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Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases.
Molecules. 2018 Feb 25; 23(3)M

Abstract

As the population ages, neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD) impose a heavy burden on society and families. The pathogeneses of PD and AD are complex. There are no radical cures for the diseases, and existing therapeutic agents for PD and AD have diverse side effects. Tea contains many bioactive components such as polyphenols, theanine, caffeine, and theaflavins. Some investigations of epidemiology have demonstrated that drinking tea can decrease the risk of PD and AD. Tea polyphenols can lower the morbidity of PD and AD by reducing oxidative stress and regulating signaling pathways and metal chelation. Theanine can inhibit the glutamate receptors and regulate the extracellular concentration of glutamine, presenting neuroprotective effects. Additionally, the neuroprotective mechanisms of caffeine and theaflavins may contribute to the ability to antagonize the adenosine receptor A2AR and the antioxidant properties, respectively. Thus, tea bioactive components might be useful for neuronal degeneration treatment in the future. In the present paper, the neuro protection and the mechanisms of tea and its bioactive components are reviewed. Moreover, the potential challenges and future work are also discussed.

Authors+Show Affiliations

Tea Research Institute, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. 21516096@zju.edu.cn.Tea Research Institute, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. fdlete@126.com.Tea Research Institute, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. 21516098@zju.edu.cn.Tea Research Institute, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. 21516111@zju.edu.cn.Tea Research Institute, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. jllu@zju.edu.cn.Tea Research Institute, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. yrliang@zju.edu.cn.Tea Research Institute, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. xqzheng@zju.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29495349

Citation

Chen, Shu-Qing, et al. "Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases." Molecules (Basel, Switzerland), vol. 23, no. 3, 2018.
Chen SQ, Wang ZS, Ma YX, et al. Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases. Molecules. 2018;23(3).
Chen, S. Q., Wang, Z. S., Ma, Y. X., Zhang, W., Lu, J. L., Liang, Y. R., & Zheng, X. Q. (2018). Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases. Molecules (Basel, Switzerland), 23(3). https://doi.org/10.3390/molecules23030512
Chen SQ, et al. Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases. Molecules. 2018 Feb 25;23(3) PubMed PMID: 29495349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases. AU - Chen,Shu-Qing, AU - Wang,Ze-Shi, AU - Ma,Yi-Xiao, AU - Zhang,Wei, AU - Lu,Jian-Liang, AU - Liang,Yue-Rong, AU - Zheng,Xin-Qiang, Y1 - 2018/02/25/ PY - 2018/01/18/received PY - 2018/02/23/revised PY - 2018/02/23/accepted PY - 2018/3/3/entrez PY - 2018/3/3/pubmed PY - 2018/8/28/medline KW - Alzheimer’s disease KW - Parkinson’s disease KW - caffeine KW - neuronal degeneration KW - polyphenols KW - theaflavins KW - theanine JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 3 N2 - As the population ages, neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD) impose a heavy burden on society and families. The pathogeneses of PD and AD are complex. There are no radical cures for the diseases, and existing therapeutic agents for PD and AD have diverse side effects. Tea contains many bioactive components such as polyphenols, theanine, caffeine, and theaflavins. Some investigations of epidemiology have demonstrated that drinking tea can decrease the risk of PD and AD. Tea polyphenols can lower the morbidity of PD and AD by reducing oxidative stress and regulating signaling pathways and metal chelation. Theanine can inhibit the glutamate receptors and regulate the extracellular concentration of glutamine, presenting neuroprotective effects. Additionally, the neuroprotective mechanisms of caffeine and theaflavins may contribute to the ability to antagonize the adenosine receptor A2AR and the antioxidant properties, respectively. Thus, tea bioactive components might be useful for neuronal degeneration treatment in the future. In the present paper, the neuro protection and the mechanisms of tea and its bioactive components are reviewed. Moreover, the potential challenges and future work are also discussed. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/29495349/Neuroprotective_Effects_and_Mechanisms_of_Tea_Bioactive_Components_in_Neurodegenerative_Diseases_ L2 - https://www.mdpi.com/resolver?pii=molecules23030512 DB - PRIME DP - Unbound Medicine ER -