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Pharmacological interventions for treating sialorrhea associated with neurological disorders: A mixed treatment network meta-analysis of randomized controlled trials.
J Clin Neurosci. 2018 May; 51:12-17.JC

Abstract

Sialorrhea is a common distress associated with certain neurological disorders. The aim of this study is to compare the pharmacological agents used for treating sialorrhea by network meta-analysis. Electronic databases were searched for randomized clinical trials comparing active drugs with either placebo or other active drugs. Total drooling scores was the primary outcome measure. Inverse variance heterogeneity model was used for both direct and mixed treatment comparison analysis. Twenty one studies were included in the systematic review and 15 in the meta-analysis. Compared to placebo, benztropine, botulinum toxins A and B are associated with a significant reduction in the frequency and severity of drooling both in the overall neurological disorders as well as for children with cerebral palsy. Only botulinum toxin A and B were associated with significant therapeutic effects in Parkinson's disease. Benztropine and botulinum toxins A and B were observed to be effective in reducing sialorrhea associated with neurological disorders.

Authors+Show Affiliations

Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain. Electronic address: skannandr@gmail.com.School of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

29475576

Citation

Sridharan, Kannan, and Gowri Sivaramakrishnan. "Pharmacological Interventions for Treating Sialorrhea Associated With Neurological Disorders: a Mixed Treatment Network Meta-analysis of Randomized Controlled Trials." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 51, 2018, pp. 12-17.
Sridharan K, Sivaramakrishnan G. Pharmacological interventions for treating sialorrhea associated with neurological disorders: A mixed treatment network meta-analysis of randomized controlled trials. J Clin Neurosci. 2018;51:12-17.
Sridharan, K., & Sivaramakrishnan, G. (2018). Pharmacological interventions for treating sialorrhea associated with neurological disorders: A mixed treatment network meta-analysis of randomized controlled trials. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 51, 12-17. https://doi.org/10.1016/j.jocn.2018.02.011
Sridharan K, Sivaramakrishnan G. Pharmacological Interventions for Treating Sialorrhea Associated With Neurological Disorders: a Mixed Treatment Network Meta-analysis of Randomized Controlled Trials. J Clin Neurosci. 2018;51:12-17. PubMed PMID: 29475576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological interventions for treating sialorrhea associated with neurological disorders: A mixed treatment network meta-analysis of randomized controlled trials. AU - Sridharan,Kannan, AU - Sivaramakrishnan,Gowri, Y1 - 2018/02/21/ PY - 2017/11/07/received PY - 2018/02/04/accepted PY - 2018/2/25/pubmed PY - 2018/8/22/medline PY - 2018/2/25/entrez KW - Amyotrophic lateral sclerosis KW - Benztropine KW - Botulinum toxin KW - Cerebral palsy KW - Glycopyrrolate KW - Parkinson’s disease KW - Scopolamine SP - 12 EP - 17 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 51 N2 - Sialorrhea is a common distress associated with certain neurological disorders. The aim of this study is to compare the pharmacological agents used for treating sialorrhea by network meta-analysis. Electronic databases were searched for randomized clinical trials comparing active drugs with either placebo or other active drugs. Total drooling scores was the primary outcome measure. Inverse variance heterogeneity model was used for both direct and mixed treatment comparison analysis. Twenty one studies were included in the systematic review and 15 in the meta-analysis. Compared to placebo, benztropine, botulinum toxins A and B are associated with a significant reduction in the frequency and severity of drooling both in the overall neurological disorders as well as for children with cerebral palsy. Only botulinum toxin A and B were associated with significant therapeutic effects in Parkinson's disease. Benztropine and botulinum toxins A and B were observed to be effective in reducing sialorrhea associated with neurological disorders. SN - 1532-2653 UR - https://www.unboundmedicine.com/medline/citation/29475576/Pharmacological_interventions_for_treating_sialorrhea_associated_with_neurological_disorders:_A_mixed_treatment_network_meta-analysis_of_randomized_controlled_trials L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(17)32016-7 DB - PRIME DP - Unbound Medicine ER -