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Green leafy and cruciferous vegetable consumption and risk of type 2 diabetes: results from the Singapore Chinese Health Study and meta-analysis.
Br J Nutr. 2018 05; 119(9):1057-1067.BJ

Abstract

Several previous prospective studies suggest that consumption of green leafy and cruciferous vegetables may lower the risk of type 2 diabetes (T2D). We investigated the association between consumption of different types of vegetables in relation to T2D risk in an Asian Population. We included 45 411 participants (age range: 45-74 years) of the Singapore Chinese Health Study (SCHS) free of diabetes, cancer or CVD at baseline (1993-1998). Dietary information was collected using a validated FFQ. Physician-diagnosed incident diabetes was reported at follow-up I (1999-2004) and II (2006-2010) interviews. Cox proportional hazards regression was used to estimate hazard ratio (HR) and 95 % CI of T2D risk. An updated meta-analysis was also conducted to summarise results for green leafy and cruciferous vegetables. During 494 741 person-years of follow-up, 5207 incident T2D occurred. After adjustment for potential confounders, neither total vegetables (top v. bottom quintile HR=1·08; 95 % CI 0·98, 1·18, P trend=0·66) nor specific vegetables including dark green leafy vegetables (HR=1·05; 95 % CI 0·96, 1·15, P trend=0·21) and cruciferous vegetables (HR=0·97; 95 % CI 0·88, 1·06, P trend=0·29) were substantially associated with risk of T2D. A meta-analysis (eleven studies with 754 729 participants and 58 297 cases) including the SCHS and all previous prospective studies suggested borderline significant inverse associations between green leafy (summary relative risk (RR)=0·91; 95 % CI 0·84, 1·00) and cruciferous vegetable consumption (RR=0·87; 95 % CI 0·76, 1·00) and T2D risk, with moderate-to-high heterogeneity. In conclusion, green leafy or cruciferous vegetable consumption was not substantially associated with risk of T2D in an Asian population. Meta-analysis of available cohort data indicated that evidence for a beneficial effect of green leafy or cruciferous vegetable consumption on T2D risk is not convincing.

Authors+Show Affiliations

1Department of Nutrition and Food Hygiene,School of Public Health,Soochow University,Suzhou,215123,People's Republic of China.2Saw Swee Hock School of Public Health,National University of Singapore,Singapore 117549,Singapore.4Division of Cancer Control and Population Sciences,University of Pittsburgh Cancer Institute,Pittsburgh, PA 15232,USA.1Department of Nutrition and Food Hygiene,School of Public Health,Soochow University,Suzhou,215123,People's Republic of China.2Saw Swee Hock School of Public Health,National University of Singapore,Singapore 117549,Singapore.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29457582

Citation

Chen, Guo-Chong, et al. "Green Leafy and Cruciferous Vegetable Consumption and Risk of Type 2 Diabetes: Results From the Singapore Chinese Health Study and Meta-analysis." The British Journal of Nutrition, vol. 119, no. 9, 2018, pp. 1057-1067.
Chen GC, Koh WP, Yuan JM, et al. Green leafy and cruciferous vegetable consumption and risk of type 2 diabetes: results from the Singapore Chinese Health Study and meta-analysis. Br J Nutr. 2018;119(9):1057-1067.
Chen, G. C., Koh, W. P., Yuan, J. M., Qin, L. Q., & van Dam, R. M. (2018). Green leafy and cruciferous vegetable consumption and risk of type 2 diabetes: results from the Singapore Chinese Health Study and meta-analysis. The British Journal of Nutrition, 119(9), 1057-1067. https://doi.org/10.1017/S0007114518000119
Chen GC, et al. Green Leafy and Cruciferous Vegetable Consumption and Risk of Type 2 Diabetes: Results From the Singapore Chinese Health Study and Meta-analysis. Br J Nutr. 2018;119(9):1057-1067. PubMed PMID: 29457582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green leafy and cruciferous vegetable consumption and risk of type 2 diabetes: results from the Singapore Chinese Health Study and meta-analysis. AU - Chen,Guo-Chong, AU - Koh,Woon-Puay, AU - Yuan,Jian-Min, AU - Qin,Li-Qiang, AU - van Dam,Rob M, Y1 - 2018/02/19/ PY - 2018/2/20/pubmed PY - 2019/4/4/medline PY - 2018/2/20/entrez KW - HR hazard ratio KW - RR relative risk KW - SCHS Singapore Chinese Health Study KW - SWHS Shanghai Women’s Health Study KW - T2D type 2 diabetes KW - Cohort studies KW - Diets KW - Meta-analyses KW - Type 2 diabetes KW - Vegetables SP - 1057 EP - 1067 JF - The British journal of nutrition JO - Br J Nutr VL - 119 IS - 9 N2 - Several previous prospective studies suggest that consumption of green leafy and cruciferous vegetables may lower the risk of type 2 diabetes (T2D). We investigated the association between consumption of different types of vegetables in relation to T2D risk in an Asian Population. We included 45 411 participants (age range: 45-74 years) of the Singapore Chinese Health Study (SCHS) free of diabetes, cancer or CVD at baseline (1993-1998). Dietary information was collected using a validated FFQ. Physician-diagnosed incident diabetes was reported at follow-up I (1999-2004) and II (2006-2010) interviews. Cox proportional hazards regression was used to estimate hazard ratio (HR) and 95 % CI of T2D risk. An updated meta-analysis was also conducted to summarise results for green leafy and cruciferous vegetables. During 494 741 person-years of follow-up, 5207 incident T2D occurred. After adjustment for potential confounders, neither total vegetables (top v. bottom quintile HR=1·08; 95 % CI 0·98, 1·18, P trend=0·66) nor specific vegetables including dark green leafy vegetables (HR=1·05; 95 % CI 0·96, 1·15, P trend=0·21) and cruciferous vegetables (HR=0·97; 95 % CI 0·88, 1·06, P trend=0·29) were substantially associated with risk of T2D. A meta-analysis (eleven studies with 754 729 participants and 58 297 cases) including the SCHS and all previous prospective studies suggested borderline significant inverse associations between green leafy (summary relative risk (RR)=0·91; 95 % CI 0·84, 1·00) and cruciferous vegetable consumption (RR=0·87; 95 % CI 0·76, 1·00) and T2D risk, with moderate-to-high heterogeneity. In conclusion, green leafy or cruciferous vegetable consumption was not substantially associated with risk of T2D in an Asian population. Meta-analysis of available cohort data indicated that evidence for a beneficial effect of green leafy or cruciferous vegetable consumption on T2D risk is not convincing. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/29457582/Green_leafy_and_cruciferous_vegetable_consumption_and_risk_of_type_2_diabetes:_results_from_the_Singapore_Chinese_Health_Study_and_meta_analysis_ L2 - https://www.cambridge.org/core/product/identifier/S0007114518000119/type/journal_article DB - PRIME DP - Unbound Medicine ER -