Tags

Type your tag names separated by a space and hit enter

Changes in salivary chromogranin A levels in adults with atopic dermatitis are correlated with changes in their condition.
J Dermatol. 2018 May; 45(5):554-559.JD

Abstract

Stress-induced scratching is an issue in patients with adult atopic dermatitis (AD). Symptoms of stress-induced AD are common in clinical practise. Salivary chromogranin A (CgA) level has research value as a possible index related to a patient's psychological stress. Using saliva, which is easily collectable, we compared two assessments of the severities of AD and stress with the levels of stress proteins in the saliva of 30 patients with AD in the Department of Dermatology of Shimane University between April 2015 and May 2017. The severities of AD and stress were assessed using the Scoring Atopic Dermatitis (SCORAD) score and State-Trait Anxiety Inventory score, respectively. Additionally, the assessments included those of personality using the Tokyo University Egogram (TEG)-II score and quality of life using the Dermatology Life Quality Index score. Simultaneously, we measured their salivary CgA levels. The change in salivary CgA per protein in patients with AD was correlated with their changes in SCORAD score (correlation coefficient, r = 0.596, P = 0.001) and objective SCORAD (r = 0.608, P < 0.001). The changes in CgA per protein correlated with those in TEG-II A (r = 0.370, P = 0.022), while the changes in SCORAD score correlated with those in DLQI (r = 0.309, P = 0.048). Our results suggest that changes in a patient's condition are reflective of the changes in the patient's stress. The changes in salivary CgA level in patients with AD correlated with the changes in their condition.

Authors+Show Affiliations

Department of Dermatology, Faculty of Medicine, Shimane University, Izumo, Japan.Department of Dermatology, Faculty of Medicine, Shimane University, Izumo, Japan.Department of Dermatology, Faculty of Medicine, Shimane University, Izumo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29500830

Citation

Cai, Liang, et al. "Changes in Salivary Chromogranin a Levels in Adults With Atopic Dermatitis Are Correlated With Changes in Their Condition." The Journal of Dermatology, vol. 45, no. 5, 2018, pp. 554-559.
Cai L, Kaneko S, Morita E. Changes in salivary chromogranin A levels in adults with atopic dermatitis are correlated with changes in their condition. J Dermatol. 2018;45(5):554-559.
Cai, L., Kaneko, S., & Morita, E. (2018). Changes in salivary chromogranin A levels in adults with atopic dermatitis are correlated with changes in their condition. The Journal of Dermatology, 45(5), 554-559. https://doi.org/10.1111/1346-8138.14277
Cai L, Kaneko S, Morita E. Changes in Salivary Chromogranin a Levels in Adults With Atopic Dermatitis Are Correlated With Changes in Their Condition. J Dermatol. 2018;45(5):554-559. PubMed PMID: 29500830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in salivary chromogranin A levels in adults with atopic dermatitis are correlated with changes in their condition. AU - Cai,Liang, AU - Kaneko,Sakae, AU - Morita,Eishin, Y1 - 2018/03/03/ PY - 2017/12/14/received PY - 2018/01/29/accepted PY - 2018/3/4/pubmed PY - 2018/9/25/medline PY - 2018/3/4/entrez KW - atopic dermatitis KW - chromogranin A KW - disease severity KW - saliva KW - stress marker SP - 554 EP - 559 JF - The Journal of dermatology JO - J. Dermatol. VL - 45 IS - 5 N2 - Stress-induced scratching is an issue in patients with adult atopic dermatitis (AD). Symptoms of stress-induced AD are common in clinical practise. Salivary chromogranin A (CgA) level has research value as a possible index related to a patient's psychological stress. Using saliva, which is easily collectable, we compared two assessments of the severities of AD and stress with the levels of stress proteins in the saliva of 30 patients with AD in the Department of Dermatology of Shimane University between April 2015 and May 2017. The severities of AD and stress were assessed using the Scoring Atopic Dermatitis (SCORAD) score and State-Trait Anxiety Inventory score, respectively. Additionally, the assessments included those of personality using the Tokyo University Egogram (TEG)-II score and quality of life using the Dermatology Life Quality Index score. Simultaneously, we measured their salivary CgA levels. The change in salivary CgA per protein in patients with AD was correlated with their changes in SCORAD score (correlation coefficient, r = 0.596, P = 0.001) and objective SCORAD (r = 0.608, P < 0.001). The changes in CgA per protein correlated with those in TEG-II A (r = 0.370, P = 0.022), while the changes in SCORAD score correlated with those in DLQI (r = 0.309, P = 0.048). Our results suggest that changes in a patient's condition are reflective of the changes in the patient's stress. The changes in salivary CgA level in patients with AD correlated with the changes in their condition. SN - 1346-8138 UR - https://www.unboundmedicine.com/medline/citation/29500830/Changes_in_salivary_chromogranin_A_levels_in_adults_with_atopic_dermatitis_are_correlated_with_changes_in_their_condition_ L2 - https://doi.org/10.1111/1346-8138.14277 DB - PRIME DP - Unbound Medicine ER -