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Distinct effects of dietary ALA, EPA and DHA on rat adipose oxylipins vary by depot location and sex.

Abstract

Dietary EPA and DHA given together alter oxylipins in adipose tissue. To compare the separate effects of individual dietary n-3 PUFA on oxylipins in different adipose depots (gonadal, mesenteric, perirenal, subcutaneous) in males and females, rats were provided diets containing higher levels of α-linolenic acid (ALA), EPA or DHA. Each n-3 PUFA enhanced its respective oxylipins the most, while effects on other n-3 oxylipins varied. For example: in perirenal and subcutaneous depots, more DHA oxylipins were higher with dietary ALA than with EPA; dietary EPA uniquely decreased 14-hydroxy-docosahexaenoic acid, in contrast to increasing many other DHA oxylipins. The n-3 PUFAs also reduced oxylipins from n-6 PUFAs in order of effectiveness: DHA > EPA > ALA. Diet by sex interactions in all depots except the perirenal depot resulted in higher oxylipins in males given DHA, and higher oxylipins in females given the other diets. Diet and sex effects on oxylipins did not necessarily reflect effects on either their tissue phospholipid or neutral lipid PUFA precursors. These varying diet and sex effects on oxylipins in the different adipose sites indicate that they may have distinct effects on adipose function.

Authors+Show Affiliations

School of Medicine, Federal University of Uberlândia, Brazil; Department of Food and Human Nutritional Sciences, University of Manitoba, Canada.Department of Food and Human Nutritional Sciences, University of Manitoba, Canada.Department of Food and Human Nutritional Sciences, University of Manitoba, Canada.Department of Food and Human Nutritional Sciences, University of Manitoba, Canada.Department of Food and Human Nutritional Sciences, University of Manitoba, Canada.Department of Food and Human Nutritional Sciences, University of Manitoba, Canada; Canadian Centre for Research in Agri-Food Research in Health and Medicine, Winnipeg, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Canada.Department of Food and Human Nutritional Sciences, University of Manitoba, Canada; Canadian Centre for Research in Agri-Food Research in Health and Medicine, Winnipeg, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Canada.Department of Food and Human Nutritional Sciences, University of Manitoba, Canada; Canadian Centre for Research in Agri-Food Research in Health and Medicine, Winnipeg, Canada. Electronic address: harold.aukema@umanitoba.ca.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29482766

Citation

Mendonça, Anne M., et al. "Distinct Effects of Dietary ALA, EPA and DHA On Rat Adipose Oxylipins Vary By Depot Location and Sex." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 129, 2018, pp. 13-24.
Mendonça AM, Cayer LGJ, Pauls SD, et al. Distinct effects of dietary ALA, EPA and DHA on rat adipose oxylipins vary by depot location and sex. Prostaglandins Leukot Essent Fatty Acids. 2018;129:13-24.
Mendonça, A. M., Cayer, L. G. J., Pauls, S. D., Winter, T., Leng, S., Taylor, C. G., Zahradka, P., & Aukema, H. M. (2018). Distinct effects of dietary ALA, EPA and DHA on rat adipose oxylipins vary by depot location and sex. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 129, 13-24. https://doi.org/10.1016/j.plefa.2017.12.004
Mendonça AM, et al. Distinct Effects of Dietary ALA, EPA and DHA On Rat Adipose Oxylipins Vary By Depot Location and Sex. Prostaglandins Leukot Essent Fatty Acids. 2018;129:13-24. PubMed PMID: 29482766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distinct effects of dietary ALA, EPA and DHA on rat adipose oxylipins vary by depot location and sex. AU - Mendonça,Anne M, AU - Cayer,Lucien G J, AU - Pauls,Samantha D, AU - Winter,Tanja, AU - Leng,Shan, AU - Taylor,Carla G, AU - Zahradka,Peter, AU - Aukema,Harold M, Y1 - 2017/12/26/ PY - 2017/10/27/received PY - 2017/12/20/revised PY - 2017/12/22/accepted PY - 2018/2/28/entrez PY - 2018/2/28/pubmed PY - 2018/11/28/medline KW - ALA KW - Adipose depots KW - DHA KW - Dietary n-3 PUFA KW - EPA KW - Oxylipins KW - Rat KW - Sex SP - 13 EP - 24 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 129 N2 - Dietary EPA and DHA given together alter oxylipins in adipose tissue. To compare the separate effects of individual dietary n-3 PUFA on oxylipins in different adipose depots (gonadal, mesenteric, perirenal, subcutaneous) in males and females, rats were provided diets containing higher levels of α-linolenic acid (ALA), EPA or DHA. Each n-3 PUFA enhanced its respective oxylipins the most, while effects on other n-3 oxylipins varied. For example: in perirenal and subcutaneous depots, more DHA oxylipins were higher with dietary ALA than with EPA; dietary EPA uniquely decreased 14-hydroxy-docosahexaenoic acid, in contrast to increasing many other DHA oxylipins. The n-3 PUFAs also reduced oxylipins from n-6 PUFAs in order of effectiveness: DHA > EPA > ALA. Diet by sex interactions in all depots except the perirenal depot resulted in higher oxylipins in males given DHA, and higher oxylipins in females given the other diets. Diet and sex effects on oxylipins did not necessarily reflect effects on either their tissue phospholipid or neutral lipid PUFA precursors. These varying diet and sex effects on oxylipins in the different adipose sites indicate that they may have distinct effects on adipose function. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/29482766/Distinct_effects_of_dietary_ALA_EPA_and_DHA_on_rat_adipose_oxylipins_vary_by_depot_location_and_sex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(17)30266-1 DB - PRIME DP - Unbound Medicine ER -