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[The 8-year follow-up study for clinical diagnostic potentials of frequency-doubling technology perimetry for perimetrically normal eyes of open-angle glaucoma patients with unilateral visual field loss].
Zhonghua Yan Ke Za Zhi. 2018 Mar 11; 54(3):177-183.ZY

Abstract

Objective:

To analyze potentials of frequency-doubling technology perimetry (FDP) for diagnosing open-angle glaucoma (OAG) in perimetrically normal eyes of OAG patients diagnosed with standard automated perimetry (SAP) and relating factors from abnormalities on FDP to visual field loss on SAP.

Methods:

A prospective cohort study. Sixty-eight eyes of 68 OAG patients visiting the ophthalmic clinic of Peking University Third Hospital during November 2003 and October 2007 [32 primary open-angle glaucoma patients and 36 normal tension glaucoma patients, 32 males and 36 females, with an average age of (59±13) years] with unilateral field loss detected by SAP (Octopus101 tG2 program) were examined with the FDP N-30 threshold program (Humphrey Instruments) at baseline. Two groups, FDP positive group and FDP negative group, were divided based on the FDP results, and visual field examinations were followed by a series of SAP examinations for the perimetrically normal eyes over 8 years. During the follow-up, the difference of the converting rate of SAP tests between the two groups was analyzed. Differences between "convertors" and "non-convertors" of SAP tests in the FDP positive group, such as the cup-to-disk ratio and glaucomatous optic neuropathy rate, were also compared with the independent-sample t test or Wilcoxon two-sample test for continuous variable data and the χ(2) test or Fisher exact test for classified variable data and rates.

Results:

Forty-eight perimetrically normal eyes of 48 participants had complete data and a qualifying follow-up. Baseline FDP results were positive in 33 eyes and negative in 15 eyes. Of the eyes with positive FDP results, 22 eyes developed abnormal SAP results after 4.0 to 90.0 months (median 14.5 months) , whereas none of the eyes with negative FDP results developed abnormal SAP results. For perimetrically normal eyes in the FDP positive group, "converters" showed a greater cup-to-disk ratio (0.73±0.09 vs. 0.63±0.14, Wilcoxon two-sample test, P=0.011) and more eyes with glaucomatous optic neuropathy (19/22 vs. 4/11, Fisher exact test, P=0.006).

Conclusions:

In perimetrically normal eyes of OAG patients, FDP could detect visual field loss of these eyes and predict to some extent future visual field loss on SAP. Severity of glaucomatous optic neuropathy at baseline is related to converting from abnormalities on FDP to visual field loss on SAP. (Chin J Ophthalmol, 2018, 54: 177-183).

Authors+Show Affiliations

Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Beijing 100191, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29518875

Citation

Fan, X, et al. "[The 8-year Follow-up Study for Clinical Diagnostic Potentials of Frequency-doubling Technology Perimetry for Perimetrically Normal Eyes of Open-angle Glaucoma Patients With Unilateral Visual Field Loss]." [Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology, vol. 54, no. 3, 2018, pp. 177-183.
Fan X, Wu LL, Xiao GG, et al. [The 8-year follow-up study for clinical diagnostic potentials of frequency-doubling technology perimetry for perimetrically normal eyes of open-angle glaucoma patients with unilateral visual field loss]. Zhonghua Yan Ke Za Zhi. 2018;54(3):177-183.
Fan, X., Wu, L. L., Xiao, G. G., Ma, Z. Z., & Liu, F. (2018). [The 8-year follow-up study for clinical diagnostic potentials of frequency-doubling technology perimetry for perimetrically normal eyes of open-angle glaucoma patients with unilateral visual field loss]. [Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology, 54(3), 177-183. https://doi.org/10.3760/cma.j.issn.0412-4081.2018.03.006
Fan X, et al. [The 8-year Follow-up Study for Clinical Diagnostic Potentials of Frequency-doubling Technology Perimetry for Perimetrically Normal Eyes of Open-angle Glaucoma Patients With Unilateral Visual Field Loss]. Zhonghua Yan Ke Za Zhi. 2018 Mar 11;54(3):177-183. PubMed PMID: 29518875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The 8-year follow-up study for clinical diagnostic potentials of frequency-doubling technology perimetry for perimetrically normal eyes of open-angle glaucoma patients with unilateral visual field loss]. AU - Fan,X, AU - Wu,L L, AU - Xiao,G G, AU - Ma,Z Z, AU - Liu,F, PY - 2018/3/10/entrez PY - 2018/3/10/pubmed PY - 2019/6/22/medline KW - Follow-up studies KW - Glaucoma, open-angle KW - Optic nerve diseases KW - Vision, monocula KW - Visual field tests SP - 177 EP - 183 JF - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology JO - Zhonghua Yan Ke Za Zhi VL - 54 IS - 3 N2 - Objective: To analyze potentials of frequency-doubling technology perimetry (FDP) for diagnosing open-angle glaucoma (OAG) in perimetrically normal eyes of OAG patients diagnosed with standard automated perimetry (SAP) and relating factors from abnormalities on FDP to visual field loss on SAP. Methods: A prospective cohort study. Sixty-eight eyes of 68 OAG patients visiting the ophthalmic clinic of Peking University Third Hospital during November 2003 and October 2007 [32 primary open-angle glaucoma patients and 36 normal tension glaucoma patients, 32 males and 36 females, with an average age of (59±13) years] with unilateral field loss detected by SAP (Octopus101 tG2 program) were examined with the FDP N-30 threshold program (Humphrey Instruments) at baseline. Two groups, FDP positive group and FDP negative group, were divided based on the FDP results, and visual field examinations were followed by a series of SAP examinations for the perimetrically normal eyes over 8 years. During the follow-up, the difference of the converting rate of SAP tests between the two groups was analyzed. Differences between "convertors" and "non-convertors" of SAP tests in the FDP positive group, such as the cup-to-disk ratio and glaucomatous optic neuropathy rate, were also compared with the independent-sample t test or Wilcoxon two-sample test for continuous variable data and the χ(2) test or Fisher exact test for classified variable data and rates. Results: Forty-eight perimetrically normal eyes of 48 participants had complete data and a qualifying follow-up. Baseline FDP results were positive in 33 eyes and negative in 15 eyes. Of the eyes with positive FDP results, 22 eyes developed abnormal SAP results after 4.0 to 90.0 months (median 14.5 months) , whereas none of the eyes with negative FDP results developed abnormal SAP results. For perimetrically normal eyes in the FDP positive group, "converters" showed a greater cup-to-disk ratio (0.73±0.09 vs. 0.63±0.14, Wilcoxon two-sample test, P=0.011) and more eyes with glaucomatous optic neuropathy (19/22 vs. 4/11, Fisher exact test, P=0.006). Conclusions: In perimetrically normal eyes of OAG patients, FDP could detect visual field loss of these eyes and predict to some extent future visual field loss on SAP. Severity of glaucomatous optic neuropathy at baseline is related to converting from abnormalities on FDP to visual field loss on SAP. (Chin J Ophthalmol, 2018, 54: 177-183). SN - 0412-4081 UR - https://www.unboundmedicine.com/medline/citation/29518875/[The_8_year_follow_up_study_for_clinical_diagnostic_potentials_of_frequency_doubling_technology_perimetry_for_perimetrically_normal_eyes_of_open_angle_glaucoma_patients_with_unilateral_visual_field_loss]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0412-4081&year=2018&vol=54&issue=3&fpage=177 DB - PRIME DP - Unbound Medicine ER -