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Effect of increased calcium consumption from fat-free milk in an energy-restricted diet on the metabolic syndrome and cardiometabolic outcomes in adults with type 2 diabetes mellitus: a randomised cross-over clinical trial.
Br J Nutr. 2018 02; 119(4):422-430.BJ

Abstract

We investigated the effects of high-Ca fat-free milk phase (MD) (prescription of approximately 1500 mg of Ca/d) v. low-Ca phase (CD) (prescription of approximately 800 mg of Ca/d) in an energy-restricted diet on the metabolic syndrome (MetS) and cardiometabolic measures in individuals with type 2 diabetes mellitus (T2DM) and low habitual Ca consumption (<600 mg/d). In this randomised cross-over design, fourteen adults with T2DM (49·5 (sd 8·6) years, BMI 29·4 (sd 4·5) kg/m2) consumed either MD or CD for 12 weeks, with a washout of 18 weeks between phases. A breakfast shake containing 700 mg (MD) or 6·4 mg (CD) of Ca was consumed in the laboratory. In addition, energy-restricted diets were prescribed (800 mg of dietary Ca/d). Waist circumference (WC), fasting glucose, fasting TAG, systolic (SBP) and diastolic blood pressure (DBP), fasting total cholesterol, fasting LDL-cholesterol, fasting HDL-cholesterol, HDL:LDL ratio, HDL:TAG ratio and lipid accumulation product (LAP) index were assessed at baseline and after each phase. Ca consumption during the study was equivalent to 1200 mg/d during MD and 525 mg/d during CD. There was a greater reduction in WC, SBP, DBP and LAP index after MD compared with CD. HDL:LDL ratio increased and total cholesterol, LDL-cholesterol, SBP, DBP and LAP index decreased only in MD. The consumption of approximately 1200 mg of Ca/d (700 mg from fat-free milk+500mg from other dietary sources) associated with an energy-restricted diet decreased some of the MetS components and cardiometabolic measures in adults with T2DM.

Authors+Show Affiliations

1Instituto Federal do Sudeste de Minas Gerais - Campus Barbacena,Rua Monsenhor José Augusto,204,Bairro São José,Barbacena,Minas Gerais,CEP 36205-018,Brazil.2Nutrition and Health Department,Federal University of Viçosa (Universidade Federal de Viçosa),Avenida PH Rolfs,s/n,Viçosa,Minas Gerais,CEP 36570-000,Brazil.2Nutrition and Health Department,Federal University of Viçosa (Universidade Federal de Viçosa),Avenida PH Rolfs,s/n,Viçosa,Minas Gerais,CEP 36570-000,Brazil.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29498351

Citation

Gomes, Junia M G., et al. "Effect of Increased Calcium Consumption From Fat-free Milk in an Energy-restricted Diet On the Metabolic Syndrome and Cardiometabolic Outcomes in Adults With Type 2 Diabetes Mellitus: a Randomised Cross-over Clinical Trial." The British Journal of Nutrition, vol. 119, no. 4, 2018, pp. 422-430.
Gomes JMG, Costa JDA, Alfenas RCG. Effect of increased calcium consumption from fat-free milk in an energy-restricted diet on the metabolic syndrome and cardiometabolic outcomes in adults with type 2 diabetes mellitus: a randomised cross-over clinical trial. Br J Nutr. 2018;119(4):422-430.
Gomes, J. M. G., Costa, J. D. A., & Alfenas, R. C. G. (2018). Effect of increased calcium consumption from fat-free milk in an energy-restricted diet on the metabolic syndrome and cardiometabolic outcomes in adults with type 2 diabetes mellitus: a randomised cross-over clinical trial. The British Journal of Nutrition, 119(4), 422-430. https://doi.org/10.1017/S0007114517003956
Gomes JMG, Costa JDA, Alfenas RCG. Effect of Increased Calcium Consumption From Fat-free Milk in an Energy-restricted Diet On the Metabolic Syndrome and Cardiometabolic Outcomes in Adults With Type 2 Diabetes Mellitus: a Randomised Cross-over Clinical Trial. Br J Nutr. 2018;119(4):422-430. PubMed PMID: 29498351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of increased calcium consumption from fat-free milk in an energy-restricted diet on the metabolic syndrome and cardiometabolic outcomes in adults with type 2 diabetes mellitus: a randomised cross-over clinical trial. AU - Gomes,Junia M G, AU - Costa,Jorge D A, AU - Alfenas,Rita C G, PY - 2018/3/3/entrez PY - 2018/3/3/pubmed PY - 2019/2/12/medline KW - BP blood pressure KW - CD low-calcium phase KW - DBP diastolic blood pressure KW - LAP lipid accumulation product KW - MD high-calcium fat-free milk phase KW - MET metabolic equivalents of task KW - MetS metabolic syndrome KW - PAL KW - PTH KW - RCT randomised clinical trials KW - SBP systolic blood pressure KW - T2DM type 2 diabetes mellitus KW - WC waist circumference KW - parathyroid hormone KW - physical activity levels KW - Blood pressure KW - CVD KW - Calcium KW - Dairy products KW - Diets KW - Lipids KW - Metabolic syndrome SP - 422 EP - 430 JF - The British journal of nutrition JO - Br J Nutr VL - 119 IS - 4 N2 - We investigated the effects of high-Ca fat-free milk phase (MD) (prescription of approximately 1500 mg of Ca/d) v. low-Ca phase (CD) (prescription of approximately 800 mg of Ca/d) in an energy-restricted diet on the metabolic syndrome (MetS) and cardiometabolic measures in individuals with type 2 diabetes mellitus (T2DM) and low habitual Ca consumption (<600 mg/d). In this randomised cross-over design, fourteen adults with T2DM (49·5 (sd 8·6) years, BMI 29·4 (sd 4·5) kg/m2) consumed either MD or CD for 12 weeks, with a washout of 18 weeks between phases. A breakfast shake containing 700 mg (MD) or 6·4 mg (CD) of Ca was consumed in the laboratory. In addition, energy-restricted diets were prescribed (800 mg of dietary Ca/d). Waist circumference (WC), fasting glucose, fasting TAG, systolic (SBP) and diastolic blood pressure (DBP), fasting total cholesterol, fasting LDL-cholesterol, fasting HDL-cholesterol, HDL:LDL ratio, HDL:TAG ratio and lipid accumulation product (LAP) index were assessed at baseline and after each phase. Ca consumption during the study was equivalent to 1200 mg/d during MD and 525 mg/d during CD. There was a greater reduction in WC, SBP, DBP and LAP index after MD compared with CD. HDL:LDL ratio increased and total cholesterol, LDL-cholesterol, SBP, DBP and LAP index decreased only in MD. The consumption of approximately 1200 mg of Ca/d (700 mg from fat-free milk+500mg from other dietary sources) associated with an energy-restricted diet decreased some of the MetS components and cardiometabolic measures in adults with T2DM. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/29498351/Effect_of_increased_calcium_consumption_from_fat_free_milk_in_an_energy_restricted_diet_on_the_metabolic_syndrome_and_cardiometabolic_outcomes_in_adults_with_type_2_diabetes_mellitus:_a_randomised_cross_over_clinical_trial_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517003956/type/journal_article DB - PRIME DP - Unbound Medicine ER -