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Moderate-to-high cardiovascular risk is associated with increased lower urinary tract storage symptoms in patients with benign prostatic enlargement.
Minerva Urol Nefrol. 2018 Jun; 70(3):340-346.MU

Abstract

BACKGROUND

To assess the association between cardiovascular risk (CVR) and lower urinary tract symptoms (LUTS) in men with benign prostatic enlargement (BPE).

METHODS

We enrolled a consecutive series of men with LUTS/BPE. International Prostate Symptom Score (IPSS), voiding (vIPSS) and storage (sIPSS) subscore and prostate volume were evaluated. We defined CVR according to the European Association of Cardiologist Guidelines, and metabolic syndrome (MetS) according to the Adult Treatment Panel III (ATP III).

RESULTS

A total of 509 patients were enrolled. Median age was 66 years (IQR: 60-72), IPSS 9 (IQR: 5-15), vIPSS 5 (IQR: 2-9), sIPSS 4 (IQR: 2-7), Prostate volume was 54 cc (IQR: 40-73). Overall 309/509 (60.7%) patients had a moderate/high CVR and 128/509 presented MetS (25.1%). 297/509 (58.3%) men had an IPSS>7 and 282/509 (55.4%) a sIPSS>3. Men with moderate-to-severe CVR had higher IPSS (9; IQR: 4-14 vs. 10; IQR: 5-16; P=0.01), higher vIPSS (6; IQR: 2-9 vs. 4; IQR: 2-8; P=0.06) and higher sIPSS (4; IQR: 2-8 vs. 3; IQR: 1-6; P=0.005) when compared with no/low CVR patients. On multivariate analysis CVR was associated with an increased risk of IPSS>7 (OR=1.794; 95% CI: 1.111-2.888; P=0.01) and sIPSS>3 (OR=1.593; 95% CI: 1.101-2.555; P=0.04).

CONCLUSIONS

A moderate/high CVR is associated with an increased risk of LUTS, particularly storage LUTS. Although the pathophysiology is yet to be understood, it can be assumed that an increased CVR may be associated with LUTS/BPE presence.

Authors+Show Affiliations

Department of Urology, Ospedale Sant'Andrea, Sapienza University, Rome, Italy - cosimodenunzio@virgilio.it.A. Reale Department of Heart and Great Vessels, Umberto I Polyclinic, Sapienza University, Rome, Italy.Department of Urology, Ospedale Sant'Andrea, Sapienza University, Rome, Italy.Department of Urology, Ospedale Sant'Andrea, Sapienza University, Rome, Italy.Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.A. Reale Department of Heart and Great Vessels, Umberto I Polyclinic, Sapienza University, Rome, Italy.Department of Urology, Ospedale Sant'Andrea, Sapienza University, Rome, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29478309

Citation

De Nunzio, Cosimo, et al. "Moderate-to-high Cardiovascular Risk Is Associated With Increased Lower Urinary Tract Storage Symptoms in Patients With Benign Prostatic Enlargement." Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology, vol. 70, no. 3, 2018, pp. 340-346.
De Nunzio C, Truscelli G, Presicce F, et al. Moderate-to-high cardiovascular risk is associated with increased lower urinary tract storage symptoms in patients with benign prostatic enlargement. Minerva Urol Nefrol. 2018;70(3):340-346.
De Nunzio, C., Truscelli, G., Presicce, F., Bellangino, M., Gacci, M., Gaudio, C., & Tubaro, A. (2018). Moderate-to-high cardiovascular risk is associated with increased lower urinary tract storage symptoms in patients with benign prostatic enlargement. Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology, 70(3), 340-346. https://doi.org/10.23736/S0393-2249.18.03107-7
De Nunzio C, et al. Moderate-to-high Cardiovascular Risk Is Associated With Increased Lower Urinary Tract Storage Symptoms in Patients With Benign Prostatic Enlargement. Minerva Urol Nefrol. 2018;70(3):340-346. PubMed PMID: 29478309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate-to-high cardiovascular risk is associated with increased lower urinary tract storage symptoms in patients with benign prostatic enlargement. AU - De Nunzio,Cosimo, AU - Truscelli,Giovanni, AU - Presicce,Fabrizio, AU - Bellangino,Mariangela, AU - Gacci,Mauro, AU - Gaudio,Carlo, AU - Tubaro,Andrea, Y1 - 2018/02/22/ PY - 2018/2/27/pubmed PY - 2018/11/8/medline PY - 2018/2/27/entrez SP - 340 EP - 346 JF - Minerva urologica e nefrologica = The Italian journal of urology and nephrology JO - Minerva Urol Nefrol VL - 70 IS - 3 N2 - BACKGROUND: To assess the association between cardiovascular risk (CVR) and lower urinary tract symptoms (LUTS) in men with benign prostatic enlargement (BPE). METHODS: We enrolled a consecutive series of men with LUTS/BPE. International Prostate Symptom Score (IPSS), voiding (vIPSS) and storage (sIPSS) subscore and prostate volume were evaluated. We defined CVR according to the European Association of Cardiologist Guidelines, and metabolic syndrome (MetS) according to the Adult Treatment Panel III (ATP III). RESULTS: A total of 509 patients were enrolled. Median age was 66 years (IQR: 60-72), IPSS 9 (IQR: 5-15), vIPSS 5 (IQR: 2-9), sIPSS 4 (IQR: 2-7), Prostate volume was 54 cc (IQR: 40-73). Overall 309/509 (60.7%) patients had a moderate/high CVR and 128/509 presented MetS (25.1%). 297/509 (58.3%) men had an IPSS>7 and 282/509 (55.4%) a sIPSS>3. Men with moderate-to-severe CVR had higher IPSS (9; IQR: 4-14 vs. 10; IQR: 5-16; P=0.01), higher vIPSS (6; IQR: 2-9 vs. 4; IQR: 2-8; P=0.06) and higher sIPSS (4; IQR: 2-8 vs. 3; IQR: 1-6; P=0.005) when compared with no/low CVR patients. On multivariate analysis CVR was associated with an increased risk of IPSS>7 (OR=1.794; 95% CI: 1.111-2.888; P=0.01) and sIPSS>3 (OR=1.593; 95% CI: 1.101-2.555; P=0.04). CONCLUSIONS: A moderate/high CVR is associated with an increased risk of LUTS, particularly storage LUTS. Although the pathophysiology is yet to be understood, it can be assumed that an increased CVR may be associated with LUTS/BPE presence. SN - 1827-1758 UR - https://www.unboundmedicine.com/medline/citation/29478309/Moderate_to_high_cardiovascular_risk_is_associated_with_increased_lower_urinary_tract_storage_symptoms_in_patients_with_benign_prostatic_enlargement_ L2 - https://www.minervamedica.it/index2.t?show=R19Y2018N03A0340 DB - PRIME DP - Unbound Medicine ER -