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Melatonin: A Versatile Protector against Oxidative DNA Damage.
Molecules. 2018 Feb 27; 23(3)M

Abstract

Oxidative damage to DNA has important implications for human health and has been identified as a key factor in the onset and development of numerous diseases. Thus, it is evident that preventing DNA from oxidative damage is crucial for humans and for any living organism. Melatonin is an astonishingly versatile molecule in this context. It can offer both direct and indirect protection against a wide variety of damaging agents and through multiple pathways, which may (or may not) take place simultaneously. They include direct antioxidative protection, which is mediated by melatonin's free radical scavenging activity, and also indirect ways of action. The latter include, at least: (i) inhibition of metal-induced DNA damage; (ii) protection against non-radical triggers of oxidative DNA damage; (iii) continuous protection after being metabolized; (iv) activation of antioxidative enzymes; (v) inhibition of pro-oxidative enzymes; and (vi) boosting of the DNA repair machinery. The rather unique capability of melatonin to exhibit multiple neutralizing actions against diverse threatening factors, together with its low toxicity and its ability to cross biological barriers, are all significant to its efficiency for preventing oxidative damage to DNA.

Authors+Show Affiliations

Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, C. P. 09340, Mexico D. F. Mexico. agalano@prodigy.net.mx.Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA. tan@uthscsa.edu.Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA. reiter@uthscsa.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29495460

Citation

Galano, Annia, et al. "Melatonin: a Versatile Protector Against Oxidative DNA Damage." Molecules (Basel, Switzerland), vol. 23, no. 3, 2018.
Galano A, Tan DX, Reiter RJ. Melatonin: A Versatile Protector against Oxidative DNA Damage. Molecules. 2018;23(3).
Galano, A., Tan, D. X., & Reiter, R. J. (2018). Melatonin: A Versatile Protector against Oxidative DNA Damage. Molecules (Basel, Switzerland), 23(3). https://doi.org/10.3390/molecules23030530
Galano A, Tan DX, Reiter RJ. Melatonin: a Versatile Protector Against Oxidative DNA Damage. Molecules. 2018 Feb 27;23(3) PubMed PMID: 29495460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin: A Versatile Protector against Oxidative DNA Damage. AU - Galano,Annia, AU - Tan,Dun-Xian, AU - Reiter,Russel J, Y1 - 2018/02/27/ PY - 2018/01/25/received PY - 2018/02/13/revised PY - 2018/02/22/accepted PY - 2018/3/3/entrez PY - 2018/3/3/pubmed PY - 2018/8/28/medline KW - antioxidant activity KW - antioxidative mechanisms KW - antioxidative protection KW - free radical scavenger KW - metal chelation JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 3 N2 - Oxidative damage to DNA has important implications for human health and has been identified as a key factor in the onset and development of numerous diseases. Thus, it is evident that preventing DNA from oxidative damage is crucial for humans and for any living organism. Melatonin is an astonishingly versatile molecule in this context. It can offer both direct and indirect protection against a wide variety of damaging agents and through multiple pathways, which may (or may not) take place simultaneously. They include direct antioxidative protection, which is mediated by melatonin's free radical scavenging activity, and also indirect ways of action. The latter include, at least: (i) inhibition of metal-induced DNA damage; (ii) protection against non-radical triggers of oxidative DNA damage; (iii) continuous protection after being metabolized; (iv) activation of antioxidative enzymes; (v) inhibition of pro-oxidative enzymes; and (vi) boosting of the DNA repair machinery. The rather unique capability of melatonin to exhibit multiple neutralizing actions against diverse threatening factors, together with its low toxicity and its ability to cross biological barriers, are all significant to its efficiency for preventing oxidative damage to DNA. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/29495460/Melatonin:_A_Versatile_Protector_against_Oxidative_DNA_Damage_ DB - PRIME DP - Unbound Medicine ER -