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Business travel-associated illness: a GeoSentinel analysis.J Travel Med. 2018 01 01; 25(1)JT
Abstract
Background
Analysis of a large cohort of business travelers will help clinicians focus on frequent and serious illnesses. We aimed to describe travel-related health problems in business travelers.
Methods
GeoSentinel Surveillance Network consists of 64 travel and tropical medicine clinics in 29 countries; descriptive analysis was performed on ill business travelers, defined as persons traveling for work, evaluated after international travel 1 January 1997 through 31 December 2014.
Results
Among 12 203 business travelers seen 1997-2014 (14 045 eligible diagnoses), the majority (97%) were adults aged 20-64 years; most (74%) reported from Western Europe or North America; two-thirds were male. Most (86%) were outpatients. Fewer than half (45%) reported a pre-travel healthcare encounter. Frequent regions of exposure were sub-Saharan Africa (37%), Southeast Asia (15%) and South Central Asia (14%). The most frequent diagnoses were malaria (9%), acute unspecified diarrhea (8%), viral syndrome (6%), acute bacterial diarrhea (5%) and chronic diarrhea (4%). Species was reported for 973 (90%) of 1079 patients with malaria, predominantly Plasmodium falciparum acquired in sub-Saharan Africa. Of 584 (54%) with malaria chemoprophylaxis information, 92% took none or incomplete courses. Thirteen deaths were reported, over half of which were due to malaria; others succumbed to pneumonia, typhoid fever, rabies, melioidosis and pyogenic abscess.
Conclusions
Diarrheal illness was a major cause of morbidity. Malaria contributed substantial morbidity and mortality, particularly among business travelers to sub-Saharan Africa. Underuse or non-use of chemoprophylaxis contributed to malaria cases. Deaths in business travelers could be reduced by improving adherence to malaria chemoprophylaxis and targeted vaccination for vaccine-preventable diseases. Pre-travel advice is indicated for business travelers and is currently under-utilized and needs improvement.
Links
MeSH
Pub Type(s)
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Language
eng
PubMed ID
29462444
Citation
Chen, Lin H., et al. "Business Travel-associated Illness: a GeoSentinel Analysis." Journal of Travel Medicine, vol. 25, no. 1, 2018.
Chen LH, Leder K, Barbre KA, et al. Business travel-associated illness: a GeoSentinel analysis. J Travel Med. 2018;25(1).
Chen, L. H., Leder, K., Barbre, K. A., Schlagenhauf, P., Libman, M., Keystone, J., Mendelson, M., Gautret, P., Schwartz, E., Shaw, M., MacDonald, S., McCarthy, A., Connor, B. A., Esposito, D. H., Hamer, D., Wilson, M. E., Sonnenburg, F. V., Rothe, C., Kain, K., ... Kuhn, S. (2018). Business travel-associated illness: a GeoSentinel analysis. Journal of Travel Medicine, 25(1). https://doi.org/10.1093/jtm/tax097
Chen LH, et al. Business Travel-associated Illness: a GeoSentinel Analysis. J Travel Med. 2018 01 1;25(1) PubMed PMID: 29462444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Business travel-associated illness: a GeoSentinel analysis.
AU - Chen,Lin H,
AU - Leder,Karin,
AU - Barbre,Kira A,
AU - Schlagenhauf,Patricia,
AU - Libman,Michael,
AU - Keystone,Jay,
AU - Mendelson,Marc,
AU - Gautret,Philippe,
AU - Schwartz,Eli,
AU - Shaw,Marc,
AU - MacDonald,Sue,
AU - McCarthy,Anne,
AU - Connor,Bradley A,
AU - Esposito,Douglas H,
AU - Hamer,Davidson,
AU - Wilson,Mary E,
AU - ,,
AU - Sonnenburg,Frank V,
AU - Rothe,Camilla,
AU - Kain,Kevin,
AU - Boggild,Andrea,
AU - Cramer,Jakob,
AU - Jordan,Sabine,
AU - Vinnemeier,Christof,
AU - Yansouni,Cedric,
AU - Chappuis,Francois,
AU - Caumes,Eric,
AU - Perignon,Alice,
AU - Torresi,Joe,
AU - Kanagawa,Shuzo,
AU - Kato,Yasuyuki,
AU - Grobusch,Martin,
AU - Goorhuis,Bram,
AU - Javelle,Emilie,
AU - Kozarsky,Phyllis,
AU - Wu,Henry,
AU - Yoshimura,Yukiriro,
AU - Tachikawa,Natsuo,
AU - Lim,Poh-Lian,
AU - Piyaphanee,Watcharapong,
AU - Silachamroon,Udomsak,
AU - Murphy,Holly,
AU - Pandey,Prativa,
AU - Ásgeirsson,Hilmir,
AU - Glans,Hedvig,
AU - Jensenius,Mogens,
AU - Borwein,Sarah,
AU - Hale,Devon,
AU - Leung,Daniel,
AU - Benson,Scott,
AU - Genderen,Perry V,
AU - Hynes,Noreen,
AU - Weber,Rainer,
AU - Stauffer,William,
AU - Walker,Pat,
AU - Haulman,Jean,
AU - Roesel,David,
AU - Mockenhaupt,Frank,
AU - Harms-Zwingenberger,Gundel,
AU - Rapp,Christoph,
AU - Ficko,Cecile,
AU - Vincent,Peter,
AU - Castelli,Francesco,
AU - Matteelli,Alberto,
AU - Anderson,Susan,
AU - Yates,Johnnie,
AU - Licitra,Carmelo,
AU - Klochko,Alena,
AU - Gkrania-Klotsas,Effrossyni,
AU - Warne,Ben,
AU - Lopez-Velez,Rogelio,
AU - Norman,Francesca,
AU - Vincelette,Jean,
AU - Barkati,Sapha,
AU - Cahill,John,
AU - McKinley,George,
AU - Hoang Phu,Phi T,
AU - Perez,Cecilia P,
AU - Lalloo,David,
AU - Beeching,Nicholas,
AU - Coyle,Christina,
AU - Hajek,Jan,
AU - Ghesquiere,Wayne,
AU - Siu,Hugo,
AU - Valdez,Luis M,
AU - Kelly,Paul,
AU - Hagmann,Stefan,
AU - Barnett,Elizabeth,
AU - Hochberg,Natasha,
AU - Malvy,Denis,
AU - Duvignaud,Alexandre,
AU - Kuhn,Susan,
PY - 2017/06/21/received
PY - 2018/01/02/accepted
PY - 2018/2/21/entrez
PY - 2018/2/21/pubmed
PY - 2019/7/30/medline
JF - Journal of travel medicine
JO - J Travel Med
VL - 25
IS - 1
N2 - Background: Analysis of a large cohort of business travelers will help clinicians focus on frequent and serious illnesses. We aimed to describe travel-related health problems in business travelers. Methods: GeoSentinel Surveillance Network consists of 64 travel and tropical medicine clinics in 29 countries; descriptive analysis was performed on ill business travelers, defined as persons traveling for work, evaluated after international travel 1 January 1997 through 31 December 2014. Results: Among 12 203 business travelers seen 1997-2014 (14 045 eligible diagnoses), the majority (97%) were adults aged 20-64 years; most (74%) reported from Western Europe or North America; two-thirds were male. Most (86%) were outpatients. Fewer than half (45%) reported a pre-travel healthcare encounter. Frequent regions of exposure were sub-Saharan Africa (37%), Southeast Asia (15%) and South Central Asia (14%). The most frequent diagnoses were malaria (9%), acute unspecified diarrhea (8%), viral syndrome (6%), acute bacterial diarrhea (5%) and chronic diarrhea (4%). Species was reported for 973 (90%) of 1079 patients with malaria, predominantly Plasmodium falciparum acquired in sub-Saharan Africa. Of 584 (54%) with malaria chemoprophylaxis information, 92% took none or incomplete courses. Thirteen deaths were reported, over half of which were due to malaria; others succumbed to pneumonia, typhoid fever, rabies, melioidosis and pyogenic abscess. Conclusions: Diarrheal illness was a major cause of morbidity. Malaria contributed substantial morbidity and mortality, particularly among business travelers to sub-Saharan Africa. Underuse or non-use of chemoprophylaxis contributed to malaria cases. Deaths in business travelers could be reduced by improving adherence to malaria chemoprophylaxis and targeted vaccination for vaccine-preventable diseases. Pre-travel advice is indicated for business travelers and is currently under-utilized and needs improvement.
SN - 1708-8305
UR - https://www.unboundmedicine.com/medline/citation/29462444/Business_travel_associated_illness:_a_GeoSentinel_analysis_
L2 - https://academic.oup.com/jtm/article-lookup/doi/10.1093/jtm/tax097
DB - PRIME
DP - Unbound Medicine
ER -
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