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Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers.
Drug Alcohol Depend 2018; 185:351-355DA

Abstract

BACKGROUND

Previous research demonstrated that urinary ethanol concentrations were significantly lower in hangover resistant individuals compared to drinkers who reported having a hangover. This finding suggests that the rate of ethanol metabolism is faster in drinkers who do not experience an alcohol hangover. This study aimed to directly compare alcohol metabolism after administering a low dose of ethanol to hangover sensitive drinkers and hangover resistant drinkers.

METHODS

Social drinkers who previously participated in hangover trials at Utrecht University were invited to participate. It was aimed to include 12 hangover resistant drinkers and 12 hangover sensitive drinkers. Participants consumed alcohol to reach a breath alcohol concentration (BrAC) of 0.05%. Every 5 min BrAC was determined, until BrAC reached zero. Every 15 min, the Karolinska Sleeping Scale (KSS) was administered to assess subjective sleepiness, and subjective intoxication was measured.

RESULTS

Data of N = 23 participants with a mean age of 22.4 (±1.9) years was included in the analyses. No significant difference in BrAC over time was found between the hangover resistant group and the hangover sensitive group. In line, subjective sleepiness scores and subjective intoxication ratings did not significantly differ between the groups at any point in time after alcohol consumption.

CONCLUSION

Hangover resistant individuals and hangover sensitive drinkers did not significantly differ on BrAC, subjective sleepiness, and subjective intoxication after consuming a moderate amount of alcohol. These findings suggest that drinkers who usually experience hangovers after a heavy drinking occasion do not experience alcohol intoxication differently than hangover resistant drinkers.

Authors+Show Affiliations

Division of Pharmacology, Utrecht University, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands; Nutricia Research, Utrecht, The Netherlands.Groningen University, Groningen, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands; Centre for Human Psychopharmacology, Swinburne University, Melbourne, Australia. Electronic address: j.c.verster@uu.nl.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29500954

Citation

Mackus, M, et al. "Alcohol Metabolism in Hangover Sensitive Versus Hangover Resistant Social Drinkers." Drug and Alcohol Dependence, vol. 185, 2018, pp. 351-355.
Mackus M, van Schrojenstein Lantman M, Van de Loo AJAE, et al. Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers. Drug Alcohol Depend. 2018;185:351-355.
Mackus, M., van Schrojenstein Lantman, M., Van de Loo, A. J. A. E., Kraneveld, A. D., Garssen, J., Brookhuis, K. A., & Verster, J. C. (2018). Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers. Drug and Alcohol Dependence, 185, pp. 351-355. doi:10.1016/j.drugalcdep.2017.11.040.
Mackus M, et al. Alcohol Metabolism in Hangover Sensitive Versus Hangover Resistant Social Drinkers. Drug Alcohol Depend. 2018 04 1;185:351-355. PubMed PMID: 29500954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers. AU - Mackus,M, AU - van Schrojenstein Lantman,M, AU - Van de Loo,A J A E, AU - Kraneveld,A D, AU - Garssen,J, AU - Brookhuis,K A, AU - Verster,J C, Y1 - 2018/02/21/ PY - 2017/09/14/received PY - 2017/11/17/revised PY - 2017/11/20/accepted PY - 2018/3/4/pubmed PY - 2018/9/21/medline PY - 2018/3/4/entrez KW - Alcohol KW - Breath alcohol concentration KW - Hangover KW - Metabolism KW - Sleepiness KW - Subjective intoxication SP - 351 EP - 355 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 185 N2 - BACKGROUND: Previous research demonstrated that urinary ethanol concentrations were significantly lower in hangover resistant individuals compared to drinkers who reported having a hangover. This finding suggests that the rate of ethanol metabolism is faster in drinkers who do not experience an alcohol hangover. This study aimed to directly compare alcohol metabolism after administering a low dose of ethanol to hangover sensitive drinkers and hangover resistant drinkers. METHODS: Social drinkers who previously participated in hangover trials at Utrecht University were invited to participate. It was aimed to include 12 hangover resistant drinkers and 12 hangover sensitive drinkers. Participants consumed alcohol to reach a breath alcohol concentration (BrAC) of 0.05%. Every 5 min BrAC was determined, until BrAC reached zero. Every 15 min, the Karolinska Sleeping Scale (KSS) was administered to assess subjective sleepiness, and subjective intoxication was measured. RESULTS: Data of N = 23 participants with a mean age of 22.4 (±1.9) years was included in the analyses. No significant difference in BrAC over time was found between the hangover resistant group and the hangover sensitive group. In line, subjective sleepiness scores and subjective intoxication ratings did not significantly differ between the groups at any point in time after alcohol consumption. CONCLUSION: Hangover resistant individuals and hangover sensitive drinkers did not significantly differ on BrAC, subjective sleepiness, and subjective intoxication after consuming a moderate amount of alcohol. These findings suggest that drinkers who usually experience hangovers after a heavy drinking occasion do not experience alcohol intoxication differently than hangover resistant drinkers. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/29500954/Alcohol_metabolism_in_hangover_sensitive_versus_hangover_resistant_social_drinkers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(18)30069-3 DB - PRIME DP - Unbound Medicine ER -