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[Apathy, depression and cognitive functioning in patients with MCI and dementia].
Tijdschr Gerontol Geriatr. 2018 Jun; 49(3):95-102.TG

Abstract

BACKGROUND

In dementia, apathy and depression are often seen as one disorder because of the many overlapping symptoms. However, for therapy a correct differentiation is essential. Moreover, apathy and depression are likely both associated with different cognitive deficits and progression of the disease. In this research we give an overview of cognitive domains associated with apathy and depression in MCI patients and report how often both disorders occur in a population sample.

METHOD

We administered the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to 117 cognitively healthy controls (GC), 97 patients with mild cognitive impairment (MCI) and 50 patients with dementia (DEM). In addition, the Apathy Evaluation Scale clinical version (AES-C) and the Geriatric Depression Scale (GDS) were administered.

RESULTS

The number of patients with apathy increased with cognitive decline with respectively 3.4%, 10.4% and 41.5% of patients in the GC, MCI and DEM group. The prevalence of isolated depression was highest in the MCI group (18.8%). Correlation analyses in the MCI group showed that apathy and not depression was associated with a deficit in encoding, attention and global cognitive functioning.

CONCLUSION

The prevalence of apathy and depressive symptoms is different in patients with MCI, DEM and GC, and within the MCI group apathy and depression are associated with different cognitive domains.

Authors+Show Affiliations

Thomas More Hogeschool, Antwerpen, België. Referentiecentrum voor Biologische Markers van Dementie, Universiteit Antwerpen, Antwerpen, België.Universitair Medisch Centrum Groningen, Afdeling Neurowetenschappen, Rijksuniversiteit Groningen, Groningen, Nederland.Referentiecentrum voor Biologische Markers van Dementie, Universiteit Antwerpen, Antwerpen, België. Departement Neurologie en Geheugenkliniek, ZNA Middelheim en Hoge Beuken, Antwerpen, België. Universitair Medisch Centrum Groningen, Afdeling Neurologie en Alzheimer Research Centrum, Rijksuniversiteit Groningen, Groningen, Nederland.Referentiecentrum voor Biologische Markers van Dementie, Universiteit Antwerpen, Antwerpen, België. Departement Neurologie en Geheugenkliniek, ZNA Middelheim en Hoge Beuken, Antwerpen, België.Referentiecentrum voor Biologische Markers van Dementie, Universiteit Antwerpen, Antwerpen, België. ellen.deroeck@uantwerpen.be. Departement psychologie en educatiewetenschappen, Vrije Universiteit Brussel, Brussel, België. ellen.deroeck@uantwerpen.be. Departement Biomedische Wetenschappen, Campus Drie Eiken, Universiteit Antwerpen, Wilrijk, België. ellen.deroeck@uantwerpen.be.

Pub Type(s)

Journal Article

Language

dut

PubMed ID

29488192

Citation

Vloeberghs, Robin, et al. "[Apathy, Depression and Cognitive Functioning in Patients With MCI and Dementia]." Tijdschrift Voor Gerontologie En Geriatrie, vol. 49, no. 3, 2018, pp. 95-102.
Vloeberghs R, Opmeer EM, De Deyn PP, et al. [Apathy, depression and cognitive functioning in patients with MCI and dementia]. Tijdschr Gerontol Geriatr. 2018;49(3):95-102.
Vloeberghs, R., Opmeer, E. M., De Deyn, P. P., Engelborghs, S., & De Roeck, E. E. (2018). [Apathy, depression and cognitive functioning in patients with MCI and dementia]. Tijdschrift Voor Gerontologie En Geriatrie, 49(3), 95-102. https://doi.org/10.1007/s12439-018-0248-6
Vloeberghs R, et al. [Apathy, Depression and Cognitive Functioning in Patients With MCI and Dementia]. Tijdschr Gerontol Geriatr. 2018;49(3):95-102. PubMed PMID: 29488192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Apathy, depression and cognitive functioning in patients with MCI and dementia]. AU - Vloeberghs,Robin, AU - Opmeer,Esther M, AU - De Deyn,Peter P, AU - Engelborghs,Sebastiaan, AU - De Roeck,Ellen E, Y1 - 2018/02/27/ PY - 2017/08/16/received PY - 2018/02/01/accepted PY - 2018/3/1/pubmed PY - 2018/11/28/medline PY - 2018/3/1/entrez KW - Apathy KW - Cognitive functioning KW - Dementia KW - Depression KW - MCI SP - 95 EP - 102 JF - Tijdschrift voor gerontologie en geriatrie JO - Tijdschr Gerontol Geriatr VL - 49 IS - 3 N2 - BACKGROUND: In dementia, apathy and depression are often seen as one disorder because of the many overlapping symptoms. However, for therapy a correct differentiation is essential. Moreover, apathy and depression are likely both associated with different cognitive deficits and progression of the disease. In this research we give an overview of cognitive domains associated with apathy and depression in MCI patients and report how often both disorders occur in a population sample. METHOD: We administered the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to 117 cognitively healthy controls (GC), 97 patients with mild cognitive impairment (MCI) and 50 patients with dementia (DEM). In addition, the Apathy Evaluation Scale clinical version (AES-C) and the Geriatric Depression Scale (GDS) were administered. RESULTS: The number of patients with apathy increased with cognitive decline with respectively 3.4%, 10.4% and 41.5% of patients in the GC, MCI and DEM group. The prevalence of isolated depression was highest in the MCI group (18.8%). Correlation analyses in the MCI group showed that apathy and not depression was associated with a deficit in encoding, attention and global cognitive functioning. CONCLUSION: The prevalence of apathy and depressive symptoms is different in patients with MCI, DEM and GC, and within the MCI group apathy and depression are associated with different cognitive domains. SN - 0167-9228 UR - https://www.unboundmedicine.com/medline/citation/29488192/[Apathy_depression_and_cognitive_functioning_in_patients_with_MCI_and_dementia]_ L2 - https://dx.doi.org/10.1007/s12439-018-0248-6 DB - PRIME DP - Unbound Medicine ER -