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MERS-CoV: Understanding the Latest Human Coronavirus Threat.
Viruses. 2018 02 24; 10(2)V

Abstract

Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi Arabia. The aetiological agent was eventually identified as a coronavirus and designated Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV has now been reported in more than 27 countries across the Middle East, Europe, North Africa and Asia. As of July 2017, 2040 MERS-CoV laboratory confirmed cases, resulting in 712 deaths, were reported globally, with a majority of these cases from the Arabian Peninsula. This review summarises the current understanding of MERS-CoV, with special reference to the (i) genome structure; (ii) clinical features; (iii) diagnosis of infection; and (iv) treatment and vaccine development.

Authors+Show Affiliations

Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Robert Sobukwe Drive, Bellville 7535, South Africa. achafekar@uwc.ac.za.Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Robert Sobukwe Drive, Bellville 7535, South Africa. bfielding@uwc.ac.za.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29495250

Citation

Chafekar, Aasiyah, and Burtram C. Fielding. "MERS-CoV: Understanding the Latest Human Coronavirus Threat." Viruses, vol. 10, no. 2, 2018.
Chafekar A, Fielding BC. MERS-CoV: Understanding the Latest Human Coronavirus Threat. Viruses. 2018;10(2).
Chafekar, A., & Fielding, B. C. (2018). MERS-CoV: Understanding the Latest Human Coronavirus Threat. Viruses, 10(2). https://doi.org/10.3390/v10020093
Chafekar A, Fielding BC. MERS-CoV: Understanding the Latest Human Coronavirus Threat. Viruses. 2018 02 24;10(2) PubMed PMID: 29495250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MERS-CoV: Understanding the Latest Human Coronavirus Threat. AU - Chafekar,Aasiyah, AU - Fielding,Burtram C, Y1 - 2018/02/24/ PY - 2017/11/29/received PY - 2018/01/28/revised PY - 2018/02/02/accepted PY - 2018/3/3/entrez PY - 2018/3/3/pubmed PY - 2018/11/28/medline KW - MERS-CoV KW - clinical features KW - human coronavirus KW - lower respiratory tract infections KW - respiratory viruses KW - upper respiratory tract infections JF - Viruses JO - Viruses VL - 10 IS - 2 N2 - Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi Arabia. The aetiological agent was eventually identified as a coronavirus and designated Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV has now been reported in more than 27 countries across the Middle East, Europe, North Africa and Asia. As of July 2017, 2040 MERS-CoV laboratory confirmed cases, resulting in 712 deaths, were reported globally, with a majority of these cases from the Arabian Peninsula. This review summarises the current understanding of MERS-CoV, with special reference to the (i) genome structure; (ii) clinical features; (iii) diagnosis of infection; and (iv) treatment and vaccine development. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/29495250/MERS_CoV:_Understanding_the_Latest_Human_Coronavirus_Threat_ L2 - https://www.mdpi.com/resolver?pii=v10020093 DB - PRIME DP - Unbound Medicine ER -