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The relationship between nut intake and risk of colorectal cancer: a case control study.
Nutr J. 2018 03 07; 17(1):37.NJ

Abstract

BACKGROUND

Nut consumption is known to reduce the risk of obesity, diabetes mellitus, and cardiovascular disease. However, in previous studies, portion sizes and categories of nut consumption have varied, and few studies have assessed the association between colorectal cancer risk and nut consumption. In this study, we investigated the relationship between nut consumption and colorectal cancer risk.

METHODS

A case-control study was conducted among 923 colorectal cancer patients and 1846 controls recruited from the National Cancer Center in Korea. Information on dietary intake was collected using a semi-quantitative food frequency questionnaire with 106 items, including peanuts, pine nuts, and almonds (as 1 food item). Nut consumption was categorized as none, < 1 serving per week, 1-3 servings per week, and ≥3 servings per week. A binary logistic regression model was used to estimate odds ratios (OR) and their 95% confidence intervals (CI) for the association between nut consumption and colorectal cancer risk, and a polytomous logistic regression model was used for sub-site analyses.

RESULTS

High nut consumption was strongly associated with reduced risk of colorectal cancer among women (adjusted ORs: 0.30, 95%CI: 0.15-0.60 for the ≥3 servings per week group vs. none). A similar inverse association was observed for men (adjusted ORs: 0.28, 95% CI: 0.17-0.47). In sub-site analyses, adjusted ORs (95% CIs) comparing the ≥3 servings per week group vs none were 0.25 (0.09-0.70) for proximal colon cancer, 0.39 (0.19-0.80) for distal colon cancer, and 0.23 (0.12-0.46) for rectal cancer among men. An inverse association was also found among women for distal colon cancer (OR: 0.13, 95% CI: 0.04-0.48) and rectal cancer (OR: 0.40, 95% CI: 0.17-0.95).

CONCLUSIONS

We found a statistically significant association between high frequency of nut consumption and reduced risk of colorectal cancer. This association was observed for all sub-sites of the colon and rectum among both men and women, with the exception of proximal colon cancer for women.

Authors+Show Affiliations

Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehakro, Jongno-gu, Seoul, 03080, South Korea.Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehakro, Jongno-gu, Seoul, 03080, South Korea. shinaesun@snu.ac.kr. Cancer Research Institute, Seoul National University, 103 Daehakro, Jongno-gu, Seoul, 03080, South Korea. shinaesun@snu.ac.kr.Center for Colorectal Cancer, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, 10408, Gyeonggi-do, South Korea.Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, 10408, Gyeonggi-do, South Korea. jskim@ncc.re.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29514652

Citation

Lee, Jeeyoo, et al. "The Relationship Between Nut Intake and Risk of Colorectal Cancer: a Case Control Study." Nutrition Journal, vol. 17, no. 1, 2018, p. 37.
Lee J, Shin A, Oh JH, et al. The relationship between nut intake and risk of colorectal cancer: a case control study. Nutr J. 2018;17(1):37.
Lee, J., Shin, A., Oh, J. H., & Kim, J. (2018). The relationship between nut intake and risk of colorectal cancer: a case control study. Nutrition Journal, 17(1), 37. https://doi.org/10.1186/s12937-018-0345-y
Lee J, et al. The Relationship Between Nut Intake and Risk of Colorectal Cancer: a Case Control Study. Nutr J. 2018 03 7;17(1):37. PubMed PMID: 29514652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between nut intake and risk of colorectal cancer: a case control study. AU - Lee,Jeeyoo, AU - Shin,Aesun, AU - Oh,Jae Hwan, AU - Kim,Jeongseon, Y1 - 2018/03/07/ PY - 2017/11/22/received PY - 2018/03/01/accepted PY - 2018/3/9/entrez PY - 2018/3/9/pubmed PY - 2019/6/6/medline KW - Case-control study KW - Colorectal cancer KW - Korea KW - Nut SP - 37 EP - 37 JF - Nutrition journal JO - Nutr J VL - 17 IS - 1 N2 - BACKGROUND: Nut consumption is known to reduce the risk of obesity, diabetes mellitus, and cardiovascular disease. However, in previous studies, portion sizes and categories of nut consumption have varied, and few studies have assessed the association between colorectal cancer risk and nut consumption. In this study, we investigated the relationship between nut consumption and colorectal cancer risk. METHODS: A case-control study was conducted among 923 colorectal cancer patients and 1846 controls recruited from the National Cancer Center in Korea. Information on dietary intake was collected using a semi-quantitative food frequency questionnaire with 106 items, including peanuts, pine nuts, and almonds (as 1 food item). Nut consumption was categorized as none, < 1 serving per week, 1-3 servings per week, and ≥3 servings per week. A binary logistic regression model was used to estimate odds ratios (OR) and their 95% confidence intervals (CI) for the association between nut consumption and colorectal cancer risk, and a polytomous logistic regression model was used for sub-site analyses. RESULTS: High nut consumption was strongly associated with reduced risk of colorectal cancer among women (adjusted ORs: 0.30, 95%CI: 0.15-0.60 for the ≥3 servings per week group vs. none). A similar inverse association was observed for men (adjusted ORs: 0.28, 95% CI: 0.17-0.47). In sub-site analyses, adjusted ORs (95% CIs) comparing the ≥3 servings per week group vs none were 0.25 (0.09-0.70) for proximal colon cancer, 0.39 (0.19-0.80) for distal colon cancer, and 0.23 (0.12-0.46) for rectal cancer among men. An inverse association was also found among women for distal colon cancer (OR: 0.13, 95% CI: 0.04-0.48) and rectal cancer (OR: 0.40, 95% CI: 0.17-0.95). CONCLUSIONS: We found a statistically significant association between high frequency of nut consumption and reduced risk of colorectal cancer. This association was observed for all sub-sites of the colon and rectum among both men and women, with the exception of proximal colon cancer for women. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/29514652/The_relationship_between_nut_intake_and_risk_of_colorectal_cancer:_a_case_control_study_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-018-0345-y DB - PRIME DP - Unbound Medicine ER -