medicine ER -