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Effect of high dose vitamin D3 therapy on serum vitamin D3 levels in vitamin D insufficient adults with cystic fibrosis.
Clin Nutr ESPEN 2018; 23:84-88CN

Abstract

BACKGROUND

The effect of a high dose oral cholecalciferol repletion strategy in Vitamin D insufficient adults with CF is still unknown. Therefore, we assessed the effectiveness of our current approach, giving oral vitamin D3 supplementation at a dose of 10,000 IU from Monday to Friday for a total of 50,000 IU D3 weekly in vitamin D insufficient adult with CF.

METHODS

We performed a retrospective chart review of all 59 adult CF patients between the ages of 17 and 64 years routinely followed at the CF Adult Program of Winnipeg Health Sciences Centre. Through consultation with the endocrinologist, our clinic vitamin D repletion protocol for treating CF adult patients who have serum 25-hydroxyvitamin D (25-OHD) < 30 ng/ml (<75 nmol/L) was to prescribe vitamin D3 10,000 IU orally from Monday to Friday (or the weekly equivalent of 50,000 IU) for 12 weeks in addition to their regular CF vitamin that supplied from 800 to 2000 IU vitamin D3 daily. Cholecalciferol was conveniently administered orally as either one capsule (oil-based) 10,000 IU or one tablet (powder-based) 10,000 IU. All patients were instructed to obtain follow-up serum 25-OHD levels post completion of treatment.

RESULTS

Of the 59 adult patients at our CF Clinic, 35 patients (59%) had below optimal serum 25-OHD levels. Of the 35 patients identified, 10 patients with insufficient serum 25-OHD levels between 10 and 30 ng/ml (25-75 nmol/L) fulfilled the inclusion criteria. A significant increase in serum 25-OHD levels was observed (P < 0.01) from mean value of 21.6 ± 5.9 ng/ml (54.1 ± 14.8 nmol/L) at baseline to 31.7 ± 9.1 ng/ml (79.3 ± 22.8 nmol/L) ≥ 2 months post intervention. The current treatment approach was successful in treating Vitamin D insufficiency in 70% of the patients with low 25-OHD levels.

CONCLUSION

The results of this study demonstrate that a large number of adults attending Winnipeg Health Sciences Centre CF Clinic have serum 25-OHD levels below 30 ng/ml (75 nmol/L). This supports the need for dedicated and individualized approach to manage this condition. High dose therapy of vitamin D3, although a more aggressive treatment approach, may result in achieving optimal levels of serum 25-OHD in adults with CF.

Authors+Show Affiliations

Nutrition and Food Services, Health Sciences Centre, Winnipeg, Manitoba, Canada. Electronic address: rlam@hsc.mb.ca.Internal Medicine, University of Manitoba, Canada.Pediatrics and Child Health, University of Manitoba, Canada.Diagnostic Services of Manitoba, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29460819

Citation

Regalado Lam Chew Tun, Rhiza, et al. "Effect of High Dose Vitamin D3 Therapy On Serum Vitamin D3 Levels in Vitamin D Insufficient Adults With Cystic Fibrosis." Clinical Nutrition ESPEN, vol. 23, 2018, pp. 84-88.
Regalado Lam Chew Tun R, Porhownik N, Taback S, et al. Effect of high dose vitamin D3 therapy on serum vitamin D3 levels in vitamin D insufficient adults with cystic fibrosis. Clin Nutr ESPEN. 2018;23:84-88.
Regalado Lam Chew Tun, R., Porhownik, N., Taback, S., & Oleschuk, C. (2018). Effect of high dose vitamin D3 therapy on serum vitamin D3 levels in vitamin D insufficient adults with cystic fibrosis. Clinical Nutrition ESPEN, 23, pp. 84-88. doi:10.1016/j.clnesp.2017.12.001.
Regalado Lam Chew Tun R, et al. Effect of High Dose Vitamin D3 Therapy On Serum Vitamin D3 Levels in Vitamin D Insufficient Adults With Cystic Fibrosis. Clin Nutr ESPEN. 2018;23:84-88. PubMed PMID: 29460819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of high dose vitamin D3 therapy on serum vitamin D3 levels in vitamin D insufficient adults with cystic fibrosis. AU - Regalado Lam Chew Tun,Rhiza, AU - Porhownik,Nancy, AU - Taback,Shayne, AU - Oleschuk,Curtis, Y1 - 2017/12/26/ PY - 2017/08/15/received PY - 2017/11/14/revised PY - 2017/12/01/accepted PY - 2018/2/21/entrez PY - 2018/2/21/pubmed PY - 2018/2/21/medline KW - 25-Hydroxyvitamin D KW - Cystic fibrosis KW - Vitamin D insufficiency KW - Vitamin D supplementation SP - 84 EP - 88 JF - Clinical nutrition ESPEN JO - Clin Nutr ESPEN VL - 23 N2 - BACKGROUND: The effect of a high dose oral cholecalciferol repletion strategy in Vitamin D insufficient adults with CF is still unknown. Therefore, we assessed the effectiveness of our current approach, giving oral vitamin D3 supplementation at a dose of 10,000 IU from Monday to Friday for a total of 50,000 IU D3 weekly in vitamin D insufficient adult with CF. METHODS: We performed a retrospective chart review of all 59 adult CF patients between the ages of 17 and 64 years routinely followed at the CF Adult Program of Winnipeg Health Sciences Centre. Through consultation with the endocrinologist, our clinic vitamin D repletion protocol for treating CF adult patients who have serum 25-hydroxyvitamin D (25-OHD) < 30 ng/ml (<75 nmol/L) was to prescribe vitamin D3 10,000 IU orally from Monday to Friday (or the weekly equivalent of 50,000 IU) for 12 weeks in addition to their regular CF vitamin that supplied from 800 to 2000 IU vitamin D3 daily. Cholecalciferol was conveniently administered orally as either one capsule (oil-based) 10,000 IU or one tablet (powder-based) 10,000 IU. All patients were instructed to obtain follow-up serum 25-OHD levels post completion of treatment. RESULTS: Of the 59 adult patients at our CF Clinic, 35 patients (59%) had below optimal serum 25-OHD levels. Of the 35 patients identified, 10 patients with insufficient serum 25-OHD levels between 10 and 30 ng/ml (25-75 nmol/L) fulfilled the inclusion criteria. A significant increase in serum 25-OHD levels was observed (P < 0.01) from mean value of 21.6 ± 5.9 ng/ml (54.1 ± 14.8 nmol/L) at baseline to 31.7 ± 9.1 ng/ml (79.3 ± 22.8 nmol/L) ≥ 2 months post intervention. The current treatment approach was successful in treating Vitamin D insufficiency in 70% of the patients with low 25-OHD levels. CONCLUSION: The results of this study demonstrate that a large number of adults attending Winnipeg Health Sciences Centre CF Clinic have serum 25-OHD levels below 30 ng/ml (75 nmol/L). This supports the need for dedicated and individualized approach to manage this condition. High dose therapy of vitamin D3, although a more aggressive treatment approach, may result in achieving optimal levels of serum 25-OHD in adults with CF. SN - 2405-4577 UR - https://www.unboundmedicine.com/medline/citation/29460819/Effect_of_high_dose_vitamin_D3_therapy_on_serum_vitamin_D3_levels_in_vitamin_D_insufficient_adults_with_cystic_fibrosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2405-4577(17)30367-4 DB - PRIME DP - Unbound Medicine ER -