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Exciton-Plasmon Interaction between AuNPs/Graphene Nanohybrids and CdS Quantum Dots/TiO2 for Photoelectrochemical Aptasensing of Prostate-Specific Antigen.
ACS Sens. 2018 03 23; 3(3):632-639.AS

Abstract

A competitive-displacement reaction strategy based on target-induced dissociation of gold nanoparticle coated graphene nanosheet (AuNPs/GN) from CdS quantum dot functionalized mesoporous titanium dioxide (CdS QDs/TiO2) was designed for the sensitive photoelectrochemical (PEC) aptasensing of prostate-specific antigen (PSA) through the exciton-plasmon interaction (EPI) between CdS QDs and AuNPs. To construct such an aptasensing system, capture DNA was initially conjugated covalently onto CdS QDs/TiO2-modified electrode, and then AuNPs/GN-labeled PSA aptamer was bound onto biofunctionalized CdS QDs/TiO2 via hybridization chain reaction of partial bases with capture DNA. Introduction of AuNPs/GN efficiently quenched the photocurrent of CdS QDs/TiO2 thanks to energy transfer. Upon addition of target PSA, the sandwiched aptamer between CdS QDs/TiO2 and AuNPs/GN reacted with the analyte analyte, thus resulting in the dissociation of AuNPs/GN from the CdS QDs/TiO2 to increase the photocurrent. Under optimum conditions, the aptasensing platform exhibited a high sensitivity for PSA detection within a dynamic linear range of 1.0 pg/mL to 8.0 ng/mL at a low limitat of detection of 0.52 pg/mL. The interparticle distance of exciton-plasmon interaction and contents of AuNPs corresponding to EPI effect in this system were also studied. Good selectivity and high reproducibility were obtained for the analysis of target PSA. Importantly, the accuracy and matrix effect of PEC aptasensor was evaluated for the determination of human serum specimens and newborn calf serum-diluted PSA standards, giving a well-matched result with the referenced PSA ELISA kit.

Authors+Show Affiliations

Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry , Fuzhou University , Fuzhou 35011168 , People's Republic of China.Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry , Fuzhou University , Fuzhou 35011168 , People's Republic of China.Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry , Fuzhou University , Fuzhou 35011168 , People's Republic of China.Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry , Fuzhou University , Fuzhou 35011168 , People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29465232

Citation

Cai, Guoneng, et al. "Exciton-Plasmon Interaction Between AuNPs/Graphene Nanohybrids and CdS Quantum Dots/TiO2 for Photoelectrochemical Aptasensing of Prostate-Specific Antigen." ACS Sensors, vol. 3, no. 3, 2018, pp. 632-639.
Cai G, Yu Z, Ren R, et al. Exciton-Plasmon Interaction between AuNPs/Graphene Nanohybrids and CdS Quantum Dots/TiO2 for Photoelectrochemical Aptasensing of Prostate-Specific Antigen. ACS Sens. 2018;3(3):632-639.
Cai, G., Yu, Z., Ren, R., & Tang, D. (2018). Exciton-Plasmon Interaction between AuNPs/Graphene Nanohybrids and CdS Quantum Dots/TiO2 for Photoelectrochemical Aptasensing of Prostate-Specific Antigen. ACS Sensors, 3(3), 632-639. https://doi.org/10.1021/acssensors.7b00899
Cai G, et al. Exciton-Plasmon Interaction Between AuNPs/Graphene Nanohybrids and CdS Quantum Dots/TiO2 for Photoelectrochemical Aptasensing of Prostate-Specific Antigen. ACS Sens. 2018 03 23;3(3):632-639. PubMed PMID: 29465232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exciton-Plasmon Interaction between AuNPs/Graphene Nanohybrids and CdS Quantum Dots/TiO2 for Photoelectrochemical Aptasensing of Prostate-Specific Antigen. AU - Cai,Guoneng, AU - Yu,Zhengzhong, AU - Ren,Rongrong, AU - Tang,Dianping, Y1 - 2018/02/23/ PY - 2018/2/22/pubmed PY - 2019/7/23/medline PY - 2018/2/22/entrez KW - CdS quantum dot coated mesoporous TiO2 KW - competitive-displacement reaction KW - exciton−plasmon interaction KW - nanogold-functionalized graphene nanosheets KW - photoelectrochemical aptasensor SP - 632 EP - 639 JF - ACS sensors JO - ACS Sens VL - 3 IS - 3 N2 - A competitive-displacement reaction strategy based on target-induced dissociation of gold nanoparticle coated graphene nanosheet (AuNPs/GN) from CdS quantum dot functionalized mesoporous titanium dioxide (CdS QDs/TiO2) was designed for the sensitive photoelectrochemical (PEC) aptasensing of prostate-specific antigen (PSA) through the exciton-plasmon interaction (EPI) between CdS QDs and AuNPs. To construct such an aptasensing system, capture DNA was initially conjugated covalently onto CdS QDs/TiO2-modified electrode, and then AuNPs/GN-labeled PSA aptamer was bound onto biofunctionalized CdS QDs/TiO2 via hybridization chain reaction of partial bases with capture DNA. Introduction of AuNPs/GN efficiently quenched the photocurrent of CdS QDs/TiO2 thanks to energy transfer. Upon addition of target PSA, the sandwiched aptamer between CdS QDs/TiO2 and AuNPs/GN reacted with the analyte analyte, thus resulting in the dissociation of AuNPs/GN from the CdS QDs/TiO2 to increase the photocurrent. Under optimum conditions, the aptasensing platform exhibited a high sensitivity for PSA detection within a dynamic linear range of 1.0 pg/mL to 8.0 ng/mL at a low limitat of detection of 0.52 pg/mL. The interparticle distance of exciton-plasmon interaction and contents of AuNPs corresponding to EPI effect in this system were also studied. Good selectivity and high reproducibility were obtained for the analysis of target PSA. Importantly, the accuracy and matrix effect of PEC aptasensor was evaluated for the determination of human serum specimens and newborn calf serum-diluted PSA standards, giving a well-matched result with the referenced PSA ELISA kit. SN - 2379-3694 UR - https://www.unboundmedicine.com/medline/citation/29465232/Exciton_Plasmon_Interaction_between_AuNPs/Graphene_Nanohybrids_and_CdS_Quantum_Dots/TiO2_for_Photoelectrochemical_Aptasensing_of_Prostate_Specific_Antigen_ L2 - https://medlineplus.gov/prostatecancerscreening.html DB - PRIME DP - Unbound Medicine ER -