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Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study.
Br J Nutr. 2018 02; 119(4):442-455.BJ

Abstract

Previous studies show associations between dairy product consumption and type 2 diabetes, but only a few studies conducted detailed analyses for a variety of dairy subgroups. Therefore, we examined cross-sectional associations of a broad variety of dairy subgroups with pre-diabetes and newly diagnosed type 2 diabetes (ND-T2DM) among Dutch adults. In total, 112 086 adults without diabetes completed a semi-quantitative FFQ and donated blood. Pre-diabetes was defined as fasting plasma glucose (FPG) between 5·6 and 6·9 mmol/l or HbA1c% of 5·7-6·4 %. ND-T2DM was defined as FPG ≥7·0 mmol/l or HbA1c ≥6·5 %. Logistic regression analyses were conducted by 100 g or serving increase and dairy tertiles (T1ref), while adjusting for demographic, lifestyle and dietary covariates. Median dairy product intake was 324 (interquartile range 227) g/d; 25 549 (23 %) participants had pre-diabetes; and 1305 (1 %) had ND-T2DM. After full adjustment, inverse associations were observed of skimmed dairy (OR100 g 0·98; 95 % CI 0·97, 1·00), fermented dairy (OR100 g 0·98; 95 % CI 0·97, 0·99) and buttermilk (OR150 g 0·97; 95 % CI 0·94, 1·00) with pre-diabetes. Positive associations were observed for full-fat dairy (OR100 g 1·003; 95 % CI 1·01, 1·06), non-fermented dairy products (OR100 g 1·01; 95 % CI 1·00, 1·02) and custard (ORserving/150 g 1·13; 95 % CI 1·03, 1·24) with pre-diabetes. Moreover, full-fat dairy products (ORT3 1·16; 95 % CI 0·99, 1·35), non-fermented dairy products (OR100 g 1·05; 95 % CI 1·01, 1·09) and milk (ORserving/150 g 1·08; 95 % CI 1·02, 1·15) were positively associated with ND-T2DM. In conclusion, our data showed inverse associations of skimmed and fermented dairy products with pre-diabetes. Positive associations were observed for full-fat and non-fermented dairy products with pre-diabetes and ND-T2DM.

Authors+Show Affiliations

1Division of Human Nutrition,Wageningen University,6700 AA Wageningen,The Netherlands.1Division of Human Nutrition,Wageningen University,6700 AA Wageningen,The Netherlands.2FrieslandCampina,3800 BN Amersfoort,The Netherlands.1Division of Human Nutrition,Wageningen University,6700 AA Wageningen,The Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29498341

Citation

Brouwer-Brolsma, Elske M., et al. "Dairy Product Consumption Is Associated With Pre-diabetes and Newly Diagnosed Type 2 Diabetes in the Lifelines Cohort Study." The British Journal of Nutrition, vol. 119, no. 4, 2018, pp. 442-455.
Brouwer-Brolsma EM, Sluik D, Singh-Povel CM, et al. Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study. Br J Nutr. 2018;119(4):442-455.
Brouwer-Brolsma, E. M., Sluik, D., Singh-Povel, C. M., & Feskens, E. J. M. (2018). Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study. The British Journal of Nutrition, 119(4), 442-455. https://doi.org/10.1017/S0007114517003762
Brouwer-Brolsma EM, et al. Dairy Product Consumption Is Associated With Pre-diabetes and Newly Diagnosed Type 2 Diabetes in the Lifelines Cohort Study. Br J Nutr. 2018;119(4):442-455. PubMed PMID: 29498341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study. AU - Brouwer-Brolsma,Elske M, AU - Sluik,Diewertje, AU - Singh-Povel,Cecile M, AU - Feskens,Edith J M, PY - 2018/3/3/entrez PY - 2018/3/3/pubmed PY - 2019/2/12/medline KW - FPG fasting plasma glucose KW - ND-T2DM newly diagnosed type 2 diabetes KW - T2DM type 2 diabetes KW - Cohorts KW - Dairy products KW - Diabetes KW - Fermentation KW - Glucose SP - 442 EP - 455 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 119 IS - 4 N2 - Previous studies show associations between dairy product consumption and type 2 diabetes, but only a few studies conducted detailed analyses for a variety of dairy subgroups. Therefore, we examined cross-sectional associations of a broad variety of dairy subgroups with pre-diabetes and newly diagnosed type 2 diabetes (ND-T2DM) among Dutch adults. In total, 112 086 adults without diabetes completed a semi-quantitative FFQ and donated blood. Pre-diabetes was defined as fasting plasma glucose (FPG) between 5·6 and 6·9 mmol/l or HbA1c% of 5·7-6·4 %. ND-T2DM was defined as FPG ≥7·0 mmol/l or HbA1c ≥6·5 %. Logistic regression analyses were conducted by 100 g or serving increase and dairy tertiles (T1ref), while adjusting for demographic, lifestyle and dietary covariates. Median dairy product intake was 324 (interquartile range 227) g/d; 25 549 (23 %) participants had pre-diabetes; and 1305 (1 %) had ND-T2DM. After full adjustment, inverse associations were observed of skimmed dairy (OR100 g 0·98; 95 % CI 0·97, 1·00), fermented dairy (OR100 g 0·98; 95 % CI 0·97, 0·99) and buttermilk (OR150 g 0·97; 95 % CI 0·94, 1·00) with pre-diabetes. Positive associations were observed for full-fat dairy (OR100 g 1·003; 95 % CI 1·01, 1·06), non-fermented dairy products (OR100 g 1·01; 95 % CI 1·00, 1·02) and custard (ORserving/150 g 1·13; 95 % CI 1·03, 1·24) with pre-diabetes. Moreover, full-fat dairy products (ORT3 1·16; 95 % CI 0·99, 1·35), non-fermented dairy products (OR100 g 1·05; 95 % CI 1·01, 1·09) and milk (ORserving/150 g 1·08; 95 % CI 1·02, 1·15) were positively associated with ND-T2DM. In conclusion, our data showed inverse associations of skimmed and fermented dairy products with pre-diabetes. Positive associations were observed for full-fat and non-fermented dairy products with pre-diabetes and ND-T2DM. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/29498341/Dairy_product_consumption_is_associated_with_pre_diabetes_and_newly_diagnosed_type_2_diabetes_in_the_Lifelines_Cohort_Study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517003762/type/journal_article DB - PRIME DP - Unbound Medicine ER -