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[Studies on resistance of Schistosoma to praziquantel XⅥ Biological characteristics of praziquantel-resistant isolates of Schistomoma japonicum in Oncomelania hupensis snails].

Abstract

OBJECTIVE

To investigate the difference of biological characteristics between the praziquantel-resistant and -susceptible isolates of Schistosoma japonicum in intermediate host Oncomelania hupensis snails.

METHODS

Mice were infected with cercariae of praziquantel-resistant and -susceptible isolates of S. japonicum, and the parasite eggs were collected 37 days post-infection to hatch miracidium. Then, the snails were infected with the miracidium of each parasite isolate. The snail infection, survival rate of infected snails, prepatent period of cercariae, and the total number of cercariae shed from each infected snail were observed and compared between the praziquantel-resistant and -susceptible isolates of S. japonicum.

RESULTS

If each snail was exposed to a single miracidium, there were significant differences between the praziquantel-resistant and -susceptible Jiangsu isolates in the snail infection (8.99% vs. 19.74%; χ2 = 3.948, P = 0.047) and the number of cercaria released from a single snail (1 460.2 vs. 1 039.3; t = 2.507, P = 0.02), and there were significant differences between the praziquantel-susceptible and -resistant Hunan isolates in the snail infection (10.00% vs. 21.52%; χ2 = 3.980, P = 0.046) and the number of cercaria released from a single snail (1 319.4 vs. 1 003.5; t = 2.566, P = 0.017). However, there were no significant differences between the praziquantel-resistant and -susceptible isolates of S. japonicum in the prepatent period of cercariae and the survival rate of infected snails (P > 0.05).

CONCLUSIONS

The praziquantel-resistant isolate of S. japonicum has a higher susceptibility to O. hupensis but less cercaria released from each infected snail than the susceptible isolate.

Authors+Show Affiliations

Key Laboratory of National Health and Family Planning Commission on Technology for Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center of Jiangnan University, Wuxi 214064, China. Nanchang Center for Disease Control and Prevention, Jiangxi Province, China.Key Laboratory of National Health and Family Planning Commission on Technology for Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center of Jiangnan University, Wuxi 214064, China.Key Laboratory of National Health and Family Planning Commission on Technology for Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center of Jiangnan University, Wuxi 214064, China.Key Laboratory of National Health and Family Planning Commission on Technology for Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center of Jiangnan University, Wuxi 214064, China.Key Laboratory of National Health and Family Planning Commission on Technology for Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center of Jiangnan University, Wuxi 214064, China.Key Laboratory of National Health and Family Planning Commission on Technology for Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center of Jiangnan University, Wuxi 214064, China.Key Laboratory of National Health and Family Planning Commission on Technology for Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center of Jiangnan University, Wuxi 214064, China.Key Laboratory of National Health and Family Planning Commission on Technology for Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center of Jiangnan University, Wuxi 214064, China.Key Laboratory of National Health and Family Planning Commission on Technology for Parasitic Disease Prevention and Control, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center of Jiangnan University, Wuxi 214064, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29469442

Citation

Ke, Qian, et al. "[Studies On Resistance of Schistosoma to Praziquantel XⅥ Biological Characteristics of Praziquantel-resistant Isolates of Schistomoma Japonicum in Oncomelania Hupensis Snails]." Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi = Chinese Journal of Schistosomiasis Control, vol. 29, no. 6, 2017, pp. 678-682.
Ke Q, You-Sheng L, Wei W, et al. [Studies on resistance of Schistosoma to praziquantel XⅥ Biological characteristics of praziquantel-resistant isolates of Schistomoma japonicum in Oncomelania hupensis snails]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2017;29(6):678-682.
Ke, Q., You-Sheng, L., Wei, W., Guo-Li, Q., Hong-Jun, L., Zhen-Kun, Y., ... Jian-Rong, D. (2017). [Studies on resistance of Schistosoma to praziquantel XⅥ Biological characteristics of praziquantel-resistant isolates of Schistomoma japonicum in Oncomelania hupensis snails]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi = Chinese Journal of Schistosomiasis Control, 29(6), pp. 678-682. doi:10.16250/j.32.1374.2017101.
Ke Q, et al. [Studies On Resistance of Schistosoma to Praziquantel XⅥ Biological Characteristics of Praziquantel-resistant Isolates of Schistomoma Japonicum in Oncomelania Hupensis Snails]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2017 Dec 26;29(6):678-682. PubMed PMID: 29469442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Studies on resistance of Schistosoma to praziquantel XⅥ Biological characteristics of praziquantel-resistant isolates of Schistomoma japonicum in Oncomelania hupensis snails]. AU - Ke,Qian, AU - You-Sheng,Liang, AU - Wei,Wang, AU - Guo-Li,Qu, AU - Hong-Jun,Li, AU - Zhen-Kun,Yang, AU - Zheng-Yang,Zhao, AU - Yuntian,Xing, AU - Jian-Rong,Dai, PY - 2018/2/23/entrez PY - 2018/2/23/pubmed PY - 2018/7/24/medline KW - Biological characteristics KW - Drug resistance KW - Oncomelania hupensis KW - Praziquantel KW - Schistosoma japonicum SP - 678 EP - 682 JF - Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control JO - Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi VL - 29 IS - 6 N2 - OBJECTIVE: To investigate the difference of biological characteristics between the praziquantel-resistant and -susceptible isolates of Schistosoma japonicum in intermediate host Oncomelania hupensis snails. METHODS: Mice were infected with cercariae of praziquantel-resistant and -susceptible isolates of S. japonicum, and the parasite eggs were collected 37 days post-infection to hatch miracidium. Then, the snails were infected with the miracidium of each parasite isolate. The snail infection, survival rate of infected snails, prepatent period of cercariae, and the total number of cercariae shed from each infected snail were observed and compared between the praziquantel-resistant and -susceptible isolates of S. japonicum. RESULTS: If each snail was exposed to a single miracidium, there were significant differences between the praziquantel-resistant and -susceptible Jiangsu isolates in the snail infection (8.99% vs. 19.74%; χ2 = 3.948, P = 0.047) and the number of cercaria released from a single snail (1 460.2 vs. 1 039.3; t = 2.507, P = 0.02), and there were significant differences between the praziquantel-susceptible and -resistant Hunan isolates in the snail infection (10.00% vs. 21.52%; χ2 = 3.980, P = 0.046) and the number of cercaria released from a single snail (1 319.4 vs. 1 003.5; t = 2.566, P = 0.017). However, there were no significant differences between the praziquantel-resistant and -susceptible isolates of S. japonicum in the prepatent period of cercariae and the survival rate of infected snails (P > 0.05). CONCLUSIONS: The praziquantel-resistant isolate of S. japonicum has a higher susceptibility to O. hupensis but less cercaria released from each infected snail than the susceptible isolate. SN - 1005-6661 UR - https://www.unboundmedicine.com/medline/citation/29469442/[Studies_on_resistance_of_Schistosoma_to_praziquantel_XⅥ_Biological_characteristics_of_praziquantel_resistant_isolates_of_Schistomoma_japonicum_in_Oncomelania_hupensis_snails]_ DB - PRIME DP - Unbound Medicine ER -