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Fabricating 3D printed orally disintegrating printlets using selective laser sintering.
Int J Pharm. 2018 Apr 25; 541(1-2):101-107.IJ

Abstract

Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of using SLS to fabricate novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon® VA 64)) were separately mixed with 5% paracetamol (used as a model drug) and 3% Candurin® Gold Sheen colorant; the powder mixes were subjected to SLS printing, resulting in the manufacture of printlets (3DP tablets). Modulating the SLS printing parameters altered the release characteristics of the printlets, with faster laser scanning speeds accelerating drug release from the HPMC formulations. The same trend was observed for the Kollidon® based printlets. At a laser scanning speed of 300 mm/s, the Kollidon® printlets exhibited orally disintegrating characteristics by completely dispersing in <4 s in a small volume of water. X-ray micro-CT analysis of these printlets indicated a reduction in their density and an increase in open porosity, therefore, confirming the unique disintegration behaviour of these formulations. The work reported here is the first to demonstrate the feasibility of SLS 3DP to fabricate printlets with accelerated drug release and orally disintegrating properties. This investigation has confirmed that SLS is amenable to the pharmaceutical research of modern medicine manufacture.

Authors+Show Affiliations

Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK. Electronic address: a.goyanes@FabRx.co.uk.Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK; FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK.Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK; FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK. Electronic address: a.basit@ucl.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29454028

Citation

Fina, Fabrizio, et al. "Fabricating 3D Printed Orally Disintegrating Printlets Using Selective Laser Sintering." International Journal of Pharmaceutics, vol. 541, no. 1-2, 2018, pp. 101-107.
Fina F, Madla CM, Goyanes A, et al. Fabricating 3D printed orally disintegrating printlets using selective laser sintering. Int J Pharm. 2018;541(1-2):101-107.
Fina, F., Madla, C. M., Goyanes, A., Zhang, J., Gaisford, S., & Basit, A. W. (2018). Fabricating 3D printed orally disintegrating printlets using selective laser sintering. International Journal of Pharmaceutics, 541(1-2), 101-107. https://doi.org/10.1016/j.ijpharm.2018.02.015
Fina F, et al. Fabricating 3D Printed Orally Disintegrating Printlets Using Selective Laser Sintering. Int J Pharm. 2018 Apr 25;541(1-2):101-107. PubMed PMID: 29454028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fabricating 3D printed orally disintegrating printlets using selective laser sintering. AU - Fina,Fabrizio, AU - Madla,Christine M, AU - Goyanes,Alvaro, AU - Zhang,Jiaxin, AU - Gaisford,Simon, AU - Basit,Abdul W, Y1 - 2018/02/14/ PY - 2018/01/06/received PY - 2018/02/11/revised PY - 2018/02/12/accepted PY - 2018/2/18/pubmed PY - 2018/9/8/medline PY - 2018/2/18/entrez KW - Additive manufacturing KW - Orally disintegrating tablets KW - Personalised medicines KW - Rapid prototyping KW - Three-dimensional printing SP - 101 EP - 107 JF - International journal of pharmaceutics JO - Int J Pharm VL - 541 IS - 1-2 N2 - Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of using SLS to fabricate novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon® VA 64)) were separately mixed with 5% paracetamol (used as a model drug) and 3% Candurin® Gold Sheen colorant; the powder mixes were subjected to SLS printing, resulting in the manufacture of printlets (3DP tablets). Modulating the SLS printing parameters altered the release characteristics of the printlets, with faster laser scanning speeds accelerating drug release from the HPMC formulations. The same trend was observed for the Kollidon® based printlets. At a laser scanning speed of 300 mm/s, the Kollidon® printlets exhibited orally disintegrating characteristics by completely dispersing in <4 s in a small volume of water. X-ray micro-CT analysis of these printlets indicated a reduction in their density and an increase in open porosity, therefore, confirming the unique disintegration behaviour of these formulations. The work reported here is the first to demonstrate the feasibility of SLS 3DP to fabricate printlets with accelerated drug release and orally disintegrating properties. This investigation has confirmed that SLS is amenable to the pharmaceutical research of modern medicine manufacture. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/29454028/Fabricating_3D_printed_orally_disintegrating_printlets_using_selective_laser_sintering_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(18)30096-6 DB - PRIME DP - Unbound Medicine ER -