TY - JOUR T1 - Business travel-associated illness: a GeoSentinel analysis. AU - Chen,Lin H, AU - Leder,Karin, AU - Barbre,Kira A, AU - Schlagenhauf,Patricia, AU - Libman,Michael, AU - Keystone,Jay, AU - Mendelson,Marc, AU - Gautret,Philippe, AU - Schwartz,Eli, AU - Shaw,Marc, AU - MacDonald,Sue, AU - McCarthy,Anne, AU - Connor,Bradley A, AU - Esposito,Douglas H, AU - Hamer,Davidson, AU - Wilson,Mary E, AU - ,, AU - Sonnenburg,Frank V, AU - Rothe,Camilla, AU - Kain,Kevin, AU - Boggild,Andrea, AU - Cramer,Jakob, AU - Jordan,Sabine, AU - Vinnemeier,Christof, AU - Yansouni,Cedric, AU - Chappuis,Francois, AU - Caumes,Eric, AU - Perignon,Alice, AU - Torresi,Joe, AU - Kanagawa,Shuzo, AU - Kato,Yasuyuki, AU - Grobusch,Martin, AU - Goorhuis,Bram, AU - Javelle,Emilie, AU - Kozarsky,Phyllis, AU - Wu,Henry, AU - Yoshimura,Yukiriro, AU - Tachikawa,Natsuo, AU - Lim,Poh-Lian, AU - Piyaphanee,Watcharapong, AU - Silachamroon,Udomsak, AU - Murphy,Holly, AU - Pandey,Prativa, AU - Ásgeirsson,Hilmir, AU - Glans,Hedvig, AU - Jensenius,Mogens, AU - Borwein,Sarah, AU - Hale,Devon, AU - Leung,Daniel, AU - Benson,Scott, AU - Genderen,Perry V, AU - Hynes,Noreen, AU - Weber,Rainer, AU - Stauffer,William, AU - Walker,Pat, AU - Haulman,Jean, AU - Roesel,David, AU - Mockenhaupt,Frank, AU - Harms-Zwingenberger,Gundel, AU - Rapp,Christoph, AU - Ficko,Cecile, AU - Vincent,Peter, AU - Castelli,Francesco, AU - Matteelli,Alberto, AU - Anderson,Susan, AU - Yates,Johnnie, AU - Licitra,Carmelo, AU - Klochko,Alena, AU - Gkrania-Klotsas,Effrossyni, AU - Warne,Ben, AU - Lopez-Velez,Rogelio, AU - Norman,Francesca, AU - Vincelette,Jean, AU - Barkati,Sapha, AU - Cahill,John, AU - McKinley,George, AU - Hoang Phu,Phi T, AU - Perez,Cecilia P, AU - Lalloo,David, AU - Beeching,Nicholas, AU - Coyle,Christina, AU - Hajek,Jan, AU - Ghesquiere,Wayne, AU - Siu,Hugo, AU - Valdez,Luis M, AU - Kelly,Paul, AU - Hagmann,Stefan, AU - Barnett,Elizabeth, AU - Hochberg,Natasha, AU - Malvy,Denis, AU - Duvignaud,Alexandre, AU - Kuhn,Susan, PY - 2017/06/21/received PY - 2018/01/02/accepted PY - 2018/2/21/entrez PY - 2018/2/21/pubmed PY - 2019/7/30/medline JF - Journal of travel medicine JO - J Travel Med VL - 25 IS - 1 N2 - Background: Analysis of a large cohort of business travelers will help clinicians focus on frequent and serious illnesses. We aimed to describe travel-related health problems in business travelers. Methods: GeoSentinel Surveillance Network consists of 64 travel and tropical medicine clinics in 29 countries; descriptive analysis was performed on ill business travelers, defined as persons traveling for work, evaluated after international travel 1 January 1997 through 31 December 2014. Results: Among 12 203 business travelers seen 1997-2014 (14 045 eligible diagnoses), the majority (97%) were adults aged 20-64 years; most (74%) reported from Western Europe or North America; two-thirds were male. Most (86%) were outpatients. Fewer than half (45%) reported a pre-travel healthcare encounter. Frequent regions of exposure were sub-Saharan Africa (37%), Southeast Asia (15%) and South Central Asia (14%). The most frequent diagnoses were malaria (9%), acute unspecified diarrhea (8%), viral syndrome (6%), acute bacterial diarrhea (5%) and chronic diarrhea (4%). Species was reported for 973 (90%) of 1079 patients with malaria, predominantly Plasmodium falciparum acquired in sub-Saharan Africa. Of 584 (54%) with malaria chemoprophylaxis information, 92% took none or incomplete courses. Thirteen deaths were reported, over half of which were due to malaria; others succumbed to pneumonia, typhoid fever, rabies, melioidosis and pyogenic abscess. Conclusions: Diarrheal illness was a major cause of morbidity. Malaria contributed substantial morbidity and mortality, particularly among business travelers to sub-Saharan Africa. Underuse or non-use of chemoprophylaxis contributed to malaria cases. Deaths in business travelers could be reduced by improving adherence to malaria chemoprophylaxis and targeted vaccination for vaccine-preventable diseases. Pre-travel advice is indicated for business travelers and is currently under-utilized and needs improvement. SN - 1708-8305 UR - https://www.unboundmedicine.com/medline/citation/29462444/Business_travel_associated_illness:_a_GeoSentinel_analysis_ L2 - https://academic.oup.com/jtm/article-lookup/doi/10.1093/jtm/tax097 DB - PRIME DP - Unbound Medicine ER -