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Contribution of non-traditional lipid profiles to reduced glomerular filtration rate in H-type hypertension population of rural China.
Ann Med. 2018 05; 50(3):249-259.AM

Abstract

BACKGROUND

Despite current interest in the unfavourable impact of non-traditional lipid profiles on cardiovascular disease, information regarding its relations to reduced glomerular filtration rate (GFR) in H-type hypertension population has not been systemically elucidated.

METHODS

Analyses were based upon a cross-sectional study of 3259 participants with H-type hypertension who underwent assessment of biochemical, anthropometric and blood pressure values. Reduced GFR was considered if meeting estimated GFR <60 ml/min/1.73 m2.

RESULTS

A stepwise multivariate regression analysis indicated that non-traditional lipid parameters remained as independent determinants of estimated GFR (all p < .001). In multivariable models, we observed a 50%, 51%, 31%, and 24% higher risk for decreased GFR with each SD increment in TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C levels, respectively. The highest quartile of TC/HDL-C, TG/HDL-C and LDL-C/HDL-C ratios carried reduced GFR odds (confidence intervals) of 5.50 (2.50 to 12.09), 6.63 (2.58 to 17.05) and 2.22 (1.15 to 4.29), respectively.

CONCLUSIONS

The relative independent contribution of non-traditional lipid profiles, as indexed by TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C, towards reduced GFR putting research evidence at the very heart of lipoprotein-mediated renal injury set a vital example for applying a clinical and public health recommendation for reducing the burden of chronic kidney disease. KEY MESSAGES Non-traditional lipid profiles has been linked with the occurrence of cardiovascular disease, but none of the studies that address the effect of non-traditional lipid profiles on reduced GFR risk in H-type hypertension population has been specifically established. A greater emphasis of this study resided in the intrinsic value of TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C that integrate atherogenic and anti-atherogenic lipid molecules to predict the risk of reduced GFR among H-type hypertension population and provide insight into the pathophysiology of subsequent cardio-cerebrovascular outcomes. In a large Chinese H-type hypertension adults, the relative independent contribution of non-traditional lipid profiles, as indexed by TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C, towards reduced GFR putting research evidence at the very heart of lipoprotein-mediated renal injury set a vital example for applying a clinical and public health recommendation for reducing the burden of CKD.

Authors+Show Affiliations

a Department of Cardiology , The First Hospital of China Medical University , Shenyang , Liaoning , People's Republic of China.a Department of Cardiology , The First Hospital of China Medical University , Shenyang , Liaoning , People's Republic of China.a Department of Cardiology , The First Hospital of China Medical University , Shenyang , Liaoning , People's Republic of China.a Department of Cardiology , The First Hospital of China Medical University , Shenyang , Liaoning , People's Republic of China.a Department of Cardiology , The First Hospital of China Medical University , Shenyang , Liaoning , People's Republic of China.a Department of Cardiology , The First Hospital of China Medical University , Shenyang , Liaoning , People's Republic of China.a Department of Cardiology , The First Hospital of China Medical University , Shenyang , Liaoning , People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29473759

Citation

Wang, Haoyu, et al. "Contribution of Non-traditional Lipid Profiles to Reduced Glomerular Filtration Rate in H-type Hypertension Population of Rural China." Annals of Medicine, vol. 50, no. 3, 2018, pp. 249-259.
Wang H, Li Z, Guo X, et al. Contribution of non-traditional lipid profiles to reduced glomerular filtration rate in H-type hypertension population of rural China. Ann Med. 2018;50(3):249-259.
Wang, H., Li, Z., Guo, X., Chen, Y., Chen, S., Tian, Y., & Sun, Y. (2018). Contribution of non-traditional lipid profiles to reduced glomerular filtration rate in H-type hypertension population of rural China. Annals of Medicine, 50(3), 249-259. https://doi.org/10.1080/07853890.2018.1445277
Wang H, et al. Contribution of Non-traditional Lipid Profiles to Reduced Glomerular Filtration Rate in H-type Hypertension Population of Rural China. Ann Med. 2018;50(3):249-259. PubMed PMID: 29473759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of non-traditional lipid profiles to reduced glomerular filtration rate in H-type hypertension population of rural China. AU - Wang,Haoyu, AU - Li,Zhao, AU - Guo,Xiaofan, AU - Chen,Yintao, AU - Chen,Shuang, AU - Tian,Yichen, AU - Sun,Yingxian, Y1 - 2018/02/28/ PY - 2018/2/24/pubmed PY - 2019/8/14/medline PY - 2018/2/24/entrez KW - H-type hypertension KW - Non-traditional lipid profiles KW - chronic kidney disease KW - epidemiology KW - glomerular filtration rate KW - lipid ratios KW - rural area SP - 249 EP - 259 JF - Annals of medicine JO - Ann Med VL - 50 IS - 3 N2 - BACKGROUND: Despite current interest in the unfavourable impact of non-traditional lipid profiles on cardiovascular disease, information regarding its relations to reduced glomerular filtration rate (GFR) in H-type hypertension population has not been systemically elucidated. METHODS: Analyses were based upon a cross-sectional study of 3259 participants with H-type hypertension who underwent assessment of biochemical, anthropometric and blood pressure values. Reduced GFR was considered if meeting estimated GFR <60 ml/min/1.73 m2. RESULTS: A stepwise multivariate regression analysis indicated that non-traditional lipid parameters remained as independent determinants of estimated GFR (all p < .001). In multivariable models, we observed a 50%, 51%, 31%, and 24% higher risk for decreased GFR with each SD increment in TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C levels, respectively. The highest quartile of TC/HDL-C, TG/HDL-C and LDL-C/HDL-C ratios carried reduced GFR odds (confidence intervals) of 5.50 (2.50 to 12.09), 6.63 (2.58 to 17.05) and 2.22 (1.15 to 4.29), respectively. CONCLUSIONS: The relative independent contribution of non-traditional lipid profiles, as indexed by TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C, towards reduced GFR putting research evidence at the very heart of lipoprotein-mediated renal injury set a vital example for applying a clinical and public health recommendation for reducing the burden of chronic kidney disease. KEY MESSAGES Non-traditional lipid profiles has been linked with the occurrence of cardiovascular disease, but none of the studies that address the effect of non-traditional lipid profiles on reduced GFR risk in H-type hypertension population has been specifically established. A greater emphasis of this study resided in the intrinsic value of TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C that integrate atherogenic and anti-atherogenic lipid molecules to predict the risk of reduced GFR among H-type hypertension population and provide insight into the pathophysiology of subsequent cardio-cerebrovascular outcomes. In a large Chinese H-type hypertension adults, the relative independent contribution of non-traditional lipid profiles, as indexed by TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C, towards reduced GFR putting research evidence at the very heart of lipoprotein-mediated renal injury set a vital example for applying a clinical and public health recommendation for reducing the burden of CKD. SN - 1365-2060 UR - https://www.unboundmedicine.com/medline/citation/29473759/Contribution_of_non_traditional_lipid_profiles_to_reduced_glomerular_filtration_rate_in_H_type_hypertension_population_of_rural_China_ L2 - https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1445277 DB - PRIME DP - Unbound Medicine ER -