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Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.
Biol Chem 2018; 399(9):1079-1084BC

Abstract

Kallikrein-related peptidases KLK5, KLK7 and KLK14 are important proteases in skin desquamation and aberrant KLK activity is associated with inflammatory skin diseases such as Netherton syndrome but also with various serious forms of cancer. Previously, we have identified KLK7 as the first protease target of vaspin (Serpin A12). Here, we report KLK14 as a second KLK protease to be inhibited by vaspin. In conclusion, vaspin represents a multi-specific serpin targeting the kallikrein proteases KLK7 and KLK14, with distinct exosites regulating recognition of these target proteases and opposing effects of heparin binding on the inhibition reaction.

Authors+Show Affiliations

Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstrasse 34, D-04103 Leipzig, Germany.Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstrasse 34, D-04103 Leipzig, Germany.Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstrasse 34, D-04103 Leipzig, Germany.Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, D-04103 Leipzig, Germany.Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, D-04103 Leipzig, Germany.Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstrasse 34, D-04103 Leipzig, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29494334

Citation

Ulbricht, David, et al. "Kallikrein-related Peptidase 14 Is the Second KLK Protease Targeted By the Serpin Vaspin." Biological Chemistry, vol. 399, no. 9, 2018, pp. 1079-1084.
Ulbricht D, Tindall CA, Oertwig K, et al. Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin. Biol Chem. 2018;399(9):1079-1084.
Ulbricht, D., Tindall, C. A., Oertwig, K., Hanke, S., Sträter, N., & Heiker, J. T. (2018). Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin. Biological Chemistry, 399(9), pp. 1079-1084. doi:10.1515/hsz-2018-0108.
Ulbricht D, et al. Kallikrein-related Peptidase 14 Is the Second KLK Protease Targeted By the Serpin Vaspin. Biol Chem. 2018 09 25;399(9):1079-1084. PubMed PMID: 29494334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin. AU - Ulbricht,David, AU - Tindall,Catherine A, AU - Oertwig,Kathrin, AU - Hanke,Stefanie, AU - Sträter,Norbert, AU - Heiker,John T, PY - 2018/01/08/received PY - 2018/02/23/accepted PY - 2018/3/2/pubmed PY - 2019/5/14/medline PY - 2018/3/2/entrez KW - adipokine KW - diabetes KW - exosite KW - inflammation KW - kallikrein KW - metabolic syndrome KW - obesity KW - serine protease KW - serpin A12 KW - site-directed mutagenesis KW - structural biology SP - 1079 EP - 1084 JF - Biological chemistry JO - Biol. Chem. VL - 399 IS - 9 N2 - Kallikrein-related peptidases KLK5, KLK7 and KLK14 are important proteases in skin desquamation and aberrant KLK activity is associated with inflammatory skin diseases such as Netherton syndrome but also with various serious forms of cancer. Previously, we have identified KLK7 as the first protease target of vaspin (Serpin A12). Here, we report KLK14 as a second KLK protease to be inhibited by vaspin. In conclusion, vaspin represents a multi-specific serpin targeting the kallikrein proteases KLK7 and KLK14, with distinct exosites regulating recognition of these target proteases and opposing effects of heparin binding on the inhibition reaction. SN - 1437-4315 UR - https://www.unboundmedicine.com/medline/citation/29494334/Kallikrein_related_peptidase_14_is_the_second_KLK_protease_targeted_by_the_serpin_vaspin_ L2 - https://www.degruyter.com/doi/10.1515/hsz-2018-0108 DB - PRIME DP - Unbound Medicine ER -