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Standing to lying heart rate variation. A new simple test in the diagnosis of diabetic autonomic neuropathy.
Diabet Med. 1987 Jan-Feb; 4(1):41-3.DM

Abstract

We have examined the immediate heart-rate response to standing to lying (S-L) in 83 male insulin-dependent diabetic subjects aged 40 +/- 11 years (mean +/-S.D.) who underwent five other cardiovascular autonomic tests. Using a specially devised scoring system, the patients were divided into 3 groups: 54 subjects without autonomic neuropathy; 17 'borderlines'; 12 with autonomic neuropathy. The results were compared with those of 50 sex and age matched controls. We evaluated: S-L1 = ratio between R-R mean before lying and R-R minimum over the first 5 beats after lying; S-L2 = ratio between R-R maximum between the 20th to 25th beat and R-R minimum over the first 5 beats after lying. In controls S-L1 was 1.23 +/- 0.098 (mean +/- S.D.), S-L2 1.56 +/- 0.2. In diabetic subjects without autonomic neuropathy S-L1 was 1.18 +/- 0.096 (p less than 0.01), S-L2 1.50 +/- 0.23. In the autonomic group S-L1 was 1.03 +/- 0.01 (p less than 0.001), S-L2 1.16 +/- 0.086 (p less than 0.001). We propose that the lowest normal and highest abnormal limits of S-L1 are 1.10 and 1.07, respectively, and that normal and highest abnormal limits of S-L2 are 1.23 and 1.41, respectively. We suggest the use of S-L1 as a pure parasympathetic test and S-L2 as a mixed but predominantly sympathetic test in the diagnosis of autonomic neuropathy.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

2951218

Citation

Bellavere, F, et al. "Standing to Lying Heart Rate Variation. a New Simple Test in the Diagnosis of Diabetic Autonomic Neuropathy." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 4, no. 1, 1987, pp. 41-3.
Bellavere F, Cardone C, Ferri M, et al. Standing to lying heart rate variation. A new simple test in the diagnosis of diabetic autonomic neuropathy. Diabet Med. 1987;4(1):41-3.
Bellavere, F., Cardone, C., Ferri, M., Guarini, L., Piccoli, A., & Fedele, D. (1987). Standing to lying heart rate variation. A new simple test in the diagnosis of diabetic autonomic neuropathy. Diabetic Medicine : a Journal of the British Diabetic Association, 4(1), 41-3.
Bellavere F, et al. Standing to Lying Heart Rate Variation. a New Simple Test in the Diagnosis of Diabetic Autonomic Neuropathy. Diabet Med. 1987 Jan-Feb;4(1):41-3. PubMed PMID: 2951218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Standing to lying heart rate variation. A new simple test in the diagnosis of diabetic autonomic neuropathy. AU - Bellavere,F, AU - Cardone,C, AU - Ferri,M, AU - Guarini,L, AU - Piccoli,A, AU - Fedele,D, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 41 EP - 3 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 4 IS - 1 N2 - We have examined the immediate heart-rate response to standing to lying (S-L) in 83 male insulin-dependent diabetic subjects aged 40 +/- 11 years (mean +/-S.D.) who underwent five other cardiovascular autonomic tests. Using a specially devised scoring system, the patients were divided into 3 groups: 54 subjects without autonomic neuropathy; 17 'borderlines'; 12 with autonomic neuropathy. The results were compared with those of 50 sex and age matched controls. We evaluated: S-L1 = ratio between R-R mean before lying and R-R minimum over the first 5 beats after lying; S-L2 = ratio between R-R maximum between the 20th to 25th beat and R-R minimum over the first 5 beats after lying. In controls S-L1 was 1.23 +/- 0.098 (mean +/- S.D.), S-L2 1.56 +/- 0.2. In diabetic subjects without autonomic neuropathy S-L1 was 1.18 +/- 0.096 (p less than 0.01), S-L2 1.50 +/- 0.23. In the autonomic group S-L1 was 1.03 +/- 0.01 (p less than 0.001), S-L2 1.16 +/- 0.086 (p less than 0.001). We propose that the lowest normal and highest abnormal limits of S-L1 are 1.10 and 1.07, respectively, and that normal and highest abnormal limits of S-L2 are 1.23 and 1.41, respectively. We suggest the use of S-L1 as a pure parasympathetic test and S-L2 as a mixed but predominantly sympathetic test in the diagnosis of autonomic neuropathy. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/2951218/Standing_to_lying_heart_rate_variation__A_new_simple_test_in_the_diagnosis_of_diabetic_autonomic_neuropathy_ DB - PRIME DP - Unbound Medicine ER -