Tags

Type your tag names separated by a space and hit enter

Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis.
Muscle Nerve. 2018 Aug; 58(2):261-269.MN

Abstract

INTRODUCTION

Amyotrophic lateral sclerosis (ALS) is a debilitating neurologic disorder with poor survival rates and no clear biomarkers for disease diagnosis and prognosis.

METHODS

We compared serum microRNA (miRNA) expression from patients with ALS with healthy controls and patients with multiple sclerosis and Alzheimer disease. We also correlated miRNA expression in cross-sectional and longitudinal cohorts of ALS patients with clinical parameters.

RESULTS

We identified 7 miRNAs (miR-192-5p, miR-192-3p, miR-1, miR-133a-3p, miR-133b, miR-144-5p, miR-19a-3p) that were upregulated and 6 miRNAs (miR-320c, miR-320a, let-7d-3p, miR-425-5p, miR-320b, miR-139-5p) that were downregulated in patients with ALS compared with healthy controls, patients with Alzheimer disease, and patients with multiple sclerosis. Changes in 4 miRNAs (miR-136-3p, miR-30b-5p, miR-331-3p, miR-496) correlated positively and change in 1 miRNA (miR-2110) correlated negatively with changes in clinical parameters in longitudinal analysis.

DISCUSSION

Our findings identified serum miRNAs that can serve as biomarkers for ALS diagnosis and progression. Muscle Nerve 58: 261-269, 2018.

Links

Authors+Show Affiliations

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

MeSH

AdultAlzheimer DiseaseAmyotrophic Lateral SclerosisBiomarkersCohort StudiesCross-Sectional StudiesDisease ProgressionFemaleGene Expression RegulationHumansLongitudinal StudiesMaleMicroRNAsMiddle AgedMultiple Sclerosis

Pub Type(s)

Journal Article

Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29466830

Citation

Raheja, Radhika, et al. "Correlating Serum Micrornas and Clinical Parameters in Amyotrophic Lateral Sclerosis." Muscle & Nerve, vol. 58, no. 2, 2018, pp. 261-269.

Raheja R, Regev K, Healy BC, et al. Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis. Muscle Nerve. 2018;58(2):261-269.

Raheja, R., Regev, K., Healy, B. C., Mazzola, M. A., Beynon, V., Von Glehn, F., Paul, A., Diaz-Cruz, C., Gholipour, T., Glanz, B. I., Kivisakk, P., Chitnis, T., Weiner, H. L., Berry, J. D., & Gandhi, R. (2018). Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis. Muscle & Nerve, 58(2), 261-269. https://doi.org/10.1002/mus.26106

Raheja R, et al. Correlating Serum Micrornas and Clinical Parameters in Amyotrophic Lateral Sclerosis. Muscle Nerve. 2018;58(2):261-269. PubMed PMID: 29466830.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis. AU - Raheja,Radhika, AU - Regev,Keren, AU - Healy,Brian C, AU - Mazzola,Maria Antonietta, AU - Beynon,Vanessa, AU - Von Glehn,Felipe, AU - Paul,Anu, AU - Diaz-Cruz,Camilo, AU - Gholipour,Taha, AU - Glanz,Bonnie I, AU - Kivisakk,Pia, AU - Chitnis,Tanuja, AU - Weiner,Howard L, AU - Berry,James D, AU - Gandhi,Roopali, Y1 - 2018/03/25/ PY - 2017/07/24/received PY - 2018/02/12/revised PY - 2018/02/17/accepted PY - 2018/2/22/pubmed PY - 2019/4/23/medline PY - 2018/2/22/entrez KW - ALS KW - biomarkers KW - disease comparisons KW - longitudinal analysis KW - microRNA KW - serum SP - 261 EP - 269 JF - Muscle & nerve JO - Muscle Nerve VL - 58 IS - 2 N2 - INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a debilitating neurologic disorder with poor survival rates and no clear biomarkers for disease diagnosis and prognosis. METHODS: We compared serum microRNA (miRNA) expression from patients with ALS with healthy controls and patients with multiple sclerosis and Alzheimer disease. We also correlated miRNA expression in cross-sectional and longitudinal cohorts of ALS patients with clinical parameters. RESULTS: We identified 7 miRNAs (miR-192-5p, miR-192-3p, miR-1, miR-133a-3p, miR-133b, miR-144-5p, miR-19a-3p) that were upregulated and 6 miRNAs (miR-320c, miR-320a, let-7d-3p, miR-425-5p, miR-320b, miR-139-5p) that were downregulated in patients with ALS compared with healthy controls, patients with Alzheimer disease, and patients with multiple sclerosis. Changes in 4 miRNAs (miR-136-3p, miR-30b-5p, miR-331-3p, miR-496) correlated positively and change in 1 miRNA (miR-2110) correlated negatively with changes in clinical parameters in longitudinal analysis. DISCUSSION: Our findings identified serum miRNAs that can serve as biomarkers for ALS diagnosis and progression. Muscle Nerve 58: 261-269, 2018. SN - 1097-4598 UR - https://www.unboundmedicine.com/medline/citation/29466830/Correlating_serum_micrornas_and_clinical_parameters_in_amyotrophic_lateral_sclerosis_ DB - PRIME DP - Unbound Medicine ER -