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Investigation of the tableting behavior of Ibuprofen DC 85 W.
Drug Dev Ind Pharm. 2018 Aug; 44(8):1262-1272.DD

Abstract

The aim of the present study was to investigate the tableting behavior of Ibuprofen DC 85 W with special focus on the tablet disintegration time, the tablet crushing strength, and the sticking tendency to punch surfaces. To simulate production conditions, tableting was conducted on a rotary press, equipped with three compaction stations. An I-optimal design of experiments was used to analyze the influence of the pre-compaction, the intermediate compaction, and the main compaction force on the two responses: tablet disintegration time and crushing strength. It was shown that Ibuprofen DC 85 W showed a good tableting behavior with regard to both responses. The tablet disintegration was considerably affected by the maximum compaction force applied, but was also slightly affected by preceding compaction events. The tablet crushing strength was mainly affected by the maximum applied compaction force independent of the order of these forces. The sticking tendency of Ibuprofen DC 85 W was compared with that two other ibuprofen powder formulations in long-term tableting runs. Compared to the other two formulations, sticking was considerably lower with Ibuprofen DC 85 W. The sticking tendency was not influenced by the addition of an intermediate compaction force, but was remarkably reduced by the choice of the punch tip coating.

Authors+Show Affiliations

a Division of Pharmaceutical Technology, Department of Chemistry , University of Hamburg , Hamburg , Germany.b European Application Lab (Pharma Solutions & Human Nutrition) , BASF SE , Ludwigshafen , Germany.b European Application Lab (Pharma Solutions & Human Nutrition) , BASF SE , Ludwigshafen , Germany.a Division of Pharmaceutical Technology, Department of Chemistry , University of Hamburg , Hamburg , Germany.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29499616

Citation

Al-Karawi, Claudia, et al. "Investigation of the Tableting Behavior of Ibuprofen DC 85 W." Drug Development and Industrial Pharmacy, vol. 44, no. 8, 2018, pp. 1262-1272.
Al-Karawi C, Cech T, Bang F, et al. Investigation of the tableting behavior of Ibuprofen DC 85 W. Drug Dev Ind Pharm. 2018;44(8):1262-1272.
Al-Karawi, C., Cech, T., Bang, F., & Leopold, C. S. (2018). Investigation of the tableting behavior of Ibuprofen DC 85 W. Drug Development and Industrial Pharmacy, 44(8), 1262-1272. https://doi.org/10.1080/03639045.2018.1442846
Al-Karawi C, et al. Investigation of the Tableting Behavior of Ibuprofen DC 85 W. Drug Dev Ind Pharm. 2018;44(8):1262-1272. PubMed PMID: 29499616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of the tableting behavior of Ibuprofen DC 85 W. AU - Al-Karawi,Claudia, AU - Cech,Thorsten, AU - Bang,Florian, AU - Leopold,Claudia S, Y1 - 2018/03/22/ PY - 2018/3/4/pubmed PY - 2018/10/12/medline PY - 2018/3/4/entrez KW - DoE KW - Tableting KW - crushing strength KW - disintegration time KW - ibuprofen KW - multiple compaction KW - punch coating KW - sticking SP - 1262 EP - 1272 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 44 IS - 8 N2 - The aim of the present study was to investigate the tableting behavior of Ibuprofen DC 85 W with special focus on the tablet disintegration time, the tablet crushing strength, and the sticking tendency to punch surfaces. To simulate production conditions, tableting was conducted on a rotary press, equipped with three compaction stations. An I-optimal design of experiments was used to analyze the influence of the pre-compaction, the intermediate compaction, and the main compaction force on the two responses: tablet disintegration time and crushing strength. It was shown that Ibuprofen DC 85 W showed a good tableting behavior with regard to both responses. The tablet disintegration was considerably affected by the maximum compaction force applied, but was also slightly affected by preceding compaction events. The tablet crushing strength was mainly affected by the maximum applied compaction force independent of the order of these forces. The sticking tendency of Ibuprofen DC 85 W was compared with that two other ibuprofen powder formulations in long-term tableting runs. Compared to the other two formulations, sticking was considerably lower with Ibuprofen DC 85 W. The sticking tendency was not influenced by the addition of an intermediate compaction force, but was remarkably reduced by the choice of the punch tip coating. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/29499616/Investigation_of_the_tableting_behavior_of_Ibuprofen_DC_85_W_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639045.2018.1442846 DB - PRIME DP - Unbound Medicine ER -