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Cross-sectional association between sugar-sweetened beverage intake and cardiometabolic biomarkers in US women.
Br J Nutr. 2018 03; 119(5):570-580.BJ

Abstract

Few studies have evaluated the relationships between intake of sugar-sweetened beverages (SSB) and intermediate biomarkers of cardiometabolic risk. Associations between artificially sweetened beverages (ASB) and fruit juice with cardiometabolic biomarkers are also unclear. We investigated habitual SSB, ASB and fruit juice intake in relation to biomarkers of hepatic function, lipid metabolism, inflammation and glucose metabolism. We analysed cross-sectional data from 8492 participants in the Nurses' Health Study who were free of diabetes and CVD. Multivariate linear regression was used to assess the associations of SSB, ASB and fruit juice intake with concentrations of fetuin-A, alanine transaminase, γ-glutamyl transferase, TAG, HDL-cholesterol, LDL-cholesterol, total cholesterol, C-reactive protein (CRP), intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1, adiponectin, insulin and HbA1c as well as total cholesterol:HDL-cholesterol ratio. More frequent intake of SSB was significantly associated with higher concentrations of fetuin-A, TAG, CRP, ICAM-1, adiponectin and insulin, a higher total cholesterol:HDL-cholesterol ratio, and a lower concentration of HDL-cholesterol (P trend ranges from <0·0001 to 0·04) after adjusting for demographic, medical, dietary and lifestyle variables. ASB intake was marginally associated with increased concentrations of CRP (P trend=0·04) and adiponectin (P trend=0·01). Fruit juice intake was associated with increased concentrations of TAG and HbA1c and a lower concentration of adiponectin (P trend ranges from <0·0001 to 0·01). In conclusion, habitual intake of SSB was associated with adverse levels of multiple cardiometabolic biomarkers. Associations between ASB and fruit juice with cardiometabolic risk markers warrant further exploration.

Authors+Show Affiliations

1Department of Epidemiology,Johns Hopkins Bloomberg School of Public Health,615 N Wolfe Street, Baltimore, MD 21205,USA.2Department of Nutrition,Harvard T.H. Chan School of Public Health,665 Huntington Avenue, Boston, MA 02115,USA.2Department of Nutrition,Harvard T.H. Chan School of Public Health,665 Huntington Avenue, Boston, MA 02115,USA.2Department of Nutrition,Harvard T.H. Chan School of Public Health,665 Huntington Avenue, Boston, MA 02115,USA.2Department of Nutrition,Harvard T.H. Chan School of Public Health,665 Huntington Avenue, Boston, MA 02115,USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29508692

Citation

Yu, Zhi, et al. "Cross-sectional Association Between Sugar-sweetened Beverage Intake and Cardiometabolic Biomarkers in US Women." The British Journal of Nutrition, vol. 119, no. 5, 2018, pp. 570-580.
Yu Z, Ley SH, Sun Q, et al. Cross-sectional association between sugar-sweetened beverage intake and cardiometabolic biomarkers in US women. Br J Nutr. 2018;119(5):570-580.
Yu, Z., Ley, S. H., Sun, Q., Hu, F. B., & Malik, V. S. (2018). Cross-sectional association between sugar-sweetened beverage intake and cardiometabolic biomarkers in US women. The British Journal of Nutrition, 119(5), 570-580. https://doi.org/10.1017/S0007114517003841
Yu Z, et al. Cross-sectional Association Between Sugar-sweetened Beverage Intake and Cardiometabolic Biomarkers in US Women. Br J Nutr. 2018;119(5):570-580. PubMed PMID: 29508692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross-sectional association between sugar-sweetened beverage intake and cardiometabolic biomarkers in US women. AU - Yu,Zhi, AU - Ley,Sylvia H, AU - Sun,Qi, AU - Hu,Frank B, AU - Malik,Vasanti S, PY - 2018/3/7/entrez PY - 2018/3/7/pubmed PY - 2019/2/12/medline KW - AHEI Alternative Healthy Eating Index KW - ASB artificially sweetened beverages KW - CRP C-reactive protein KW - SSB sugar-sweetened beverages KW - Artificially sweetened beverages KW - Cardiometabolic biomarkers KW - Fruit juices KW - Sugar-sweetened beverages SP - 570 EP - 580 JF - The British journal of nutrition JO - Br J Nutr VL - 119 IS - 5 N2 - Few studies have evaluated the relationships between intake of sugar-sweetened beverages (SSB) and intermediate biomarkers of cardiometabolic risk. Associations between artificially sweetened beverages (ASB) and fruit juice with cardiometabolic biomarkers are also unclear. We investigated habitual SSB, ASB and fruit juice intake in relation to biomarkers of hepatic function, lipid metabolism, inflammation and glucose metabolism. We analysed cross-sectional data from 8492 participants in the Nurses' Health Study who were free of diabetes and CVD. Multivariate linear regression was used to assess the associations of SSB, ASB and fruit juice intake with concentrations of fetuin-A, alanine transaminase, γ-glutamyl transferase, TAG, HDL-cholesterol, LDL-cholesterol, total cholesterol, C-reactive protein (CRP), intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1, adiponectin, insulin and HbA1c as well as total cholesterol:HDL-cholesterol ratio. More frequent intake of SSB was significantly associated with higher concentrations of fetuin-A, TAG, CRP, ICAM-1, adiponectin and insulin, a higher total cholesterol:HDL-cholesterol ratio, and a lower concentration of HDL-cholesterol (P trend ranges from <0·0001 to 0·04) after adjusting for demographic, medical, dietary and lifestyle variables. ASB intake was marginally associated with increased concentrations of CRP (P trend=0·04) and adiponectin (P trend=0·01). Fruit juice intake was associated with increased concentrations of TAG and HbA1c and a lower concentration of adiponectin (P trend ranges from <0·0001 to 0·01). In conclusion, habitual intake of SSB was associated with adverse levels of multiple cardiometabolic biomarkers. Associations between ASB and fruit juice with cardiometabolic risk markers warrant further exploration. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/29508692/Cross_sectional_association_between_sugar_sweetened_beverage_intake_and_cardiometabolic_biomarkers_in_US_women_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517003841/type/journal_article DB - PRIME DP - Unbound Medicine ER -