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[Relationships between the enrichment of ETBF, Fn, Hp in intestinal and colorectal cancer].
Zhonghua Zhong Liu Za Zhi. 2018 Feb 23; 40(2):99-104.ZZ

Abstract

Objective:

To explore relationships between the enrichment of ETBF, Fn, Hp in feces, tissues and colorectal cancer.

Methods:

Feces, lesion tissue and adjacent tissue from 24 patients with colorectal cancer and 31 patients with adenomas were collected, and we collected Feces and tissue of 20 healthy control persons. Then the copy numbers of enterotoxigenic B. fragilis (ETBF), Fusobacterium nucleatum (Fn) and Helicobacter pylori (Hp) were determined by quantitative real-time PCR. Immunohistochemical method was used to examine the expression intensity of EGFR and p53, and the relationships between different expression intensity of EGFR, p53 and the numbers of three bacterias.

Results:

In the feces, copy numbers of ETBF and Fn were as follous: colorectal cancer group>adenomas group>healthy control group (P<0.05). Copy numbers of Hp were as follous: colorectal cancer group>healthy control group (P<0.01); adenomas group>healthy control group (P<0.01). In the tissue, copy numbers of ETBF, Fn were as follows: colorectal cancer group>adenomas group>healthy control group (P<0.05). Copy numbers of Hp were as follows: colorectal cancer group>healthy control group (P<0.01); adenomas group>healthy control group (P<0.01). Copy numbers of those three bacteria in the lesion tissue and the adjacent tissue had no significant difference. This happened both in colorectal cancer group and adenomas group. The different expression intensity of EGFR, p53 and the number of three bacteria showed no obviously statistical correlation(P>0.05).

Conclusion:

Adenomatous polyp and colorectal cancer patients show high enrichment of ETBF, Fn and Hp in both feces and tissues. ETBF, Fn and Hp probably contribute to the development of adenomatous polyp and colorectal cancer. Trial registration Chinese Clinical Trial Registry, ChiCTR-BOC-17012509.

Authors+Show Affiliations

Department of Digestive Disease, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Digestive Disease, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Digestive Disease, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Digestive Disease, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Clinical Laboratory, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Digestive Disease, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Digestive Disease, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29502368

Citation

Zhang, J, et al. "[Relationships Between the Enrichment of ETBF, Fn, Hp in Intestinal and Colorectal Cancer]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], vol. 40, no. 2, 2018, pp. 99-104.
Zhang J, Lu XL, Zhao G, et al. [Relationships between the enrichment of ETBF, Fn, Hp in intestinal and colorectal cancer]. Zhonghua Zhong Liu Za Zhi. 2018;40(2):99-104.
Zhang, J., Lu, X. L., Zhao, G., Shi, H. T., Geng, Y., Zhong, W. T., & Dong, L. (2018). [Relationships between the enrichment of ETBF, Fn, Hp in intestinal and colorectal cancer]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 40(2), 99-104. https://doi.org/10.3760/cma.j.issn.0253-3766.2018.02.004
Zhang J, et al. [Relationships Between the Enrichment of ETBF, Fn, Hp in Intestinal and Colorectal Cancer]. Zhonghua Zhong Liu Za Zhi. 2018 Feb 23;40(2):99-104. PubMed PMID: 29502368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationships between the enrichment of ETBF, Fn, Hp in intestinal and colorectal cancer]. AU - Zhang,J, AU - Lu,X L, AU - Zhao,G, AU - Shi,H T, AU - Geng,Y, AU - Zhong,W T, AU - Dong,L, PY - 2018/3/6/entrez PY - 2018/3/6/pubmed PY - 2018/3/14/medline KW - Adenoma KW - Bacteroides fragilis KW - Colonic polyps KW - Colorectal neoplasms KW - Fusobacterium nucleatum KW - Helicobacter pylori SP - 99 EP - 104 JF - Zhonghua zhong liu za zhi [Chinese journal of oncology] JO - Zhonghua Zhong Liu Za Zhi VL - 40 IS - 2 N2 - Objective: To explore relationships between the enrichment of ETBF, Fn, Hp in feces, tissues and colorectal cancer. Methods: Feces, lesion tissue and adjacent tissue from 24 patients with colorectal cancer and 31 patients with adenomas were collected, and we collected Feces and tissue of 20 healthy control persons. Then the copy numbers of enterotoxigenic B. fragilis (ETBF), Fusobacterium nucleatum (Fn) and Helicobacter pylori (Hp) were determined by quantitative real-time PCR. Immunohistochemical method was used to examine the expression intensity of EGFR and p53, and the relationships between different expression intensity of EGFR, p53 and the numbers of three bacterias. Results: In the feces, copy numbers of ETBF and Fn were as follous: colorectal cancer group>adenomas group>healthy control group (P<0.05). Copy numbers of Hp were as follous: colorectal cancer group>healthy control group (P<0.01); adenomas group>healthy control group (P<0.01). In the tissue, copy numbers of ETBF, Fn were as follows: colorectal cancer group>adenomas group>healthy control group (P<0.05). Copy numbers of Hp were as follows: colorectal cancer group>healthy control group (P<0.01); adenomas group>healthy control group (P<0.01). Copy numbers of those three bacteria in the lesion tissue and the adjacent tissue had no significant difference. This happened both in colorectal cancer group and adenomas group. The different expression intensity of EGFR, p53 and the number of three bacteria showed no obviously statistical correlation(P>0.05). Conclusion: Adenomatous polyp and colorectal cancer patients show high enrichment of ETBF, Fn and Hp in both feces and tissues. ETBF, Fn and Hp probably contribute to the development of adenomatous polyp and colorectal cancer. Trial registration Chinese Clinical Trial Registry, ChiCTR-BOC-17012509. SN - 0253-3766 UR - https://www.unboundmedicine.com/medline/citation/29502368/[Relationships_between_the_enrichment_of_ETBF_Fn_Hp_in_intestinal_and_colorectal_cancer]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-3766&amp;year=2018&amp;vol=40&amp;issue=2&amp;fpage=99 DB - PRIME DP - Unbound Medicine ER -