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Pretreatment Histoplasma capsulatum urine enzymatic immunoassay concentrations do not correlate with outcome but may be influenced by renal function in cats with histoplasmosis.
J Feline Med Surg. 2018 12; 20(12):1177-1179.JF

Abstract

OBJECTIVES

The objective of this study was to determine if urine Histoplasma antigen (HAg) enzyme immunoassay (EIA) concentrations at the time of diagnosis and prior to the administration of antifungal agents are predictive of outcome for cats infected with Histoplasma capsulatum and to determine if compromised renal function affects urine HAg EIA measurements.

METHODS

Medical records at four institutions were searched to identify cats diagnosed with histoplasmosis between April 2012 and December 2015. Pretreatment urine Histoplasma EIA values were recorded, along with patient signalment, serum creatinine concentration, urine specific gravity, site(s) of infection and survival data.

RESULTS

Pretreatment urine HAg EIA measurements were available for 50 cats, and ranged from 0-19.1 ng/ml (median 6.3 ng/ml). Thirty-five cats were alive at day 180, 12 had died or were euthanized (median survival time 24 days; range 2-124 days) and three were lost to follow-up. The median urine HAg EIA at the time of diagnosis for cats alive at 6 months was 5 ng/ml (range 0-19.1); this was similar to findings for the non-survivors (median 7.29 ng/ml; range 0.78-19.1; P = 0.54). Surviving cats were significantly younger (mean age 6.9 years) than non-survivors (mean age 9.9 years; P = 0.03) but median body weights (3.8 kg vs 3.6 kg) and rates of pulmonary involvement (22/35 vs 9/12) were similar for the two groups. Median urine HAg EIA concentration was lower in cats with evidence of renal compromise than cats with acceptable renal function (0.54 ng/ml vs 7.2 ng/ml; P <0.013).

CONCLUSIONS AND RELEVANCE

Urine HAg EIA concentrations at the time of diagnosis are not predictive of outcome in cats with histoplasmosis and should not be used as a prognostic indicator in this species. Renal function may influence urine HAg EIA concentrations in cats; further investigation is needed to see if concurrent kidney disease impacts test sensitivity.

Authors+Show Affiliations

1 Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, LA, USA.2 Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA.3 Department of Clinical Sciences, Kansas State University, Manhattan, KS, USA.4 Alamo Feline Health Center, San Antonio, TX, USA.5 Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29513156

Citation

McGill, Jennifer E., et al. "Pretreatment Histoplasma Capsulatum Urine Enzymatic Immunoassay Concentrations Do Not Correlate With Outcome but May Be Influenced By Renal Function in Cats With Histoplasmosis." Journal of Feline Medicine and Surgery, vol. 20, no. 12, 2018, pp. 1177-1179.
McGill JE, Hanzlicek AS, Kukanich KS, et al. Pretreatment Histoplasma capsulatum urine enzymatic immunoassay concentrations do not correlate with outcome but may be influenced by renal function in cats with histoplasmosis. J Feline Med Surg. 2018;20(12):1177-1179.
McGill, J. E., Hanzlicek, A. S., Kukanich, K. S., Norsworthy, G. D., & Cook, A. K. (2018). Pretreatment Histoplasma capsulatum urine enzymatic immunoassay concentrations do not correlate with outcome but may be influenced by renal function in cats with histoplasmosis. Journal of Feline Medicine and Surgery, 20(12), 1177-1179. https://doi.org/10.1177/1098612X18761440
McGill JE, et al. Pretreatment Histoplasma Capsulatum Urine Enzymatic Immunoassay Concentrations Do Not Correlate With Outcome but May Be Influenced By Renal Function in Cats With Histoplasmosis. J Feline Med Surg. 2018;20(12):1177-1179. PubMed PMID: 29513156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pretreatment Histoplasma capsulatum urine enzymatic immunoassay concentrations do not correlate with outcome but may be influenced by renal function in cats with histoplasmosis. AU - McGill,Jennifer E, AU - Hanzlicek,Andrew S, AU - Kukanich,Kate S, AU - Norsworthy,Gary D, AU - Cook,Audrey K, Y1 - 2018/03/07/ PY - 2018/3/8/pubmed PY - 2019/9/13/medline PY - 2018/3/8/entrez SP - 1177 EP - 1179 JF - Journal of feline medicine and surgery JO - J Feline Med Surg VL - 20 IS - 12 N2 - OBJECTIVES: The objective of this study was to determine if urine Histoplasma antigen (HAg) enzyme immunoassay (EIA) concentrations at the time of diagnosis and prior to the administration of antifungal agents are predictive of outcome for cats infected with Histoplasma capsulatum and to determine if compromised renal function affects urine HAg EIA measurements. METHODS: Medical records at four institutions were searched to identify cats diagnosed with histoplasmosis between April 2012 and December 2015. Pretreatment urine Histoplasma EIA values were recorded, along with patient signalment, serum creatinine concentration, urine specific gravity, site(s) of infection and survival data. RESULTS: Pretreatment urine HAg EIA measurements were available for 50 cats, and ranged from 0-19.1 ng/ml (median 6.3 ng/ml). Thirty-five cats were alive at day 180, 12 had died or were euthanized (median survival time 24 days; range 2-124 days) and three were lost to follow-up. The median urine HAg EIA at the time of diagnosis for cats alive at 6 months was 5 ng/ml (range 0-19.1); this was similar to findings for the non-survivors (median 7.29 ng/ml; range 0.78-19.1; P = 0.54). Surviving cats were significantly younger (mean age 6.9 years) than non-survivors (mean age 9.9 years; P = 0.03) but median body weights (3.8 kg vs 3.6 kg) and rates of pulmonary involvement (22/35 vs 9/12) were similar for the two groups. Median urine HAg EIA concentration was lower in cats with evidence of renal compromise than cats with acceptable renal function (0.54 ng/ml vs 7.2 ng/ml; P <0.013). CONCLUSIONS AND RELEVANCE: Urine HAg EIA concentrations at the time of diagnosis are not predictive of outcome in cats with histoplasmosis and should not be used as a prognostic indicator in this species. Renal function may influence urine HAg EIA concentrations in cats; further investigation is needed to see if concurrent kidney disease impacts test sensitivity. SN - 1532-2750 UR - https://www.unboundmedicine.com/medline/citation/29513156/Pretreatment_Histoplasma_capsulatum_urine_enzymatic_immunoassay_concentrations_do_not_correlate_with_outcome_but_may_be_influenced_by_renal_function_in_cats_with_histoplasmosis_ L2 - https://journals.sagepub.com/doi/10.1177/1098612X18761440?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -