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A new flavone glucoside together with known ellagitannins and flavones with anti-diabetic and anti-obesity activities from the flowers of pomegranate (Punica granatum).
Nat Prod Res. 2019 Jan; 33(2):252-257.NP

Abstract

A new flavone glucoside tricetin 4'-O-β-glucopyranoside (1) and four known ellagitannins and flavones tricetin (2), luteolin (3), ellagic acid (4), and granatin B (5) were isolated from the flowers of Punica granatum L. (Lythraceae). Their structures were established by 1D and 2D NMR as well as mass spectrometry analyses. Among all tested compounds, tricetin (2) exhibited the strongest α-glucosidase inhibitory activity that was comparable to the anti-diabetic drug acarbose. Comparative structure-function analysis of tri-, tetra-, and pentahydroxy flavones [apigenin, luteolin (3), and tricetin (2), respectively] suggested that a greater number of hydroxyl groups on the flavone molecule enhanced its suppression of α-glucosidase, α-amylase, and lipase activities.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wu S
a Shanghai Key Laboratory of Plant Functional Genomics and Resources , Shanghai Chenshan Botanical Garden , Shanghai , China. b Shanghai Chenshan Plant Science Research Centre , Chinese Academy of Sciences , Shanghai , China.
Tian L
a Shanghai Key Laboratory of Plant Functional Genomics and Resources , Shanghai Chenshan Botanical Garden , Shanghai , China. b Shanghai Chenshan Plant Science Research Centre , Chinese Academy of Sciences , Shanghai , China. c Department of Plant Sciences , University of California , Davis , CA , USA.

MeSH

Diabetes MellitusFlavonesFlowersGlucosidesHydrolyzable TanninsLipaseLythraceaeObesityPlant ExtractsStructure-Activity Relationshipalpha-Amylasesalpha-Glucosidases

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29502447

Citation

Wu, Sheng, and Li Tian. "A New Flavone Glucoside Together With Known Ellagitannins and Flavones With Anti-diabetic and Anti-obesity Activities From the Flowers of Pomegranate (Punica Granatum)." Natural Product Research, vol. 33, no. 2, 2019, pp. 252-257.
Wu S, Tian L. A new flavone glucoside together with known ellagitannins and flavones with anti-diabetic and anti-obesity activities from the flowers of pomegranate (Punica granatum). Nat Prod Res. 2019;33(2):252-257.
Wu, S., & Tian, L. (2019). A new flavone glucoside together with known ellagitannins and flavones with anti-diabetic and anti-obesity activities from the flowers of pomegranate (Punica granatum). Natural Product Research, 33(2), 252-257. https://doi.org/10.1080/14786419.2018.1446009
Wu S, Tian L. A New Flavone Glucoside Together With Known Ellagitannins and Flavones With Anti-diabetic and Anti-obesity Activities From the Flowers of Pomegranate (Punica Granatum). Nat Prod Res. 2019;33(2):252-257. PubMed PMID: 29502447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new flavone glucoside together with known ellagitannins and flavones with anti-diabetic and anti-obesity activities from the flowers of pomegranate (Punica granatum). AU - Wu,Sheng, AU - Tian,Li, Y1 - 2018/03/03/ PY - 2018/3/6/pubmed PY - 2019/4/13/medline PY - 2018/3/6/entrez KW - KW - anti-diabetic KW - anti-obesity KW - flower KW - lythraceae SP - 252 EP - 257 JF - Natural product research JO - Nat Prod Res VL - 33 IS - 2 N2 - A new flavone glucoside tricetin 4'-O-β-glucopyranoside (1) and four known ellagitannins and flavones tricetin (2), luteolin (3), ellagic acid (4), and granatin B (5) were isolated from the flowers of Punica granatum L. (Lythraceae). Their structures were established by 1D and 2D NMR as well as mass spectrometry analyses. Among all tested compounds, tricetin (2) exhibited the strongest α-glucosidase inhibitory activity that was comparable to the anti-diabetic drug acarbose. Comparative structure-function analysis of tri-, tetra-, and pentahydroxy flavones [apigenin, luteolin (3), and tricetin (2), respectively] suggested that a greater number of hydroxyl groups on the flavone molecule enhanced its suppression of α-glucosidase, α-amylase, and lipase activities. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/29502447/A_new_flavone_glucoside_together_with_known_ellagitannins_and_flavones_with_anti_diabetic_and_anti_obesity_activities_from_the_flowers_of_pomegranate__Punica_granatum__ DB - PRIME DP - Unbound Medicine ER -