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Platelet activity in cluster headache.
Cephalalgia. 1986 Sep; 6(3):163-7.C

Abstract

Platelets are known to be activated in common or classic migraine both during the attack and in headache-free periods. Platelet behavior is less well known in cluster headache. We have investigated beta-thromboglobulin (beta-TG) and platelet factor four (PF4) plasma levels, markers of in vivo platelet activation, in patients during remission and during bouts of cluster headache with and without pain. The results indicated that statistically significantly higher levels of beta-TG and PF4 occur in the patients during the remission period when compared with the control subjects. Such high levels seemed to persist between paroxysmal episodes in cluster periods. However, during the attacks of cluster headache beta-TG and PF4 plasma levels decreased by 42% and 50%, respectively, in comparison with plasma concentrations measured outside of attack. Thus, although platelet activation also occurs in patients with cluster headache, the attack as such seems to be characterized by a marked reduction in platelet activation.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2945644

Citation

D'Andrea, G, et al. "Platelet Activity in Cluster Headache." Cephalalgia : an International Journal of Headache, vol. 6, no. 3, 1986, pp. 163-7.
D'Andrea G, Cananzi AR, Toldo M, et al. Platelet activity in cluster headache. Cephalalgia. 1986;6(3):163-7.
D'Andrea, G., Cananzi, A. R., Toldo, M., & Ferro-Milone, F. (1986). Platelet activity in cluster headache. Cephalalgia : an International Journal of Headache, 6(3), 163-7.
D'Andrea G, et al. Platelet Activity in Cluster Headache. Cephalalgia. 1986;6(3):163-7. PubMed PMID: 2945644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Platelet activity in cluster headache. AU - D'Andrea,G, AU - Cananzi,A R, AU - Toldo,M, AU - Ferro-Milone,F, PY - 1986/9/1/pubmed PY - 1986/9/1/medline PY - 1986/9/1/entrez SP - 163 EP - 7 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 6 IS - 3 N2 - Platelets are known to be activated in common or classic migraine both during the attack and in headache-free periods. Platelet behavior is less well known in cluster headache. We have investigated beta-thromboglobulin (beta-TG) and platelet factor four (PF4) plasma levels, markers of in vivo platelet activation, in patients during remission and during bouts of cluster headache with and without pain. The results indicated that statistically significantly higher levels of beta-TG and PF4 occur in the patients during the remission period when compared with the control subjects. Such high levels seemed to persist between paroxysmal episodes in cluster periods. However, during the attacks of cluster headache beta-TG and PF4 plasma levels decreased by 42% and 50%, respectively, in comparison with plasma concentrations measured outside of attack. Thus, although platelet activation also occurs in patients with cluster headache, the attack as such seems to be characterized by a marked reduction in platelet activation. SN - 0333-1024 UR - https://www.unboundmedicine.com/medline/citation/2945644/Platelet_activity_in_cluster_headache_ L2 - https://journals.sagepub.com/doi/10.1046/j.1468-2982.1986.0603163.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -