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Biogenesis of silver nanoparticles using leaf extract of Indigofera hirsuta L. and their potential biomedical applications (3-in-1 system).
Artif Cells Nanomed Biotechnol. 2018; 46(sup1):1138-1148.AC

Abstract

The present study reports the biosynthesis of silver nanoparticles (IH-AgNPs) using aqueous leaf extract of Indigofera hisruta L. The biosynthesized IH-AgNPs were found to be FCC crystals, 5-10 nm in size, spherical in shape and stable. The biosynthesized IH-AgNPs showed dose-dependant cytotoxicity against prostate cancer (PC3) (IC50 = 68.5 μg/mL), colon cancer (COLO205) (IC50 = 85.2 μg/mL), and mouse melanoma (B16F10) (IC50 = 80.9 μg/mL). IH-AgNPs were found to be nontoxic towards normal CHO (Chinese hamster ovary) cells. The biosynthesized IH-AgNPs showed effective in vitro antioxidant activity against DPPH (IC50 = 63.43 μg/mL) and H2O2 (IC50 = 89.93 μg/mL) radicals. IH-AgNPs exhibited effective antibacterial activity against both Gram+ve and Gram-ve bacteria. MIC values of IH-AgNPs against S. aureus, B. subtilis, P. aeruginosa and E. coli were found to be 7.8 μg/mL, 3.9 μg/mL, 15.6 μg/mL and 15.6 μg/mL respectively. IH-AgNPs also showed inhibitory activity against fungal pathogens including C. albicans, C. nonalbicans and C. tropicalis. Considering the results together, we demonstrate that IH-AgNPs exhibits three different bioactivities (3-in-1 system) and they could be employed as future antimicrobial, antioxidant and anticancer agents/drug delivery vehicles in the field of biomedicine.

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Authors+Show Affiliations

a Department of Biotechnology , Sri Venkateswara University , Tirupati , India.

b Department of Biochemistry , Sri Venkateswara University , Tirupati , India.

a Department of Biotechnology , Sri Venkateswara University , Tirupati , India.

a Department of Biotechnology , Sri Venkateswara University , Tirupati , India.

a Department of Biotechnology , Sri Venkateswara University , Tirupati , India.

c Division of Biology , Indian Institute of Chemical Technology , Hyderabad , India.

d DST-PURSE Centre , Sri Venkateswara University , Tirupati , India.

a Department of Biotechnology , Sri Venkateswara University , Tirupati , India.

e Department of Botany , Sri Venkateswara University , Tirupati , India.

MeSH

AnimalsAnti-Infective AgentsAntineoplastic AgentsAntioxidantsCell Line, TumorHumansIndigoferaMetal NanoparticlesMicePlant LeavesSilver

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29513113

Citation

Netala, Vasudeva Reddy, et al. "Biogenesis of Silver Nanoparticles Using Leaf Extract of Indigofera Hirsuta L. and Their Potential Biomedical Applications (3-in-1 System)." Artificial Cells, Nanomedicine, and Biotechnology, vol. 46, no. sup1, 2018, pp. 1138-1148.

Netala VR, Bukke S, Domdi L, et al. Biogenesis of silver nanoparticles using leaf extract of Indigofera hirsuta L. and their potential biomedical applications (3-in-1 system). Artif Cells Nanomed Biotechnol. 2018;46(sup1):1138-1148.

Netala, V. R., Bukke, S., Domdi, L., Soneya, S., G Reddy, S., Bethu, M. S., Kotakdi, V. S., Saritha, K. V., & Tartte, V. (2018). Biogenesis of silver nanoparticles using leaf extract of Indigofera hirsuta L. and their potential biomedical applications (3-in-1 system). Artificial Cells, Nanomedicine, and Biotechnology, 46(sup1), 1138-1148. https://doi.org/10.1080/21691401.2018.1446967

Netala VR, et al. Biogenesis of Silver Nanoparticles Using Leaf Extract of Indigofera Hirsuta L. and Their Potential Biomedical Applications (3-in-1 System). Artif Cells Nanomed Biotechnol. 2018;46(sup1):1138-1148. PubMed PMID: 29513113.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Biogenesis of silver nanoparticles using leaf extract of Indigofera hirsuta L. and their potential biomedical applications (3-in-1 system). AU - Netala,Vasudeva Reddy, AU - Bukke,Suman, AU - Domdi,Latha, AU - Soneya,S, AU - G Reddy,Sindhu, AU - Bethu,Murali Satyanarayana, AU - Kotakdi,Venkata Subbaiah, AU - Saritha,K V, AU - Tartte,Vijaya, Y1 - 2018/03/07/ PY - 2018/3/8/pubmed PY - 2019/8/21/medline PY - 2018/3/8/entrez KW - COLO205 and PC3 KW - Indigofera hirsuta KW - anticancer activity KW - antimicrobial activity KW - free radical scavenging activity KW - silver nanoparticles SP - 1138 EP - 1148 JF - Artificial cells, nanomedicine, and biotechnology JO - Artif Cells Nanomed Biotechnol VL - 46 IS - sup1 N2 - The present study reports the biosynthesis of silver nanoparticles (IH-AgNPs) using aqueous leaf extract of Indigofera hisruta L. The biosynthesized IH-AgNPs were found to be FCC crystals, 5-10 nm in size, spherical in shape and stable. The biosynthesized IH-AgNPs showed dose-dependant cytotoxicity against prostate cancer (PC3) (IC50 = 68.5 μg/mL), colon cancer (COLO205) (IC50 = 85.2 μg/mL), and mouse melanoma (B16F10) (IC50 = 80.9 μg/mL). IH-AgNPs were found to be nontoxic towards normal CHO (Chinese hamster ovary) cells. The biosynthesized IH-AgNPs showed effective in vitro antioxidant activity against DPPH (IC50 = 63.43 μg/mL) and H2O2 (IC50 = 89.93 μg/mL) radicals. IH-AgNPs exhibited effective antibacterial activity against both Gram+ve and Gram-ve bacteria. MIC values of IH-AgNPs against S. aureus, B. subtilis, P. aeruginosa and E. coli were found to be 7.8 μg/mL, 3.9 μg/mL, 15.6 μg/mL and 15.6 μg/mL respectively. IH-AgNPs also showed inhibitory activity against fungal pathogens including C. albicans, C. nonalbicans and C. tropicalis. Considering the results together, we demonstrate that IH-AgNPs exhibits three different bioactivities (3-in-1 system) and they could be employed as future antimicrobial, antioxidant and anticancer agents/drug delivery vehicles in the field of biomedicine. SN - 2169-141X UR - https://www.unboundmedicine.com/medline/citation/29513113/Biogenesis_of_silver_nanoparticles_using_leaf_extract_of_Indigofera_hirsuta_L._and_their_potential_biomedical_applications_(3-in-1_system). DB - PRIME DP - Unbound Medicine ER -