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Moderate influenza vaccine effectiveness against influenza A(H1N1)pdm09 virus and low effectiveness against A(H3N2) virus among older adults during 2013-2014 influenza season in Beijing, China.
Hum Vaccin Immunother. 2018 06 03; 14(6):1323-1330.HV

Abstract

BACKGROUND

Since 2007, trivalent inactivated influenza vaccine has been provided free-of-charge to older adults aged ≥60 years in Beijing, China, but the data regarding influenza vaccine effectiveness (VE) among these people are very limited so far. We sought to estimate influenza VE against medically-attended laboratory-confirmed influenza illness among older adults during the 2013-2014 season.

METHODS

The influenza-like illness (ILI) patients aged 60 years and older who participated in the influenza virological surveillance of Beijing during 2013-2014 influenza season were recruited in this study. A test-negative design was employed to estimate influenza VE among older adults by using logistic regression models. VE was estimated using logistic regression, adjusted for sex, age, interval (days) between illness onset and specimen collection, and week of illness onset.

RESULTS

Between 1 November, 2013 and 30 April, 2014, a total of 487 elderly ILI patients were enrolled in the study, including 133 influenza-positive cases (of whom 6.8% were vaccinated) and 354 influenza-negative controls (of whom 10.2% were vaccinated). Among 133 influenza-positive cases, 51 tested positive for A(H1N1)pdm09 virus, 22 positive for A(H3N2) virus, 52 tested positive for B/Yamagata-lineage virus, 2 positive for B/Victoria-lineage virus, 1 positive for both A(H1N1)pdm09 and A(H3N2) viruses, and 5 tested positive for viruses of unknown subtype or lineage. The adjusted overall VE was estimated as 32% (95% CI:-48-69), with 59% (95% CI: -79-90) against A(H1N1)pdm09, 22% (95% CI: -253-83) against A(H3N2) and -20% (95% CI: -239-58) against B/Yamagata-lineage viruses.

CONCLUSIONS

These results suggested a modest protective effect of the 2013-2014 influenza vaccine among older adults in Beijing which was not statistically significant, with higher VE against the A(H1N1)pdm09 viruses compared to A(H3N2) and B viruses.

Authors+Show Affiliations

a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China. c School of Public Health, Capital Medical University , Beijing , China.a Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29461909

Citation

Zhang, Li, et al. "Moderate Influenza Vaccine Effectiveness Against Influenza A(H1N1)pdm09 Virus and Low Effectiveness Against A(H3N2) Virus Among Older Adults During 2013-2014 Influenza Season in Beijing, China." Human Vaccines & Immunotherapeutics, vol. 14, no. 6, 2018, pp. 1323-1330.
Zhang L, Pan Y, Ma C, et al. Moderate influenza vaccine effectiveness against influenza A(H1N1)pdm09 virus and low effectiveness against A(H3N2) virus among older adults during 2013-2014 influenza season in Beijing, China. Hum Vaccin Immunother. 2018;14(6):1323-1330.
Zhang, L., Pan, Y., Ma, C., Duan, W., Sun, Y., Wu, S., Zhang, M., Tian, Y., Zheng, Y., Yang, P., & Wang, Q. (2018). Moderate influenza vaccine effectiveness against influenza A(H1N1)pdm09 virus and low effectiveness against A(H3N2) virus among older adults during 2013-2014 influenza season in Beijing, China. Human Vaccines & Immunotherapeutics, 14(6), 1323-1330. https://doi.org/10.1080/21645515.2018.1441655
Zhang L, et al. Moderate Influenza Vaccine Effectiveness Against Influenza A(H1N1)pdm09 Virus and Low Effectiveness Against A(H3N2) Virus Among Older Adults During 2013-2014 Influenza Season in Beijing, China. Hum Vaccin Immunother. 2018 06 3;14(6):1323-1330. PubMed PMID: 29461909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate influenza vaccine effectiveness against influenza A(H1N1)pdm09 virus and low effectiveness against A(H3N2) virus among older adults during 2013-2014 influenza season in Beijing, China. AU - Zhang,Li, AU - Pan,Yang, AU - Ma,Chunna, AU - Duan,Wei, AU - Sun,Ying, AU - Wu,Shuangsheng, AU - Zhang,Man, AU - Tian,Yi, AU - Zheng,Yang, AU - Yang,Peng, AU - Wang,Quanyi, Y1 - 2018/04/11/ PY - 2018/2/21/pubmed PY - 2019/1/29/medline PY - 2018/2/21/entrez KW - China KW - effectiveness KW - elderly KW - influenza KW - test-negative design KW - vaccination SP - 1323 EP - 1330 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 14 IS - 6 N2 - BACKGROUND: Since 2007, trivalent inactivated influenza vaccine has been provided free-of-charge to older adults aged ≥60 years in Beijing, China, but the data regarding influenza vaccine effectiveness (VE) among these people are very limited so far. We sought to estimate influenza VE against medically-attended laboratory-confirmed influenza illness among older adults during the 2013-2014 season. METHODS: The influenza-like illness (ILI) patients aged 60 years and older who participated in the influenza virological surveillance of Beijing during 2013-2014 influenza season were recruited in this study. A test-negative design was employed to estimate influenza VE among older adults by using logistic regression models. VE was estimated using logistic regression, adjusted for sex, age, interval (days) between illness onset and specimen collection, and week of illness onset. RESULTS: Between 1 November, 2013 and 30 April, 2014, a total of 487 elderly ILI patients were enrolled in the study, including 133 influenza-positive cases (of whom 6.8% were vaccinated) and 354 influenza-negative controls (of whom 10.2% were vaccinated). Among 133 influenza-positive cases, 51 tested positive for A(H1N1)pdm09 virus, 22 positive for A(H3N2) virus, 52 tested positive for B/Yamagata-lineage virus, 2 positive for B/Victoria-lineage virus, 1 positive for both A(H1N1)pdm09 and A(H3N2) viruses, and 5 tested positive for viruses of unknown subtype or lineage. The adjusted overall VE was estimated as 32% (95% CI:-48-69), with 59% (95% CI: -79-90) against A(H1N1)pdm09, 22% (95% CI: -253-83) against A(H3N2) and -20% (95% CI: -239-58) against B/Yamagata-lineage viruses. CONCLUSIONS: These results suggested a modest protective effect of the 2013-2014 influenza vaccine among older adults in Beijing which was not statistically significant, with higher VE against the A(H1N1)pdm09 viruses compared to A(H3N2) and B viruses. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/29461909/Moderate_influenza_vaccine_effectiveness_against_influenza_A_H1N1_pdm09_virus_and_low_effectiveness_against_A_H3N2__virus_among_older_adults_during_2013_2014_influenza_season_in_Beijing_China_ L2 - https://www.tandfonline.com/doi/full/10.1080/21645515.2018.1441655 DB - PRIME DP - Unbound Medicine ER -