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Intermittent v. continuous energy restriction: differential effects on postprandial glucose and lipid metabolism following matched weight loss in overweight/obese participants.
Br J Nutr. 2018 03; 119(5):507-516.BJ

Abstract

The intermittent energy restriction (IER) approach to weight loss involves short periods of substantial (>70 %) energy restriction (ER) interspersed with normal eating. Studies to date comparing IER to continuous energy restriction (CER) have predominantly measured fasting indices of cardiometabolic risk. This study aimed to compare the effects of IER and CER on postprandial glucose and lipid metabolism following matched weight loss. In all, twenty-seven (thirteen male) overweight/obese participants (46 (sem 3) years, 30·1 (sem 1·0) kg/m2) who were randomised to either an IER intervention (2638 kJ for 2 d/week with an overall ER of 22 (sem 0·3) %, n 15) or a CER intervention (2510 kJ below requirements with overall ER of 23 (sem 0·8) %) completed the study. Postprandial responses to a test meal (over 360 min) and changes in anthropometry (fat mass, fat-free mass, circumferences) were assessed at baseline and upon attainment of 5 % weight loss, following a 7-d period of weight stabilisation. The study found no statistically significant difference in the time to attain a 5 % weight loss between groups (median 59 d (interquartile range (IQR) 41-80) and 73 d (IQR 48-128), respectively, P=0·246), or in body composition (P≥0·437). For postprandial measures, neither diet significantly altered glycaemia (P=0·266), whereas insulinaemia was reduced comparatively (P=0·903). The reduction in C-peptide tended (P=0·057) to be greater following IER (309 128 (sem23 268) to 247781 (sem20 709) pmol×360 min/l) v. CER (297 204 (sem25 112) to 301 655 (sem32 714) pmol×360 min/l). The relative reduction in TAG responses was greater (P=0·045) following IER (106 (sem30) to 68 (sem 15) mmol×360 min/l) compared with CER (117 (sem 43) to 130 (sem 31) mmol×360 min/l). In conclusion, these preliminary findings highlight underlying differences between IER and CER, including a superiority of IER in reducing postprandial lipaemia, which now warrant targeted mechanistic evaluation within larger study cohorts.

Authors+Show Affiliations

1Nutritional Sciences, Faculty of Health and Medical Sciences,University of Surrey,Guildford GU2 7XH,UK.2Lighterlife UK Ltd,Cavendish House,Parkway,Harlow Business Park,Essex CM19 5QF,UK.1Nutritional Sciences, Faculty of Health and Medical Sciences,University of Surrey,Guildford GU2 7XH,UK.1Nutritional Sciences, Faculty of Health and Medical Sciences,University of Surrey,Guildford GU2 7XH,UK.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29508693

Citation

Antoni, Rona, et al. "Intermittent V. Continuous Energy Restriction: Differential Effects On Postprandial Glucose and Lipid Metabolism Following Matched Weight Loss in Overweight/obese Participants." The British Journal of Nutrition, vol. 119, no. 5, 2018, pp. 507-516.
Antoni R, Johnston KL, Collins AL, et al. Intermittent v. continuous energy restriction: differential effects on postprandial glucose and lipid metabolism following matched weight loss in overweight/obese participants. Br J Nutr. 2018;119(5):507-516.
Antoni, R., Johnston, K. L., Collins, A. L., & Robertson, M. D. (2018). Intermittent v. continuous energy restriction: differential effects on postprandial glucose and lipid metabolism following matched weight loss in overweight/obese participants. The British Journal of Nutrition, 119(5), 507-516. https://doi.org/10.1017/S0007114517003890
Antoni R, et al. Intermittent V. Continuous Energy Restriction: Differential Effects On Postprandial Glucose and Lipid Metabolism Following Matched Weight Loss in Overweight/obese Participants. Br J Nutr. 2018;119(5):507-516. PubMed PMID: 29508693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intermittent v. continuous energy restriction: differential effects on postprandial glucose and lipid metabolism following matched weight loss in overweight/obese participants. AU - Antoni,Rona, AU - Johnston,Kelly L, AU - Collins,Adam L, AU - Robertson,M Denise, PY - 2018/3/7/entrez PY - 2018/3/7/pubmed PY - 2019/2/12/medline KW - 3-OHB 3-hydroxybutyrate KW - CER continuous energy restriction KW - ER energy restriction KW - IER intermittent energy restriction KW - REE resting energy expenditure KW - Glucose KW - Humans KW - Intermittent fasting KW - Lipids KW - TAG SP - 507 EP - 516 JF - The British journal of nutrition JO - Br J Nutr VL - 119 IS - 5 N2 - The intermittent energy restriction (IER) approach to weight loss involves short periods of substantial (>70 %) energy restriction (ER) interspersed with normal eating. Studies to date comparing IER to continuous energy restriction (CER) have predominantly measured fasting indices of cardiometabolic risk. This study aimed to compare the effects of IER and CER on postprandial glucose and lipid metabolism following matched weight loss. In all, twenty-seven (thirteen male) overweight/obese participants (46 (sem 3) years, 30·1 (sem 1·0) kg/m2) who were randomised to either an IER intervention (2638 kJ for 2 d/week with an overall ER of 22 (sem 0·3) %, n 15) or a CER intervention (2510 kJ below requirements with overall ER of 23 (sem 0·8) %) completed the study. Postprandial responses to a test meal (over 360 min) and changes in anthropometry (fat mass, fat-free mass, circumferences) were assessed at baseline and upon attainment of 5 % weight loss, following a 7-d period of weight stabilisation. The study found no statistically significant difference in the time to attain a 5 % weight loss between groups (median 59 d (interquartile range (IQR) 41-80) and 73 d (IQR 48-128), respectively, P=0·246), or in body composition (P≥0·437). For postprandial measures, neither diet significantly altered glycaemia (P=0·266), whereas insulinaemia was reduced comparatively (P=0·903). The reduction in C-peptide tended (P=0·057) to be greater following IER (309 128 (sem23 268) to 247781 (sem20 709) pmol×360 min/l) v. CER (297 204 (sem25 112) to 301 655 (sem32 714) pmol×360 min/l). The relative reduction in TAG responses was greater (P=0·045) following IER (106 (sem30) to 68 (sem 15) mmol×360 min/l) compared with CER (117 (sem 43) to 130 (sem 31) mmol×360 min/l). In conclusion, these preliminary findings highlight underlying differences between IER and CER, including a superiority of IER in reducing postprandial lipaemia, which now warrant targeted mechanistic evaluation within larger study cohorts. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/29508693/Intermittent_v__continuous_energy_restriction:_differential_effects_on_postprandial_glucose_and_lipid_metabolism_following_matched_weight_loss_in_overweight/obese_participants_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517003890/type/journal_article DB - PRIME DP - Unbound Medicine ER -