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[Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils].
Presse Med 1986; 15(31):1511-5PM

Abstract

Certain anatomical characteristics peculiar to the gerbil make it the animal model best adapted to experimental pathology studies of acute ischaemia. In this animal species, devoid of any substitute vertebro-basilar vascular tissue, unilateral ligature of the carotid artery produces a cerebral ischaemia with neurological signs (well quantifiable), metabolic perturbations (especially mitochondrial) and cerebral oedema development closely resembling the symptoms revealed by physiopathology in human clinical studies. Using this model and under the experimental conditions described, clear-cut, highly significant results were obtained with Ginkgo biloba, whether by oral or intravenous administration. These results were normalization of mitochondrial respiration, diminution of cerebral oedema, correction of the accompanying ionic perturbations, and practically total functional restoration revealed by a normal neurological index in the gerbils treated with Ginkgo biloba extract.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

fre

PubMed ID

2947090

Citation

Spinnewyn, B, et al. "[Effects of Ginkgo Biloba Extract On a Cerebral Ischemia Model in Gerbils]." Presse Medicale (Paris, France : 1983), vol. 15, no. 31, 1986, pp. 1511-5.
Spinnewyn B, Blavet N, Clostre F. [Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils]. Presse Med. 1986;15(31):1511-5.
Spinnewyn, B., Blavet, N., & Clostre, F. (1986). [Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils]. Presse Medicale (Paris, France : 1983), 15(31), pp. 1511-5.
Spinnewyn B, Blavet N, Clostre F. [Effects of Ginkgo Biloba Extract On a Cerebral Ischemia Model in Gerbils]. Presse Med. 1986 Sep 25;15(31):1511-5. PubMed PMID: 2947090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils]. AU - Spinnewyn,B, AU - Blavet,N, AU - Clostre,F, PY - 1986/9/25/pubmed PY - 1986/9/25/medline PY - 1986/9/25/entrez SP - 1511 EP - 5 JF - Presse medicale (Paris, France : 1983) JO - Presse Med VL - 15 IS - 31 N2 - Certain anatomical characteristics peculiar to the gerbil make it the animal model best adapted to experimental pathology studies of acute ischaemia. In this animal species, devoid of any substitute vertebro-basilar vascular tissue, unilateral ligature of the carotid artery produces a cerebral ischaemia with neurological signs (well quantifiable), metabolic perturbations (especially mitochondrial) and cerebral oedema development closely resembling the symptoms revealed by physiopathology in human clinical studies. Using this model and under the experimental conditions described, clear-cut, highly significant results were obtained with Ginkgo biloba, whether by oral or intravenous administration. These results were normalization of mitochondrial respiration, diminution of cerebral oedema, correction of the accompanying ionic perturbations, and practically total functional restoration revealed by a normal neurological index in the gerbils treated with Ginkgo biloba extract. SN - 0755-4982 UR - https://www.unboundmedicine.com/medline/citation/2947090/[Effects_of_Ginkgo_biloba_extract_on_a_cerebral_ischemia_model_in_gerbils]_ DB - PRIME DP - Unbound Medicine ER -