Tags

Type your tag names separated by a space and hit enter

Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island.
Epidemiol Infect. 2018 04; 146(5):633-641.EI

Abstract

Prolonged fatigue is increasingly reported among chikungunya virus (CHIKV)-infected populations. We investigated the relationships between CHIKV exposure, long-lasting rheumatic musculoskeletal pain (LRMSP) and chronic fatigue. 1094 participants (512 CHIKV seropositive and 582 seronegative) of the TELECHIK population-based cohort were analysed considering the duration of the manifestations throughout an average 2-year follow-up. Weighted prevalence rates and prevalence ratios for LRMSP, idiopathic chronic fatigue (ICF), and chronic fatigue syndrome (CFS)-like illness, both latter syndromes adapted from Centers for Disease Control (CDC)-1994/Fukuda criteria, were compared. Population attributable fractions (PAF) were estimated to assess the contribution of CHIKV infection to each of the three phenotypes. Among 362 adult subjects who had reported either rheumatic pain or fatigue at the onset of the infection, weighted prevalence rates of LRMSP, ICF and CFS-like illness were respectively of 32.9%, 38.7% and 23.9%, and of 8.7%, 8.5% and 7.4% among initially asymptomatic peers (P < 0.01, respectively). Each of the three outcomes was highly attributable to chikungunya (PAF of 43.2%, 36.2% and 41.0%, respectively). In the sub-cohort of CHIKV-infected subjects, LRMSP, ICF and CFS-like illness, which overlapped in 70%, accounted for 53% of the chronic manifestations. In addition to rheumatic disease, chronic fatigue could be considered in caring for patients with chronic chikungunya disease.

Authors+Show Affiliations

Department of Tropical Medicine and Clinical International Health, Division of Infectious Diseases and Tropical Medicine, CHU Bordeaux, Bordeaux, France. Infectious Diseases in Low Income Countries (IDLIC), Bordeaux Population Health Research Centre (INSERM U1219, Université de Bordeaux, ISPED), Bordeaux, France.INSERM CIC 1410, CHU Réunion, Saint Pierre, Reunion.Department of Infectious Diseases, CHU Réunion, Saint Pierre, Reunion.Bacteriology, Virology and Parasitology lab, CHU Réunion, Saint Pierre, Reunion.Bacteriology, Virology and Parasitology lab, CHU Réunion, Saint Pierre, Reunion.Department of Infectious Diseases, CHU Réunion, Saint Pierre, Reunion.INSERM CIC 1410, CHU Réunion, Saint Pierre, Reunion. Department of Social and Preventive Medicine, School of Public Health, Montreal University, Montreal, Canada.Department of Tropical Medicine and Clinical International Health, Division of Infectious Diseases and Tropical Medicine, CHU Bordeaux, Bordeaux, France. Infectious Diseases in Low Income Countries (IDLIC), Bordeaux Population Health Research Centre (INSERM U1219, Université de Bordeaux, ISPED), Bordeaux, France.Polyvalent Intensive Care Unit, CHU Réunion, Saint Denis, Reunion.INSERM CIC 1410, CHU Réunion, Saint Pierre, Reunion.Department of Tropical Medicine and Clinical International Health, Division of Infectious Diseases and Tropical Medicine, CHU Bordeaux, Bordeaux, France. Infectious Diseases in Low Income Countries (IDLIC), Bordeaux Population Health Research Centre (INSERM U1219, Université de Bordeaux, ISPED), Bordeaux, France.INSERM CIC 1410, CHU Réunion, Saint Pierre, Reunion. UM 134 PIMIT Processus infectieux en Milieu Insulaire Tropical (Université de La Réunion, CNRS 919, INSERM U 1187, IRD 249), CYROI, Sainte Clotilde, Reunion.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29486812

Citation

Duvignaud, A, et al. "Rheumatism and Chronic Fatigue, the Two Facets of Post-chikungunya Disease: the TELECHIK Cohort Study On Reunion Island." Epidemiology and Infection, vol. 146, no. 5, 2018, pp. 633-641.
Duvignaud A, Fianu A, Bertolotti A, et al. Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island. Epidemiol Infect. 2018;146(5):633-641.
Duvignaud, A., Fianu, A., Bertolotti, A., Jaubert, J., Michault, A., Poubeau, P., Fred, A., Méchain, M., Gaüzère, B. A., Favier, F., Malvy, D., & Gérardin, P. (2018). Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island. Epidemiology and Infection, 146(5), 633-641. https://doi.org/10.1017/S0950268818000031
Duvignaud A, et al. Rheumatism and Chronic Fatigue, the Two Facets of Post-chikungunya Disease: the TELECHIK Cohort Study On Reunion Island. Epidemiol Infect. 2018;146(5):633-641. PubMed PMID: 29486812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island. AU - Duvignaud,A, AU - Fianu,A, AU - Bertolotti,A, AU - Jaubert,J, AU - Michault,A, AU - Poubeau,P, AU - Fred,A, AU - Méchain,M, AU - Gaüzère,B-A, AU - Favier,F, AU - Malvy,D, AU - Gérardin,P, Y1 - 2018/02/28/ PY - 2018/3/1/pubmed PY - 2018/12/21/medline PY - 2018/3/1/entrez KW - Alphavirus KW - chikungunya KW - chronic fatigue KW - cohort study KW - rheumatic disease SP - 633 EP - 641 JF - Epidemiology and infection JO - Epidemiol Infect VL - 146 IS - 5 N2 - Prolonged fatigue is increasingly reported among chikungunya virus (CHIKV)-infected populations. We investigated the relationships between CHIKV exposure, long-lasting rheumatic musculoskeletal pain (LRMSP) and chronic fatigue. 1094 participants (512 CHIKV seropositive and 582 seronegative) of the TELECHIK population-based cohort were analysed considering the duration of the manifestations throughout an average 2-year follow-up. Weighted prevalence rates and prevalence ratios for LRMSP, idiopathic chronic fatigue (ICF), and chronic fatigue syndrome (CFS)-like illness, both latter syndromes adapted from Centers for Disease Control (CDC)-1994/Fukuda criteria, were compared. Population attributable fractions (PAF) were estimated to assess the contribution of CHIKV infection to each of the three phenotypes. Among 362 adult subjects who had reported either rheumatic pain or fatigue at the onset of the infection, weighted prevalence rates of LRMSP, ICF and CFS-like illness were respectively of 32.9%, 38.7% and 23.9%, and of 8.7%, 8.5% and 7.4% among initially asymptomatic peers (P < 0.01, respectively). Each of the three outcomes was highly attributable to chikungunya (PAF of 43.2%, 36.2% and 41.0%, respectively). In the sub-cohort of CHIKV-infected subjects, LRMSP, ICF and CFS-like illness, which overlapped in 70%, accounted for 53% of the chronic manifestations. In addition to rheumatic disease, chronic fatigue could be considered in caring for patients with chronic chikungunya disease. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/29486812/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0950268818000031/type/journal_article DB - PRIME DP - Unbound Medicine ER -