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Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population.
Arch Med Res 2017; 48(7):599-608AM

Abstract

BACKGROUND

The brain-derived neurotrophic factor (BDNF) rs6265 (G196A; Val66Met) single nucleotide polymorphism has been associated with BMI and obesity in distinct populations, both adult and pediatric, with contradictory results involving either Val or Met as the risk variant.

AIM OF THE STUDY

To determine the association between the BDNF Val66Met polymorphism and BMI in Mexican children and adolescents.

METHODS

BDNF Val66Met genotyping by restriction fragment length polymorphism and nutritional status characterized by their BMI-for-age z-scores (BAZ) from pediatric volunteers (n = 498) were analyzed by Fisher's exact test association analysis. Standardized residuals (R) were used to determine which genotype/allele had the major influence on the significant Fisher's exact test statistic. Odds ratios were analyzed to measure the association between genotype and normal weight (≥-2 SD < + 1 SD) and overweight (≥ + 1 SD, including obesity, Ow + Ob) status with 95% confidence intervals to estimate the precision of the effect as well as 95% credible intervals to obtain the most probable estimate.

RESULTS

Comparisons between GG (Val/Val), GA (Val/Met) and AA (Met/Met) genotypes or Met homozygotes vs. Val carriers (combination of GG and GA genotypes) showed significant differences (p = 0.034 and p = 0.037, respectively) between normal weight and the combined overweight and obese pediatric subjects. Our data showed that children/adolescents homozygous for the A allele have increased risk of overweight compared to the Val carriers (Bayes OR = 4.2, 95% CI**[1.09-33.1]).

CONCLUSION

This is the first study showing the significant association between the BDNF rs6265 AA (Met/Met) genotype and overweight/obesity in Mexican pediatric population.

Authors+Show Affiliations

Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México; Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Av. Ciudad Universitaria, Coyoacán, Ciudad de México, México.Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México; Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Av. Ciudad Universitaria, Coyoacán, Ciudad de México, México.Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México; Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Av. Ciudad Universitaria, Coyoacán, Ciudad de México, México.Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.Laboratorio de Genómica Funcional, Instituto Nacional de Medicina Genómica, Ciudad de México, México.Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address: hayrov@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29506764

Citation

Martínez-Ezquerro, José Darío, et al. "Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population." Archives of Medical Research, vol. 48, no. 7, 2017, pp. 599-608.
Martínez-Ezquerro JD, Rendón-Macías ME, Zamora-Mendoza G, et al. Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population. Arch Med Res. 2017;48(7):599-608.
Martínez-Ezquerro, J. D., Rendón-Macías, M. E., Zamora-Mendoza, G., Serrano-Meneses, J., Rosales-Rodríguez, B., Escalante-Bautista, D., ... Rosas-Vargas, H. (2017). Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population. Archives of Medical Research, 48(7), pp. 599-608. doi:10.1016/j.arcmed.2018.02.005.
Martínez-Ezquerro JD, et al. Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population. Arch Med Res. 2017;48(7):599-608. PubMed PMID: 29506764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population. AU - Martínez-Ezquerro,José Darío, AU - Rendón-Macías,Mario Enrique, AU - Zamora-Mendoza,Gerardo, AU - Serrano-Meneses,Jacobo, AU - Rosales-Rodríguez,Beatriz, AU - Escalante-Bautista,Deyanira, AU - Rodríguez-Cruz,Maricela, AU - Sánchez-González,Raúl, AU - Arellano-Pineda,Yessica, AU - López-Alarcón,Mardia, AU - Zampedri,María Cecilia, AU - Rosas-Vargas,Haydeé, Y1 - 2018/03/03/ PY - 2017/11/24/received PY - 2018/02/22/accepted PY - 2018/3/7/pubmed PY - 2019/6/30/medline PY - 2018/3/7/entrez KW - BDNF KW - BMI z-score KW - Body weight KW - Obesity KW - Overweight SP - 599 EP - 608 JF - Archives of medical research JO - Arch. Med. Res. VL - 48 IS - 7 N2 - BACKGROUND: The brain-derived neurotrophic factor (BDNF) rs6265 (G196A; Val66Met) single nucleotide polymorphism has been associated with BMI and obesity in distinct populations, both adult and pediatric, with contradictory results involving either Val or Met as the risk variant. AIM OF THE STUDY: To determine the association between the BDNF Val66Met polymorphism and BMI in Mexican children and adolescents. METHODS: BDNF Val66Met genotyping by restriction fragment length polymorphism and nutritional status characterized by their BMI-for-age z-scores (BAZ) from pediatric volunteers (n = 498) were analyzed by Fisher's exact test association analysis. Standardized residuals (R) were used to determine which genotype/allele had the major influence on the significant Fisher's exact test statistic. Odds ratios were analyzed to measure the association between genotype and normal weight (≥-2 SD < + 1 SD) and overweight (≥ + 1 SD, including obesity, Ow + Ob) status with 95% confidence intervals to estimate the precision of the effect as well as 95% credible intervals to obtain the most probable estimate. RESULTS: Comparisons between GG (Val/Val), GA (Val/Met) and AA (Met/Met) genotypes or Met homozygotes vs. Val carriers (combination of GG and GA genotypes) showed significant differences (p = 0.034 and p = 0.037, respectively) between normal weight and the combined overweight and obese pediatric subjects. Our data showed that children/adolescents homozygous for the A allele have increased risk of overweight compared to the Val carriers (Bayes OR = 4.2, 95% CI**[1.09-33.1]). CONCLUSION: This is the first study showing the significant association between the BDNF rs6265 AA (Met/Met) genotype and overweight/obesity in Mexican pediatric population. SN - 1873-5487 UR - https://www.unboundmedicine.com/medline/citation/29506764/Association_Between_the_Brain_derived_Neurotrophic_Factor_Val66Met_Polymorphism_and_Overweight/Obesity_in_Pediatric_Population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(18)30035-3 DB - PRIME DP - Unbound Medicine ER -