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[Benign metastasizing leiomyoma: An unusual cause of aggressive femoral bone tumor].
Rev Med Interne. 2018 Jun; 39(6):431-434.RM

Abstract

BACKGROUND

Benign metastasizing leiomyoma (BML) is a rare condition characterized by histologically benign "metastatic" smooth muscle tumors, which can affect women with history of uterine surgery. We report the case of a patient with bone metastases of BML.

CASE REPORT

A 78-year-old woman who had undergone uterine surgery six years before hospital admission, was diagnosed with large pulmonary and pleural metastases that necessitated surgical removal. Pathological examination allowed the diagnosis of BML with positive staining for estrogen and progesterone receptors. Three years later, a BML metastasis in the right femoral diaphysis was unexpectedly discovered and treated by osteosynthesis because of a high risk of fracture. Despite an aromatase-inhibitor treatment, new lungs lesions appeared in the next few months.

CONCLUSION

BML is a potential cause of aggressive, although histologically benign, bone tumor in women with a history of uterine surgery.

Authors+Show Affiliations

Service de médecine interne, hôpital Européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France.Service de radiologie, hôpital Européen-Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20 rue Leblanc, 75015 Paris, France.Service de médecine interne, hôpital Européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France.Service de médecine interne, hôpital Européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France.Service de médecine interne, hôpital Européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France.Service de gynécologie, hôpital Européen-Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 15, rue de l'école de médecine, 75006 Paris, France.Service de médecine interne, hôpital Européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 15, rue de l'école de médecine, 75006 Paris, France.Service de médecine interne, hôpital Européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 15, rue de l'école de médecine, 75006 Paris, France. Electronic address: brigitte.ranque@aphp.fr.

Pub Type(s)

Case Reports
Journal Article

Language

fre

PubMed ID

29502928

Citation

Alexandre, L, et al. "[Benign Metastasizing Leiomyoma: an Unusual Cause of Aggressive Femoral Bone Tumor]." La Revue De Medecine Interne, vol. 39, no. 6, 2018, pp. 431-434.
Alexandre L, Taillieu F, Arlet JB, et al. [Benign metastasizing leiomyoma: An unusual cause of aggressive femoral bone tumor]. Rev Med Interne. 2018;39(6):431-434.
Alexandre, L., Taillieu, F., Arlet, J. B., Passeron, A., Michon, A., Bats, A. S., Pouchot, J., & Ranque, B. (2018). [Benign metastasizing leiomyoma: An unusual cause of aggressive femoral bone tumor]. La Revue De Medecine Interne, 39(6), 431-434. https://doi.org/10.1016/j.revmed.2018.02.009
Alexandre L, et al. [Benign Metastasizing Leiomyoma: an Unusual Cause of Aggressive Femoral Bone Tumor]. Rev Med Interne. 2018;39(6):431-434. PubMed PMID: 29502928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Benign metastasizing leiomyoma: An unusual cause of aggressive femoral bone tumor]. AU - Alexandre,L, AU - Taillieu,F, AU - Arlet,J-B, AU - Passeron,A, AU - Michon,A, AU - Bats,A-S, AU - Pouchot,J, AU - Ranque,B, Y1 - 2018/03/02/ PY - 2017/10/01/received PY - 2018/01/27/revised PY - 2018/02/05/accepted PY - 2018/3/6/pubmed PY - 2018/12/12/medline PY - 2018/3/6/entrez KW - Benign metastasizing leiomyoma KW - Cas-clinique KW - Case report KW - Chirurgie utérine KW - Léiomyome métastatique bénin KW - Uterine surgery SP - 431 EP - 434 JF - La Revue de medecine interne JO - Rev Med Interne VL - 39 IS - 6 N2 - BACKGROUND: Benign metastasizing leiomyoma (BML) is a rare condition characterized by histologically benign "metastatic" smooth muscle tumors, which can affect women with history of uterine surgery. We report the case of a patient with bone metastases of BML. CASE REPORT: A 78-year-old woman who had undergone uterine surgery six years before hospital admission, was diagnosed with large pulmonary and pleural metastases that necessitated surgical removal. Pathological examination allowed the diagnosis of BML with positive staining for estrogen and progesterone receptors. Three years later, a BML metastasis in the right femoral diaphysis was unexpectedly discovered and treated by osteosynthesis because of a high risk of fracture. Despite an aromatase-inhibitor treatment, new lungs lesions appeared in the next few months. CONCLUSION: BML is a potential cause of aggressive, although histologically benign, bone tumor in women with a history of uterine surgery. SN - 1768-3122 UR - https://www.unboundmedicine.com/medline/citation/29502928/[Benign_metastasizing_leiomyoma:_An_unusual_cause_of_aggressive_femoral_bone_tumor]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0248-8663(18)30045-6 DB - PRIME DP - Unbound Medicine ER -