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Concordance of gonorrhoea of the rectum, pharynx and urethra in same-sex male partnerships attending a sexual health service in Melbourne, Australia.
BMC Infect Dis. 2018 02 27; 18(1):95.BI

Abstract

BACKGROUND

We aimed to describe anatomic site-specific concordance of gonococcal infections in partnerships of men who have sex with men (MSM).

METHODS

We conducted a cross-sectional analysis of data from MSM partnerships attending Melbourne Sexual Health Centre between March 2011 and February 2015. Logistic regression models (random effect) were used to examine the association between gonococcal infections of the urethra, rectum and pharynx. Gonococci were detected by culture at all anatomic sites.

RESULTS

The analysis included 495 partnerships. Of the men with urethral gonorrhoea, 33% (95% CI 18-52) had partners with pharyngeal gonorrhoea and 67% (95% CI 48-82) had partners with rectal gonorrhoea. The adjusted odds of having urethral gonorrhoea was 4.6 (95% CI 1.2-17.1) for a man whose partner had pharyngeal gonorrhoea, and 48.1 (95% CI 18.3-126.7) for a man whose partner had rectal gonorrhoea. Of the men with rectal gonorrhoea, 46% (95% CI 31-61) had a partner with urethral gonorrhoea and 23% (95% CI 12-37) had a partner with pharyngeal gonorrhoea. The adjusted odds of having rectal gonorrhoea was 63.9 (95% CI 24.7-165.6) for a man whose partner had urethral gonorrhoea. Of the men with pharyngeal gonorrhoea, 42% (95% CI 23-63) had a partner with rectal gonorrhoea and 23% (95% CI 9-44) had a partner with had a partner with pharyngeal gonorrhoea. The adjusted odds of having pharyngeal gonorrhoea was 8.9 (95% CI 3.2-24.6) for a man whose partner had rectal gonorrhoea. The crude odds of having pharyngeal gonorrhoea was 14.2 (95% CI 5.1-39.0) for a man whose partner had pharyngeal gonorrhoea.

CONCLUSIONS

These data provide the first estimates of concordance of anatomic site-specific gonococcal infections in MSM partnerships, and confirm that urethral gonorrhoea is contracted from both rectal and pharyngeal sites, and suggest that gonococci transmit between the rectum and pharynx. However, due to use of culture rather than NAAT, our analysis was not adequately powered to assess pharynx-to-pharynx transmission of gonococci.

Authors+Show Affiliations

The Melbourne Sexual Health Centre, Alfred Health, 580 Swanston St, Carlton, Melbourne, VIC, 3053, Australia. VCornelisse@mshc.org.au. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia. VCornelisse@mshc.org.au.The Melbourne Sexual Health Centre, Alfred Health, 580 Swanston St, Carlton, Melbourne, VIC, 3053, Australia. The Kirby Institute, UNSW Sydney, Sydney, Australia.The Kirby Institute, UNSW Sydney, Sydney, Australia.The Melbourne Sexual Health Centre, Alfred Health, 580 Swanston St, Carlton, Melbourne, VIC, 3053, Australia. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.The Melbourne Sexual Health Centre, Alfred Health, 580 Swanston St, Carlton, Melbourne, VIC, 3053, Australia. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.The Melbourne Sexual Health Centre, Alfred Health, 580 Swanston St, Carlton, Melbourne, VIC, 3053, Australia. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.The Melbourne Sexual Health Centre, Alfred Health, 580 Swanston St, Carlton, Melbourne, VIC, 3053, Australia. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.The Melbourne Sexual Health Centre, Alfred Health, 580 Swanston St, Carlton, Melbourne, VIC, 3053, Australia. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29486706

Citation

Cornelisse, Vincent J., et al. "Concordance of Gonorrhoea of the Rectum, Pharynx and Urethra in Same-sex Male Partnerships Attending a Sexual Health Service in Melbourne, Australia." BMC Infectious Diseases, vol. 18, no. 1, 2018, p. 95.
Cornelisse VJ, Zhang L, Law M, et al. Concordance of gonorrhoea of the rectum, pharynx and urethra in same-sex male partnerships attending a sexual health service in Melbourne, Australia. BMC Infect Dis. 2018;18(1):95.
Cornelisse, V. J., Zhang, L., Law, M., Chen, M. Y., Bradshaw, C. S., Bellhouse, C., Fairley, C. K., & Chow, E. P. F. (2018). Concordance of gonorrhoea of the rectum, pharynx and urethra in same-sex male partnerships attending a sexual health service in Melbourne, Australia. BMC Infectious Diseases, 18(1), 95. https://doi.org/10.1186/s12879-018-3003-2
Cornelisse VJ, et al. Concordance of Gonorrhoea of the Rectum, Pharynx and Urethra in Same-sex Male Partnerships Attending a Sexual Health Service in Melbourne, Australia. BMC Infect Dis. 2018 02 27;18(1):95. PubMed PMID: 29486706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concordance of gonorrhoea of the rectum, pharynx and urethra in same-sex male partnerships attending a sexual health service in Melbourne, Australia. AU - Cornelisse,Vincent J, AU - Zhang,Lei, AU - Law,Matthew, AU - Chen,Marcus Y, AU - Bradshaw,Catriona S, AU - Bellhouse,Clare, AU - Fairley,Christopher K, AU - Chow,Eric P F, Y1 - 2018/02/27/ PY - 2017/02/01/received PY - 2018/02/21/accepted PY - 2018/3/1/entrez PY - 2018/3/1/pubmed PY - 2018/5/22/medline KW - Disease transmission KW - Gonorrhea [C12.294.668.281.401] KW - Homosexuality [F01.145.802.975.500] KW - Infectious [N06.850.310] KW - Pharynx [A14.724] KW - Sexual partners [M01.778] SP - 95 EP - 95 JF - BMC infectious diseases JO - BMC Infect Dis VL - 18 IS - 1 N2 - BACKGROUND: We aimed to describe anatomic site-specific concordance of gonococcal infections in partnerships of men who have sex with men (MSM). METHODS: We conducted a cross-sectional analysis of data from MSM partnerships attending Melbourne Sexual Health Centre between March 2011 and February 2015. Logistic regression models (random effect) were used to examine the association between gonococcal infections of the urethra, rectum and pharynx. Gonococci were detected by culture at all anatomic sites. RESULTS: The analysis included 495 partnerships. Of the men with urethral gonorrhoea, 33% (95% CI 18-52) had partners with pharyngeal gonorrhoea and 67% (95% CI 48-82) had partners with rectal gonorrhoea. The adjusted odds of having urethral gonorrhoea was 4.6 (95% CI 1.2-17.1) for a man whose partner had pharyngeal gonorrhoea, and 48.1 (95% CI 18.3-126.7) for a man whose partner had rectal gonorrhoea. Of the men with rectal gonorrhoea, 46% (95% CI 31-61) had a partner with urethral gonorrhoea and 23% (95% CI 12-37) had a partner with pharyngeal gonorrhoea. The adjusted odds of having rectal gonorrhoea was 63.9 (95% CI 24.7-165.6) for a man whose partner had urethral gonorrhoea. Of the men with pharyngeal gonorrhoea, 42% (95% CI 23-63) had a partner with rectal gonorrhoea and 23% (95% CI 9-44) had a partner with had a partner with pharyngeal gonorrhoea. The adjusted odds of having pharyngeal gonorrhoea was 8.9 (95% CI 3.2-24.6) for a man whose partner had rectal gonorrhoea. The crude odds of having pharyngeal gonorrhoea was 14.2 (95% CI 5.1-39.0) for a man whose partner had pharyngeal gonorrhoea. CONCLUSIONS: These data provide the first estimates of concordance of anatomic site-specific gonococcal infections in MSM partnerships, and confirm that urethral gonorrhoea is contracted from both rectal and pharyngeal sites, and suggest that gonococci transmit between the rectum and pharynx. However, due to use of culture rather than NAAT, our analysis was not adequately powered to assess pharynx-to-pharynx transmission of gonococci. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/29486706/Concordance_of_gonorrhoea_of_the_rectum_pharynx_and_urethra_in_same_sex_male_partnerships_attending_a_sexual_health_service_in_Melbourne_Australia_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3003-2 DB - PRIME DP - Unbound Medicine ER -