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Prevalence of restless legs syndrome in Parkinson's disease: a systematic review and meta-analysis of observational studies.
Sleep Med. 2018 03; 43:40-46.SM

Abstract

OBJECTIVE

Restless legs syndrome (RLS) and Parkinson's disease (PD) are common neurological disorders that respond to dopaminergic therapy. RLS prevalence among people with PD varies widely (0-38%) in the literature, complicating efforts to understand whether the two diseases might be associated.

METHOD

The databases Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were searched for observational and case-control studies of RLS prevalence in PD. Eligible studies were meta-analyzed using Stata 12.0.

RESULTS

Pooled RLS prevalence in PD among various patient populations was 14%, and prevalence in Asia (12%) was slightly lower than outside Asia (16%). Prevalence was higher among patients who had previously received PD treatment (15%) than among drug-naïve patients (11%). Prevalence of RLS was higher in female PD patients (13%) than in male patients (11%). RLS prevalence was much higher among PD patients than among healthy controls (OR 2.86, 95% CI 2.10-3.90; p < 0.001).

CONCLUSION

This meta-analysis may provide the first reliable pooled estimate of RLS prevalence in PD, and strong evidence that RLS risk is higher among PD patients than among healthy individuals.

Authors+Show Affiliations

Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China; Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.Department of Rehabilitation, The Second People's Hospital of Jiang You, Mian Yang, People's Republic of China.Department of Anesthesia, Kunming Xishan District People's Hospital, Kunming, People's Republic of China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China. Electronic address: huiren2006@163.com.Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China. Electronic address: neuroxym999@163.com.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China. Electronic address: xuzhong118@126.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

29482811

Citation

Yang, Xinglong, et al. "Prevalence of Restless Legs Syndrome in Parkinson's Disease: a Systematic Review and Meta-analysis of Observational Studies." Sleep Medicine, vol. 43, 2018, pp. 40-46.
Yang X, Liu B, Shen H, et al. Prevalence of restless legs syndrome in Parkinson's disease: a systematic review and meta-analysis of observational studies. Sleep Med. 2018;43:40-46.
Yang, X., Liu, B., Shen, H., Li, S., Zhao, Q., An, R., Hu, F., Ren, H., Xu, Y., & Xu, Z. (2018). Prevalence of restless legs syndrome in Parkinson's disease: a systematic review and meta-analysis of observational studies. Sleep Medicine, 43, 40-46. https://doi.org/10.1016/j.sleep.2017.11.1146
Yang X, et al. Prevalence of Restless Legs Syndrome in Parkinson's Disease: a Systematic Review and Meta-analysis of Observational Studies. Sleep Med. 2018;43:40-46. PubMed PMID: 29482811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of restless legs syndrome in Parkinson's disease: a systematic review and meta-analysis of observational studies. AU - Yang,Xinglong, AU - Liu,Bin, AU - Shen,Hao, AU - Li,Shimei, AU - Zhao,Quanzhen, AU - An,Ran, AU - Hu,Fayun, AU - Ren,Hui, AU - Xu,Yanming, AU - Xu,Zhong, Y1 - 2018/01/31/ PY - 2017/09/03/received PY - 2017/10/07/revised PY - 2017/11/13/accepted PY - 2018/2/28/entrez PY - 2018/2/28/pubmed PY - 2019/9/20/medline KW - Parkinson's disease KW - Prevalence KW - Restless legs syndrome SP - 40 EP - 46 JF - Sleep medicine JO - Sleep Med VL - 43 N2 - OBJECTIVE: Restless legs syndrome (RLS) and Parkinson's disease (PD) are common neurological disorders that respond to dopaminergic therapy. RLS prevalence among people with PD varies widely (0-38%) in the literature, complicating efforts to understand whether the two diseases might be associated. METHOD: The databases Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were searched for observational and case-control studies of RLS prevalence in PD. Eligible studies were meta-analyzed using Stata 12.0. RESULTS: Pooled RLS prevalence in PD among various patient populations was 14%, and prevalence in Asia (12%) was slightly lower than outside Asia (16%). Prevalence was higher among patients who had previously received PD treatment (15%) than among drug-naïve patients (11%). Prevalence of RLS was higher in female PD patients (13%) than in male patients (11%). RLS prevalence was much higher among PD patients than among healthy controls (OR 2.86, 95% CI 2.10-3.90; p < 0.001). CONCLUSION: This meta-analysis may provide the first reliable pooled estimate of RLS prevalence in PD, and strong evidence that RLS risk is higher among PD patients than among healthy individuals. SN - 1878-5506 UR - https://www.unboundmedicine.com/medline/citation/29482811/Prevalence_of_restless_legs_syndrome_in_Parkinson's_disease:_a_systematic_review_and_meta_analysis_of_observational_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(17)31600-3 DB - PRIME DP - Unbound Medicine ER -