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Effectiveness of influenza vaccine in preventing medically-attended influenza virus infection in primary care, Israel, influenza seasons 2014/15 and 2015/16.
Euro Surveill. 2018 02; 23(7)ES

Abstract

IntroductionInfluenza vaccine is recommended for the entire population in Israel. We assessed influenza vaccine effectiveness (VE) for the 2014/15 and 2015/16 seasons in Israel, for the first time.

Methods:

Combined nose and throat swab specimens were collected from patients with influenza-like illness (ILI) presenting to sentinel primary care clinics and tested for influenza virus by RT-PCR. VE of the trivalent inactivated vaccine (TIV) was assessed using test-negative case-control design.

Results:

During the 2014/15 season 1,142 samples were collected; 327 (28.6%) were positive for influenza, 83.8% A(H3N2), 5.8% A(H1N1)pdm09, 9.2% B and 1.2% A un-subtyped. Adjusted VE against all influenza viruses for this influenza season was -4.8% (95% confidence interval (CI): -54.8 to 29.0) and against influenza A(H3N2), it was -15.8% (95% CI: -72.8 to 22.4). For the 2015/16 season, 1,919 samples were collected; 853 (44.4%) were positive for influenza, 43.5% A(H1N1)pdm09, 57% B, 0.7% A(H3N2) and 11 samples positive for both A(H1N1)pdm09 and B. Adjusted VE against all influenza viruses for this influenza season was 8.8% (95% CI: -25.1 to 33.5), against influenza A(H1N1)pdm09, it was 32.3% (95% CI: (-4.3 to 56.1) and against influenza B, it was -2.2% (95% CI: (-47.0 to 29.0).

Conclusions:

Using samples from patients with ILI visiting sentinel clinics in Israel, we demonstrated the feasibility of influenza VE estimation in Israel.

Authors+Show Affiliations

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine Tel Aviv University, Tel Aviv, Israel.Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan, Israel.Central Virology Laboratory, Israel Ministry of Health, Chaim Sheba Medical Center, Ramat Gan, Israel. Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan, Israel.Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan, Israel.School of Public Health, University of Michigan, Ann Arbor, Michigan, United States. Ben Gurion University, Beer Sheva, Israel.Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan, Israel.Central Virology Laboratory, Israel Ministry of Health, Chaim Sheba Medical Center, Ramat Gan, Israel. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine Tel Aviv University, Tel Aviv, Israel.Central Virology Laboratory, Israel Ministry of Health, Chaim Sheba Medical Center, Ramat Gan, Israel. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine Tel Aviv University, Tel Aviv, Israel.Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan, Israel. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine Tel Aviv University, Tel Aviv, Israel.Departments of Pediatrics and Family and Community Medicine, New York Medical College, Valhalla, New York, United States. Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan, Israel. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine Tel Aviv University, Tel Aviv, Israel.The members of the group are listed at the end of the paper.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29471622

Citation

Yaron-Yakoby, Hamutal, et al. "Effectiveness of Influenza Vaccine in Preventing Medically-attended Influenza Virus Infection in Primary Care, Israel, Influenza Seasons 2014/15 and 2015/16." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 23, no. 7, 2018.
Yaron-Yakoby H, Sefty H, Pando R, et al. Effectiveness of influenza vaccine in preventing medically-attended influenza virus infection in primary care, Israel, influenza seasons 2014/15 and 2015/16. Euro Surveill. 2018;23(7).
Yaron-Yakoby, H., Sefty, H., Pando, R., Dichtiar, R., Katz, M. A., Stein, Y., Mandelboim, M., Mendelson, E., Shohat, T., & Glatman-Freedman, A. (2018). Effectiveness of influenza vaccine in preventing medically-attended influenza virus infection in primary care, Israel, influenza seasons 2014/15 and 2015/16. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 23(7). https://doi.org/10.2807/1560-7917.ES.2018.23.7.17-00026
Yaron-Yakoby H, et al. Effectiveness of Influenza Vaccine in Preventing Medically-attended Influenza Virus Infection in Primary Care, Israel, Influenza Seasons 2014/15 and 2015/16. Euro Surveill. 2018;23(7) PubMed PMID: 29471622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of influenza vaccine in preventing medically-attended influenza virus infection in primary care, Israel, influenza seasons 2014/15 and 2015/16. AU - Yaron-Yakoby,Hamutal, AU - Sefty,Hanna, AU - Pando,Rakefet, AU - Dichtiar,Rita, AU - Katz,Mark A, AU - Stein,Yaniv, AU - Mandelboim,Michal, AU - Mendelson,Ella, AU - Shohat,Tamy, AU - Glatman-Freedman,Aharona, AU - ,, PY - 2018/2/24/entrez PY - 2018/2/24/pubmed PY - 2019/4/5/medline KW - ILI KW - immunisations KW - influenza KW - influenza-like illness KW - vaccines JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill VL - 23 IS - 7 N2 - IntroductionInfluenza vaccine is recommended for the entire population in Israel. We assessed influenza vaccine effectiveness (VE) for the 2014/15 and 2015/16 seasons in Israel, for the first time. Methods: Combined nose and throat swab specimens were collected from patients with influenza-like illness (ILI) presenting to sentinel primary care clinics and tested for influenza virus by RT-PCR. VE of the trivalent inactivated vaccine (TIV) was assessed using test-negative case-control design. Results: During the 2014/15 season 1,142 samples were collected; 327 (28.6%) were positive for influenza, 83.8% A(H3N2), 5.8% A(H1N1)pdm09, 9.2% B and 1.2% A un-subtyped. Adjusted VE against all influenza viruses for this influenza season was -4.8% (95% confidence interval (CI): -54.8 to 29.0) and against influenza A(H3N2), it was -15.8% (95% CI: -72.8 to 22.4). For the 2015/16 season, 1,919 samples were collected; 853 (44.4%) were positive for influenza, 43.5% A(H1N1)pdm09, 57% B, 0.7% A(H3N2) and 11 samples positive for both A(H1N1)pdm09 and B. Adjusted VE against all influenza viruses for this influenza season was 8.8% (95% CI: -25.1 to 33.5), against influenza A(H1N1)pdm09, it was 32.3% (95% CI: (-4.3 to 56.1) and against influenza B, it was -2.2% (95% CI: (-47.0 to 29.0). Conclusions: Using samples from patients with ILI visiting sentinel clinics in Israel, we demonstrated the feasibility of influenza VE estimation in Israel. SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/29471622/Effectiveness_of_influenza_vaccine_in_preventing_medically_attended_influenza_virus_infection_in_primary_care_Israel_influenza_seasons_2014/15_and_2015/16_ L2 - http://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2018.23.7.17-00026 DB - PRIME DP - Unbound Medicine ER -