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The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Horm Metab Res. 2018 Apr; 50(4):271-279.HM

Abstract

The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome (PCOS). Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related randomized-controlled articles (RCTs) published up to November 2017. Two researchers assessed study eligibility, extracted data, and evaluated risk of bias of included RCTs, independently. To check heterogeneity Q-test and I[2] statistics were used. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as summary effect size. Seven RCTs were included into our meta-analysis. The findings showed that vitamin D supplementation in women with PCOS significantly decreased high-sensitivity C-reactive protein (hs-CRP) (SMD -1.03; 95% CI, -1.58, -0.49; p <0.001) and malondialdehyde (MDA) (SMD -1.64, 95% CI -2.26 to -1.02, p <0.001), and significantly increased total antioxidant capacity (TAC) levels (SMD 0.86, 95% CI 0.08 to 1.64, p=0.03). Vitamin D supplementation had no significant effect on nitric oxide (NO) (SMD 0.11, 95% CI -0.44 to 0.66, p=0.69) and total glutathione (GSH) levels (SMD 0.54, 95% CI -0.20 to 1.28, p=0.15). Overall, the current meta-analysis demonstrated that vitamin D supplementation to women with PCOS resulted in an improvement in hs-CRP, MDA and TAC, but did not affect NO and GSH levels.

Authors+Show Affiliations

Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada.Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.Faculty member of Rehabilitation Management Department, School of Rehabilitation, University of Social Welfare and Rehabilitation Sciences (USWR),Tehran, Iran.Pure North S'Energy Foundation, Calgary, AB, Canada.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

29475212

Citation

Akbari, Maryam, et al. "The Effects of Vitamin D Supplementation On Biomarkers of Inflammation and Oxidative Stress Among Women With Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis of Randomized Controlled Trials." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 50, no. 4, 2018, pp. 271-279.
Akbari M, Ostadmohammadi V, Lankarani KB, et al. The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2018;50(4):271-279.
Akbari, M., Ostadmohammadi, V., Lankarani, K. B., Tabrizi, R., Kolahdooz, F., Heydari, S. T., Kavari, S. H., Mirhosseini, N., Mafi, A., Dastorani, M., & Asemi, Z. (2018). The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 50(4), 271-279. https://doi.org/10.1055/s-0044-101355
Akbari M, et al. The Effects of Vitamin D Supplementation On Biomarkers of Inflammation and Oxidative Stress Among Women With Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2018;50(4):271-279. PubMed PMID: 29475212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. AU - Akbari,Maryam, AU - Ostadmohammadi,Vahidreza, AU - Lankarani,Kamran B, AU - Tabrizi,Reza, AU - Kolahdooz,Fariba, AU - Heydari,Seyed Taghi, AU - Kavari,Seyed Habibollah, AU - Mirhosseini,Naghmeh, AU - Mafi,Alireza, AU - Dastorani,Majid, AU - Asemi,Zatollah, Y1 - 2018/02/23/ PY - 2018/2/24/pubmed PY - 2018/9/15/medline PY - 2018/2/24/entrez SP - 271 EP - 279 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 50 IS - 4 N2 - The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome (PCOS). Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related randomized-controlled articles (RCTs) published up to November 2017. Two researchers assessed study eligibility, extracted data, and evaluated risk of bias of included RCTs, independently. To check heterogeneity Q-test and I[2] statistics were used. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as summary effect size. Seven RCTs were included into our meta-analysis. The findings showed that vitamin D supplementation in women with PCOS significantly decreased high-sensitivity C-reactive protein (hs-CRP) (SMD -1.03; 95% CI, -1.58, -0.49; p <0.001) and malondialdehyde (MDA) (SMD -1.64, 95% CI -2.26 to -1.02, p <0.001), and significantly increased total antioxidant capacity (TAC) levels (SMD 0.86, 95% CI 0.08 to 1.64, p=0.03). Vitamin D supplementation had no significant effect on nitric oxide (NO) (SMD 0.11, 95% CI -0.44 to 0.66, p=0.69) and total glutathione (GSH) levels (SMD 0.54, 95% CI -0.20 to 1.28, p=0.15). Overall, the current meta-analysis demonstrated that vitamin D supplementation to women with PCOS resulted in an improvement in hs-CRP, MDA and TAC, but did not affect NO and GSH levels. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/29475212/The_Effects_of_Vitamin_D_Supplementation_on_Biomarkers_of_Inflammation_and_Oxidative_Stress_Among_Women_with_Polycystic_Ovary_Syndrome:_A_Systematic_Review_and_Meta_Analysis_of_Randomized_Controlled_Trials_ DB - PRIME DP - Unbound Medicine ER -