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Biodegradable and electroconductive poly(3,4-ethylenedioxythiophene)/carboxymethyl chitosan hydrogels for neural tissue engineering.
Mater Sci Eng C Mater Biol Appl. 2018 Mar 01; 84:32-43.MS

Abstract

Electroconductive hydrogels with excellent electromechanical properties have become crucial for biomedical applications. In this study, we developed a conductive composite hydrogel via in-situ chemical polymerization based on carboxymethyl chitosan (CMCS), as a biodegradable base macromolecular network, and poly(3,4-ethylenedioxythiophene) (PEDOT), as a conductive polymer layer. The physicochemical and electrochemical properties of conductive hydrogels (PEDOT/CMCS) with different contents of PEDOT polymer were analyzed. Cell viability and proliferation of neuron-like rat phaeochromocytoma (PC12) cells on these three-dimensional conductive hydrogels were evaluated in vitro. As results, the prepared semi-interpenetrating network hydrogels were shown to consist of up to 1825±135wt% of water with a compressive modulus of 9.59±0.49kPa, a porosity of 93.95±1.03% and an electrical conductivity of (4.68±0.28)×10-3S·cm-1. Cell experiments confirmed that PEDOT/CMCS hydrogels not only had no cytotoxicity, but also supported cell adhesion, viability and proliferation. These results demonstrated that the incorporation of conductive PEDOT component into CMCS hydrogels endowed the hydrogels with enhanced mechanical strength, conductivity and kept the biocompatibility. Thus, the attractive performances of these composite hydrogels would make them suitable for further neural tissue engineering application, such as nerve regeneration scaffold materials.

Authors+Show Affiliations

Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, PR China.Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, PR China. Electronic address: guanshui@dlut.edu.cn.Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, PR China.State Key Laboratory of Fine Chemicals and School of Chemical Engineering, Dalian University of Technology, Dalian 116024, PR China.Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, PR China.Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, PR China.Department of Biomedical Engineering, Dalian University of Technology, Dalian 116024, PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29519441

Citation

Xu, Chao, et al. "Biodegradable and Electroconductive Poly(3,4-ethylenedioxythiophene)/carboxymethyl Chitosan Hydrogels for Neural Tissue Engineering." Materials Science & Engineering. C, Materials for Biological Applications, vol. 84, 2018, pp. 32-43.
Xu C, Guan S, Wang S, et al. Biodegradable and electroconductive poly(3,4-ethylenedioxythiophene)/carboxymethyl chitosan hydrogels for neural tissue engineering. Mater Sci Eng C Mater Biol Appl. 2018;84:32-43.
Xu, C., Guan, S., Wang, S., Gong, W., Liu, T., Ma, X., & Sun, C. (2018). Biodegradable and electroconductive poly(3,4-ethylenedioxythiophene)/carboxymethyl chitosan hydrogels for neural tissue engineering. Materials Science & Engineering. C, Materials for Biological Applications, 84, 32-43. https://doi.org/10.1016/j.msec.2017.11.032
Xu C, et al. Biodegradable and Electroconductive Poly(3,4-ethylenedioxythiophene)/carboxymethyl Chitosan Hydrogels for Neural Tissue Engineering. Mater Sci Eng C Mater Biol Appl. 2018 Mar 1;84:32-43. PubMed PMID: 29519441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biodegradable and electroconductive poly(3,4-ethylenedioxythiophene)/carboxymethyl chitosan hydrogels for neural tissue engineering. AU - Xu,Chao, AU - Guan,Shui, AU - Wang,Shuping, AU - Gong,Weitao, AU - Liu,Tianqing, AU - Ma,Xuehu, AU - Sun,Changkai, Y1 - 2017/11/24/ PY - 2017/07/31/received PY - 2017/09/27/revised PY - 2017/11/22/accepted PY - 2018/3/10/entrez PY - 2018/3/10/pubmed PY - 2018/9/1/medline KW - Biodegradable KW - Carboxymethyl chitosan KW - Conductive hydrogel KW - Neural tissue engineering KW - Poly(3,4-ethylenedioxythiophene) SP - 32 EP - 43 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 84 N2 - Electroconductive hydrogels with excellent electromechanical properties have become crucial for biomedical applications. In this study, we developed a conductive composite hydrogel via in-situ chemical polymerization based on carboxymethyl chitosan (CMCS), as a biodegradable base macromolecular network, and poly(3,4-ethylenedioxythiophene) (PEDOT), as a conductive polymer layer. The physicochemical and electrochemical properties of conductive hydrogels (PEDOT/CMCS) with different contents of PEDOT polymer were analyzed. Cell viability and proliferation of neuron-like rat phaeochromocytoma (PC12) cells on these three-dimensional conductive hydrogels were evaluated in vitro. As results, the prepared semi-interpenetrating network hydrogels were shown to consist of up to 1825±135wt% of water with a compressive modulus of 9.59±0.49kPa, a porosity of 93.95±1.03% and an electrical conductivity of (4.68±0.28)×10-3S·cm-1. Cell experiments confirmed that PEDOT/CMCS hydrogels not only had no cytotoxicity, but also supported cell adhesion, viability and proliferation. These results demonstrated that the incorporation of conductive PEDOT component into CMCS hydrogels endowed the hydrogels with enhanced mechanical strength, conductivity and kept the biocompatibility. Thus, the attractive performances of these composite hydrogels would make them suitable for further neural tissue engineering application, such as nerve regeneration scaffold materials. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/29519441/Biodegradable_and_electroconductive_poly_34_ethylenedioxythiophene_/carboxymethyl_chitosan_hydrogels_for_neural_tissue_engineering_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-4931(17)32938-7 DB - PRIME DP - Unbound Medicine ER -