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In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years.
Environ Health. 2018 02 20; 17(1):17.EH

Abstract

BACKGROUND

There are concerns that developmental exposure to endocrine disrupting chemicals such as phenolic compounds and phthalates could affect child cognitive function. Epidemiological studies tackling this question have mainly focused on phthalate metabolites and bisphenol A, but not on the other phenolic compounds. Our study aimed to assess the relationship between in-utero exposure to phthalates, bisphenol A and other phenolic compounds (parabens, triclosan, dichlorophenols and benzophenone-3) and the Intelligence Quotient (IQ) of boys at 5-6 years.

METHODS

In 452 mother-son dyads from the French EDEN cohort, we measured 11 phthalate metabolites and 9 phenolic compounds (4 parabens, benzophenone-3, bisphenol A, 2 dichlorophenols and triclosan) in spot urine samples collected between 22 and 29 gestational weeks. Verbal and performance IQ of children were assessed at 5-6 years by a psychologist using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). We used adjusted Structural Equation Models (SEM) combined with Benjamini and Hochberg false discovery rate correction to assess the associations between maternal urine phenol and phthalate metabolite concentrations considered simultaneously and the boys' IQ.

RESULTS

No phenol or phthalate metabolite concentration was negatively associated with the boys' verbal or performance IQ (uncorrected p-values ≥0.09). Mono(3-carboxypropyl) phthalate tended to be associated with increased verbal IQ (β = 0.136, 95% confidence interval, 0.01; 0.27). This association disappeared after correction for multiple comparison (corrected p-value, 0.71).

CONCLUSION

Our results did not provide evidence of an inverse association between in-utero exposure to phenols or phthalates and verbal and performance IQ among boys. Since phenols and phthalates may have sex-specific effects, these null findings cannot be generalized to girls. Limitations included use of a single spot urine sample to assess exposures and lack of consideration of postnatal exposures.

Authors+Show Affiliations

Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, 38000, Grenoble, France. dorothy.nakiwala@univ-grenoble-alpes.fr.Assistance Publique-Hôpitaux de Paris, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France. Cognitive Sciences and Psycholinguistic Laboratory, Ecole Normale Supérieure, Paris, France.U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre (CRESS), Early Origin of the Child's Health and Development (ORCHAD) Team, Inserm, Villejuif, France. Université Paris Descartes, Villejuif, France.U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre (CRESS), Early Origin of the Child's Health and Development (ORCHAD) Team, Inserm, Villejuif, France. Université Paris Descartes, Villejuif, France. Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.Inserm U1085-IRSET, Université Rennes 1, Rennes, France.Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, 38000, Grenoble, France.Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, 38000, Grenoble, France.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29458359

Citation

Nakiwala, Dorothy, et al. "In-utero Exposure to Phenols and Phthalates and the Intelligence Quotient of Boys at 5 Years." Environmental Health : a Global Access Science Source, vol. 17, no. 1, 2018, p. 17.
Nakiwala D, Peyre H, Heude B, et al. In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years. Environ Health. 2018;17(1):17.
Nakiwala, D., Peyre, H., Heude, B., Bernard, J. Y., Béranger, R., Slama, R., & Philippat, C. (2018). In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years. Environmental Health : a Global Access Science Source, 17(1), 17. https://doi.org/10.1186/s12940-018-0359-0
Nakiwala D, et al. In-utero Exposure to Phenols and Phthalates and the Intelligence Quotient of Boys at 5 Years. Environ Health. 2018 02 20;17(1):17. PubMed PMID: 29458359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years. AU - Nakiwala,Dorothy, AU - Peyre,Hugo, AU - Heude,Barbara, AU - Bernard,Jonathan Y, AU - Béranger,Rémi, AU - Slama,Rémy, AU - Philippat,Claire, AU - ,, Y1 - 2018/02/20/ PY - 2017/09/08/received PY - 2018/01/29/accepted PY - 2018/2/21/entrez PY - 2018/2/21/pubmed PY - 2018/12/18/medline KW - Bisphenol A KW - Cognitive function KW - Endocrine disruptors KW - Intelligence quotient KW - Parabens KW - Phthalate KW - Prenatal exposure KW - Triclosan SP - 17 EP - 17 JF - Environmental health : a global access science source JO - Environ Health VL - 17 IS - 1 N2 - BACKGROUND: There are concerns that developmental exposure to endocrine disrupting chemicals such as phenolic compounds and phthalates could affect child cognitive function. Epidemiological studies tackling this question have mainly focused on phthalate metabolites and bisphenol A, but not on the other phenolic compounds. Our study aimed to assess the relationship between in-utero exposure to phthalates, bisphenol A and other phenolic compounds (parabens, triclosan, dichlorophenols and benzophenone-3) and the Intelligence Quotient (IQ) of boys at 5-6 years. METHODS: In 452 mother-son dyads from the French EDEN cohort, we measured 11 phthalate metabolites and 9 phenolic compounds (4 parabens, benzophenone-3, bisphenol A, 2 dichlorophenols and triclosan) in spot urine samples collected between 22 and 29 gestational weeks. Verbal and performance IQ of children were assessed at 5-6 years by a psychologist using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). We used adjusted Structural Equation Models (SEM) combined with Benjamini and Hochberg false discovery rate correction to assess the associations between maternal urine phenol and phthalate metabolite concentrations considered simultaneously and the boys' IQ. RESULTS: No phenol or phthalate metabolite concentration was negatively associated with the boys' verbal or performance IQ (uncorrected p-values ≥0.09). Mono(3-carboxypropyl) phthalate tended to be associated with increased verbal IQ (β = 0.136, 95% confidence interval, 0.01; 0.27). This association disappeared after correction for multiple comparison (corrected p-value, 0.71). CONCLUSION: Our results did not provide evidence of an inverse association between in-utero exposure to phenols or phthalates and verbal and performance IQ among boys. Since phenols and phthalates may have sex-specific effects, these null findings cannot be generalized to girls. Limitations included use of a single spot urine sample to assess exposures and lack of consideration of postnatal exposures. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/29458359/In_utero_exposure_to_phenols_and_phthalates_and_the_intelligence_quotient_of_boys_at_5_years_ L2 - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-018-0359-0 DB - PRIME DP - Unbound Medicine ER -