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Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study.
Inflamm Bowel Dis 2018; 24(3):633-640IB

Abstract

Background

A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC).

Methods

Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified. Each case was matched with2 controls by center, gender, age, date of recruitment, and follow-up time. At cohort entry, blood samples were collected and dietary vitamin D intakes were obtained from validated food frequency questionnaires. Serum 25-hydroxyvitamin D levels were measured using liquid chromatography-tandem mass spectrometry. Conditional logistic regression was performed to determine the odds of CD and UC.

Results

Seventy-two participants developed CD and 169 participants developed UC after a median follow-up of 4.7 and 4.1 years, respectively. Compared with the lowest quartile, no associations with the 3 higher quartiles of vitamin D concentrations were observed for CD (p trend = 0.34) or UC (p trend = 0.66). Similarly, no associations were detected when serum vitamin D levels were analyzed as a continuous variable. Dietary vitamin D intakes were not associated with CD (p trend = 0.39) or UC (p trend = 0.83).

Conclusions

Vitamin D status was not associated with the development of CD or UC. This does not suggest a major role for vitamin D deficiency in the etiology of IBD, although larger studies are needed to confirm these findings.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands.Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, United Kingdom. Department of Gastroenterology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom.Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, United Kingdom. Department of Gastroenterology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom.Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands.Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, the Netherlands.Department of Clinical Chemistry and Hematology, University Medical Center, Utrecht, the Netherlands.Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy.Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy.Center for Research in Epidemiology and Population Health, French Institute of Health and Medical Research (Inserm), Institut Gustave Roussy, Villejuif, France. Department of Gastroenterology, University Hospital of Bicêtre, Assistance Publique - Hôpitaux de Paris, Université Paris-Sud, Le Kremlin Bicêtre, France.Center for Research in Epidemiology and Population Health, French Institute of Health and Medical Research (Inserm), Institut Gustave Roussy, Villejuif, France. Department of Gastroenterology, University Hospital of Bicêtre, Assistance Publique - Hôpitaux de Paris, Université Paris-Sud, Le Kremlin Bicêtre, France.Center for Research in Epidemiology and Population Health, French Institute of Health and Medical Research (Inserm), Institut Gustave Roussy, Villejuif, France.Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.Institute of Regional Research-Center Sønderjylland, University of Southern Denmark, Odense, Denmark.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.Cancer Registry and Histopathology Unit, "Civic-M.P. Arezzo" Hospital, Ragusa, Italy.Hellenic Health Foundation, Athens, Greece.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.Department of Gastroenterology and Hepatology, Gelderse Vallei Hospital, Ede, the Netherlands. Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands.Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29462382

Citation

Opstelten, Jorrit L., et al. "Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: a Nested Case-Control Study." Inflammatory Bowel Diseases, vol. 24, no. 3, 2018, pp. 633-640.
Opstelten JL, Chan SSM, Hart AR, et al. Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study. Inflamm Bowel Dis. 2018;24(3):633-640.
Opstelten, J. L., Chan, S. S. M., Hart, A. R., van Schaik, F. D. M., Siersema, P. D., Lentjes, E. G. W. M., ... Oldenburg, B. (2018). Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study. Inflammatory Bowel Diseases, 24(3), pp. 633-640. doi:10.1093/ibd/izx050.
Opstelten JL, et al. Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: a Nested Case-Control Study. Inflamm Bowel Dis. 2018 02 15;24(3):633-640. PubMed PMID: 29462382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study. AU - Opstelten,Jorrit L, AU - Chan,Simon S M, AU - Hart,Andrew R, AU - van Schaik,Fiona D M, AU - Siersema,Peter D, AU - Lentjes,Eef G W M, AU - Khaw,Kay-Tee, AU - Luben,Robert, AU - Key,Timothy J, AU - Boeing,Heiner, AU - Bergmann,Manuela M, AU - Overvad,Kim, AU - Palli,Domenico, AU - Masala,Giovanna, AU - Racine,Antoine, AU - Carbonnel,Franck, AU - Boutron-Ruault,Marie-Christine, AU - Tjønneland,Anne, AU - Olsen,Anja, AU - Andersen,Vibeke, AU - Kaaks,Rudolf, AU - Kühn,Tilman, AU - Tumino,Rosario, AU - Trichopoulou,Antonia, AU - Peeters,Petra H M, AU - Verschuren,W M Monique, AU - Witteman,Ben J M, AU - Oldenburg,Bas, PY - 2017/06/10/received PY - 2018/2/21/entrez PY - 2018/2/21/pubmed PY - 2019/5/10/medline SP - 633 EP - 640 JF - Inflammatory bowel diseases JO - Inflamm. Bowel Dis. VL - 24 IS - 3 N2 - Background: A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods: Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified. Each case was matched with2 controls by center, gender, age, date of recruitment, and follow-up time. At cohort entry, blood samples were collected and dietary vitamin D intakes were obtained from validated food frequency questionnaires. Serum 25-hydroxyvitamin D levels were measured using liquid chromatography-tandem mass spectrometry. Conditional logistic regression was performed to determine the odds of CD and UC. Results: Seventy-two participants developed CD and 169 participants developed UC after a median follow-up of 4.7 and 4.1 years, respectively. Compared with the lowest quartile, no associations with the 3 higher quartiles of vitamin D concentrations were observed for CD (p trend = 0.34) or UC (p trend = 0.66). Similarly, no associations were detected when serum vitamin D levels were analyzed as a continuous variable. Dietary vitamin D intakes were not associated with CD (p trend = 0.39) or UC (p trend = 0.83). Conclusions: Vitamin D status was not associated with the development of CD or UC. This does not suggest a major role for vitamin D deficiency in the etiology of IBD, although larger studies are needed to confirm these findings. SN - 1536-4844 UR - https://www.unboundmedicine.com/medline/citation/29462382/Prediagnostic_Serum_Vitamin_D_Levels_and_the_Risk_of_Crohn's_Disease_and_Ulcerative_Colitis_in_European_Populations:_A_Nested_Case_Control_Study_ L2 - https://academic.oup.com/ibdjournal/article-lookup/doi/10.1093/ibd/izx050 DB - PRIME DP - Unbound Medicine ER -