TY - JOUR T1 - Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models. AU - Safwan Ali Khan,Mohammed, AU - Khatoon,Nishath, AU - Al-Sanea,Mohammad M, AU - Gamal Mahmoud,Mohamed, AU - Rahman,Hidayat Ur, Y1 - 2018/03/07/ PY - 2017/10/12/received PY - 2018/03/07/accepted PY - 2018/3/8/pubmed PY - 2018/11/27/medline PY - 2018/3/8/entrez KW - Anti-inflammatory activity KW - Carrageenan KW - Granuloma KW - Terminalia coriacea SP - 267 EP - 271 JF - Medical principles and practice : international journal of the Kuwait University, Health Science Centre JO - Med Princ Pract VL - 27 IS - 3 N2 - OBJECTIVE: The aim of the present study was to evaluate anti-inflammatory activity of methanolic extract of Terminalia coriacea. MATERIALS AND METHODS: A methanolic extract of T. coriacea leaves was studied in albino Wistar rats with carrageenan-induced paw edema, an acute model, and cotton pellet-induced granuloma, a chronic model, at 3 oral test doses (125, 250, and 500 mg/kg). Aspirin 100 mg/kg was used as a positive control. Paw volume and wet and dry weights of cotton pellets were determined. The data were analyzed by one-way ANOVA followed by Dunnett's multiple comparison test. RESULTS: The test extract at doses of 125 and 250 mg/kg decreased paw volume and wet and dry weights of cotton pellets. The highest test dose (500 mg/kg) displayed a response comparable to that of the standard drug (p < 0.01) on paw volume. The extract produced similar (p < 0.05) decrease in wet weight of the cotton pellet at 125 and 250 mg/kg, whereas the effect of 500 mg/kg of the extract was comparable to that of aspirin 100 mg/kg (p < 0.01). The extract of T. coriacea at 500 mg/kg induced the most significant (p < 0.01) effect on wet weight of granulomatous tissue. CONCLUSION: The methanolic extract of T. coriacea leaves successfully decreased paw edema as well as dry and wet weights of granulomatous tissue in both acute and chronic inflammatory models thus confirming the anti- edematogenic, antitransudative, and antiproliferative properties of T. coriacea. SN - 1423-0151 UR - https://www.unboundmedicine.com/medline/citation/29514164/Methanolic_Extract_of_Leathery_Murdah_Terminalia_coriacea__Roxb___Wight_and_Arn__Leaves_Exhibits_Anti_Inflammatory_Activity_in_Acute_and_Chronic_Models_ L2 - https://www.karger.com?DOI=10.1159/000488199 DB - PRIME DP - Unbound Medicine ER -