Tags

Type your tag names separated by a space and hit enter

[Exposure to bisphenol A during maternal pregnancy and the emotional and behavioral impact on their preschool children].
Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Feb 10; 39(2):188-193.ZL

Abstract

Objective:

To explore the long-term effects of maternal pregnancy bisphenol A (BPA) exposure on emotional and behavioral problems appeared in their preschool children.

Methods:

The study sample was a subset of the China-Anhui Birth Cohort Study (C-ABCS). A unified questionnaire was used to collect basic information on both pregnant women and their children. Free BPA concentration in maternal serum was determined by high-performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS). The parent-report version of the Strengths and Difficulties Questionnaire (SDQ) was used to estimate the emotional and behavioral problems in preschool children. A total of 1 713 pairs of mothers and children were included in this study. Association between BPA exposure during pregnancy and the emotional and behavioral problems in preschool children was evaluated with multinomial logistic regression model.

Results:

Prevalence rates in 1 713 preschool children appeared as: 6.48% of emotional problems, 8.11% for conduct problems, 8.35% for hyperactivity/inattention, 2.86% for peer problems, 11.38% for prosocial behaviors and 7.94% for total difficulties. Subjects were divided according to the degrees of exposure and the results showed as: low exposure group (≤0.120 ng/ml), medium exposure group (0.120<BPA<0.400 ng/ml) and high exposure group (≥0.400 ng/ml) according to the serum BPA concentration in tertile. Results from the multivariate logistic regression analysis showed that high level of maternal BPA exposure appeared a risk factor on children's abnormal conducts (OR=1.876, 95% CI: 1.161-3.029), more obvious in boys (OR=2.291, 95%CI: 1.126-4.661).

Conclusion:

Maternal exposure to high level of BPA during pregnancy might increase the detrimental effects of abnormal conducts in their preschool children, more obviously seen in boys.

Authors+Show Affiliations

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China.Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China.Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China.Ma'anshan Maternal and Child Health Center, Ma'anshan 243000, China.Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China.Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China.Ma'anshan Maternal and Child Health Center, Ma'anshan 243000, China.Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China.Ma'anshan Maternal and Child Health Center, Ma'anshan 243000, China.Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China.Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China.Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29495203

Citation

Chen, X, et al. "[Exposure to Bisphenol a During Maternal Pregnancy and the Emotional and Behavioral Impact On Their Preschool Children]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 39, no. 2, 2018, pp. 188-193.
Chen X, Bao HH, Wu WK, et al. [Exposure to bisphenol A during maternal pregnancy and the emotional and behavioral impact on their preschool children]. Zhonghua Liu Xing Bing Xue Za Zhi. 2018;39(2):188-193.
Chen, X., Bao, H. H., Wu, W. K., Yan, S. Q., Sheng, J., Xu, Y. Y., Gu, C. L., Huang, K., Cao, H., Su, P. Y., Tao, F. B., & Hao, J. H. (2018). [Exposure to bisphenol A during maternal pregnancy and the emotional and behavioral impact on their preschool children]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 39(2), 188-193. https://doi.org/10.3760/cma.j.issn.0254-6450.2018.02.010
Chen X, et al. [Exposure to Bisphenol a During Maternal Pregnancy and the Emotional and Behavioral Impact On Their Preschool Children]. Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Feb 10;39(2):188-193. PubMed PMID: 29495203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Exposure to bisphenol A during maternal pregnancy and the emotional and behavioral impact on their preschool children]. AU - Chen,X, AU - Bao,H H, AU - Wu,W K, AU - Yan,S Q, AU - Sheng,J, AU - Xu,Y Y, AU - Gu,C L, AU - Huang,K, AU - Cao,H, AU - Su,P Y, AU - Tao,F B, AU - Hao,J H, PY - 2018/3/2/entrez PY - 2018/3/2/pubmed PY - 2018/5/2/medline KW - Bisphenol A KW - Child behavior KW - Pregnancy SP - 188 EP - 193 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 39 IS - 2 N2 - Objective: To explore the long-term effects of maternal pregnancy bisphenol A (BPA) exposure on emotional and behavioral problems appeared in their preschool children. Methods: The study sample was a subset of the China-Anhui Birth Cohort Study (C-ABCS). A unified questionnaire was used to collect basic information on both pregnant women and their children. Free BPA concentration in maternal serum was determined by high-performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS). The parent-report version of the Strengths and Difficulties Questionnaire (SDQ) was used to estimate the emotional and behavioral problems in preschool children. A total of 1 713 pairs of mothers and children were included in this study. Association between BPA exposure during pregnancy and the emotional and behavioral problems in preschool children was evaluated with multinomial logistic regression model. Results: Prevalence rates in 1 713 preschool children appeared as: 6.48% of emotional problems, 8.11% for conduct problems, 8.35% for hyperactivity/inattention, 2.86% for peer problems, 11.38% for prosocial behaviors and 7.94% for total difficulties. Subjects were divided according to the degrees of exposure and the results showed as: low exposure group (≤0.120 ng/ml), medium exposure group (0.120<BPA<0.400 ng/ml) and high exposure group (≥0.400 ng/ml) according to the serum BPA concentration in tertile. Results from the multivariate logistic regression analysis showed that high level of maternal BPA exposure appeared a risk factor on children's abnormal conducts (OR=1.876, 95% CI: 1.161-3.029), more obvious in boys (OR=2.291, 95%CI: 1.126-4.661). Conclusion: Maternal exposure to high level of BPA during pregnancy might increase the detrimental effects of abnormal conducts in their preschool children, more obviously seen in boys. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/29495203/[Exposure_to_bisphenol_A_during_maternal_pregnancy_and_the_emotional_and_behavioral_impact_on_their_preschool_children]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0254-6450&amp;year=2018&amp;vol=39&amp;issue=2&amp;fpage=188 DB - PRIME DP - Unbound Medicine ER -